Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of cold tablet containing Artemisia carvifolia and holly root, and application of cold tablet in mastocytoma cell P815 cell proliferation inhibition medicines

A Qingmei Ganmao tablet and extraction technology are applied in the directions of antitumor drugs, drug combinations, and medical preparations containing active ingredients, etc., which can solve the problems of large dosage, rough process, and many impurities for patients, and achieve small dosage and dosage No bitterness, the effect of reducing dosage

Inactive Publication Date: 2014-04-30
JINAN XINQIDIAN MEDICAL TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Qingmei Ganmao Granules. However, the method of extracting volatile oil and decocting in water is rough and backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affected the clinical application of this product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 200g of Artemisia annua, 267g of Five Fingers Mandarin, 134g of fenugreek, 200g of dog liver dish, 134g of licorice, 134g of Centella asiatica, 267g of Gangmei, and add Artemisia annua and lavender to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 700W, and the extraction is performed twice. 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressu...

Embodiment 2

[0033] Take 200g of Artemisia annua, 267g of Five Fingers Mandarin, 134g of fenugreek, 200g of dog liver dish, 134g of licorice, 134g of Centella asiatica, 267g of Gangmei, and add Artemisia annua and lavender to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent, the extraction pressure is 30MPa, the temperature is 50°C, and CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. Combine the extracts for 5 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, co...

Embodiment 3

[0036] Take 200g of Artemisia annua, 267g of Five Fingers Mandarin, 134g of fenugreek, 200g of dog liver dish, 134g of licorice, 134g of Centella asiatica, 267g of Gangmei, and add Artemisia annua and lavender to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 220min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 800W, and the extraction is performed twice. For 10 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduce...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and concretely relates to a preparation method of a cold tablet containing Artemisia carvifolia and holly root, and an application of the cold tablet. The preparation method of the cold tablet containing Artemisia carvifolia and holly root is characterized in that the cold tablet is prepared by using 200g of Artemisia carvifolia, 267g of Fructus Citri Sarcodactylis, 134g of Herba Moslae, 200g of Dicliptera chinensis, 134g of licorice root, 134g of Centella asiatica and 267g of holly root as raw medicines through supercritical extraction and microwave extraction, so the glycyrrhizic acid content is greatly improved. The invention also provides an application of the cold tablet in the preparation of mastocytoma cell P815 cell proliferation inhibition medicines.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Qingmei Ganmao tablet and its application in medicines for inhibiting the proliferation of mouse mastocytoma cells P815 cells. Background technique [0002] The standard number of Qingmei Ganmao Granules is WS-11318 (ZD-1318)-2002, which is recorded in the Spleen and Stomach Subvolume of the National Compilation of Chinese Patent Medicine Standards. It is made from 200g of Artemisia annua, 267g of Five Fingers Mandarin, 134g of Carrot, 200g of Dog Liver, 134g of Licorice, 134g of Centella asiatica, and 267g of Gangmei, which has cooling and antipyretic effects. For Fengreganmao, headache, cough, stuffy nose. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Qingmei Ganmao Granules. However, the method of extracting volatile oil and decoc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K36/752A61K9/20A61P11/00A61P35/00
Inventor 孙波
Owner JINAN XINQIDIAN MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com