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Application of cay10404 in the preparation of multiple myeloma drugs

1. The technology of CAY10404 and multiple myeloma, which is applied in the field of drug application for the treatment of malignant tumors, can solve the problems of the undisclosed application dose of CAY10404 multiple myeloma in medicine, and achieve strong targeting, tumor growth inhibition, and effect Mechanistically clear effect

Inactive Publication Date: 2016-03-23
CHINA PHARM UNIV +5
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The medical use and specific application dosage of CAY10404 for multiple myeloma are not disclosed in the prior art

Method used

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  • Application of cay10404 in the preparation of multiple myeloma drugs
  • Application of cay10404 in the preparation of multiple myeloma drugs
  • Application of cay10404 in the preparation of multiple myeloma drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 CAY10404 injection 5mg / 5ml

[0030] Take a total of 10g of CAY10404, add appropriate amount of excipients or not, adjust the pH to 3.5, make a sterilized aqueous solution, bottle, each 5mg / 5ml, 2000 in total.

Embodiment 2

[0031] Example 2 Compound CAY10404 / bortezomib injection CAY10404: 5mg; Bortezomib: 5mg; 10ml.

[0032] Take 10 g of CAY10404 and bortezomib respectively, add appropriate amount of auxiliary materials or not, make sterilized aqueous solution, bottle, and obtain 2000 sticks.

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Abstract

The invention discloses a medicine for treating multiple myeloma, and specifically relates to application of CAY10404 to prepare a pharmaceutical composition for treating multiple myeloma. CAY10404 is mainly used in tumor cell Wnt signal pathway and used to inhibit accumulation of beta-catenin protein in the pathway. The beneficial effects comprise that CAY10404 is strong in targeting ability and clear in action mechanism, and is mainly used in tumor cell Wnt signal pathway and used to inhibit accumulation of beta-catenin protein in the pathway so as to realize the purpose of inhibiting tumor growth. Compared with other medicines for treating multiple myeloma, such as doxorubicin, the medicine provided by the invention has relatively substantial action effect. Clinic tests show that the medicine has treatment effect on variety of multiple myeloma patients, and is relatively good in treatment effect on especially a patient subjected to bone marrow transplantation. Treatment for 30 examples of clinic test patients shows that the total effective rate is 96.7%. Additionally, the medicine has synergistic effect when used by combining bortezomib and doxorubicin and the like.

Description

technical field [0001] The invention belongs to the application field of medicines for treating malignant tumors, in particular to medicines for treating multiple myeloma. Background technique [0002] Many non-steroidal anti-inflammatory drugs (NSAIDs) are non-selective COX-1 and COX-2 inhibitors. At present, the inhibitory effect of NSAIDs on COX-1 and COX-2 is generally used by IC50COX-1 / IC50COX-2 The ratio indicates that the smaller the ratio of the two, the stronger the inhibitory effect of a certain drug on COX-1, and the greater the adverse reaction of the drug; on the contrary, the larger the ratio, the smaller the adverse reaction. CAY10404 (chemical name: 3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole) is currently one of the most effective selective COX-2 inhibitors, selective The index (SI; SI=IC50COX-1 / IC50COX-2) is greater than 500000, while celecoxib is about 400. The structural formula of CAY10404 is shown in formula I: the molecular formula...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/42A61K31/704A61K31/69A61P35/00
Inventor 杨烨万礼王旻顾春艳陆美玲
Owner CHINA PHARM UNIV
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