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Application of astaxanthin as antidepression medicine

An anti-depression, astaxanthin technology, applied in the field of medicine, to achieve the effect of ensuring reliability

Inactive Publication Date: 2014-06-18
BEIJING GRAGEN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are more than 30 patents on the use of astaxanthin in the world, see the attached table, but there is no report about the use of the compound astaxanthin in the treatment of depression by scholars

Method used

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  • Application of astaxanthin as antidepression medicine
  • Application of astaxanthin as antidepression medicine
  • Application of astaxanthin as antidepression medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: The effect of astaxanthin on the tail suspension experiment of animal depression model.

[0039] Animal CD1 mice, male, weighing 25-35 grams, were provided by Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., license number: SCXK (Beijing) 2011-0011. The animals were kept in separate cages with free water and feed, and the feed was provided by the Laboratory Animal Center of the Institute of Genetics, Chinese Academy of Sciences, and any common feed for the experimental mice could be used.

[0040] Test drug:

[0041] Astaxanthin was purchased from Shanghai Fusheng Industrial Co., Ltd.

[0042] The positive control, Imipramine hydrochloride, is a product of Sigma Company, the product number is I7379, and the batch number is O56K1380.

[0043] experiment equipment:

[0044] Crossbar, tape, Sumsung Intelli-200m digital video camera (Samsung, Korea), JUNSO multi-function timer.

[0045] Experimental steps:

[0046] Male CD1 mice were adaptively...

Embodiment 2

[0058] Embodiment 2 Mice forced swimming experiment

[0059] The animals were male CD1 mice, provided by Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., license number: SCXK (Beijing) 2011-0011. The animals were kept in separate cages one week before the experiment, the light and dark cycle was 12h / 12h, the room temperature was 20-22℃, and the animals were allowed to eat freely. Feed was provided by the Laboratory Animal Center, Institute of Genetics, Chinese Academy of Sciences.

[0060] Experimental drug:

[0061] Astaxanthin (astaxanthin), imipramine hydrochloride (Imipramine hydrochloride) is the same as Example 1

[0062] Test Instruments:

[0063] Glass cylinder (height 20cm, diameter 14cm); mouse open box (diameter 30cm, height 20cm, bottom 16 equal parts); thermometer; JUNSO multi-function timer.

[0064] Drug preparation is the same as the tail suspension experiment.

[0065] Astaxanthin mother solution: Astaxanthin is dissolved in a small amount o...

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Abstract

Application of astaxanthin as an antidepression medicine belongs to the field of medicine and is characterized in that astaxanthin or derivatives of astaxanthin is taken as pharmacological active component for preparing the antidepression medicine, wherein the derivatives mean pharmaceutically acceptable salts and esters of astaxanthin or glycosides prepared from astaxanthin and saccharide. The medicine is used to treat or prevent depression, and has the advantages of substantial antidepression effect, fast effectiveness, small side effect and the like, and thus the medicine is an excellent antidepression candidate medicine.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a rapid antidepressant drug with astaxanthin as the main component. Background technique [0002] Depression has become a common and frequently-occurring disease in modern society, and its incidence is still increasing. Symptoms are characterized by depressed mood, decreased interest, slowed thinking, and reduced speech and movement. Major depression is characterized by world-weariness or suicidal thoughts. The suffering caused by these diseases to patients and their families, as well as the loss to society, is unmatched by many other diseases. According to a report published by the World Health Organization (WHO), affective disorders have now become the fourth largest disease in the world, and the number of depression patients worldwide has reached 340 million. The current incidence of depression in China is about 4%. At least 26 million people in China suffer from depression, and the...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P25/24
Inventor 杜静
Owner BEIJING GRAGEN BIOTECH
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