A magnetic microsphere cleaning device for a fully automatic chemiluminescence immunoassay analyzer

Abstract

The invention discloses a magnetic microsphere cleaning device for a full-automatic chemiluminescent immunoassay instrument. The magnetic microsphere cleaning device comprises an outer ring, an inner ring, a dislocation mechanism, an electromagnet, a cleaning part and a controller. A plurality of reaction cups arrayed at intervals are arranged around the outer ring, and magnetic microspheres used for attracting a to-be-detected sample are placed in the reaction cups; the inner ring is coaxially arranged on the inner side of the outer ring, and a permanent magnet is arranged on one side of the inner ring; the electromagnet is positioned on one side of the outer ring and opposite to at least one of the reaction cups of the outer ring; the cleaning part is arranged above the outer ring and opposite to at least one of the reaction cups of the outer ring; the controller is used for controlling power on and off of the electromagnet and the dislocation mechanism. The cleaning device enables a magnetic field to be easily mastered by the aid of the electromagnet, the magnetic field can be automatically removed or adjusted when cleaning solution is injected, and consequently the magnetic microspheres can be completely cleaned to reduce impurity interference, and test precision of the instrument can be improved.

Description

technical field [0001] The invention relates to a medical device in the field of in vitro detection, in particular to a cleaning device in a fully automatic chemiluminescence immunoassay analyzer using magnetic bead particles as a reaction carrier. Background technique [0002] The automatic chemiluminescent immunoassay analyzer is an instrument that can perform immunological quantitative analysis on patient's body fluid samples, and can test anemia, cardiovascular disease, congenital diseases, sex hormones, infectious diseases, metabolic functions, tumor markers, therapeutic drugs Monitor and thyroid and other diseases. The application of automatic chemiluminescence immunoassay analyzer makes the inspection process fully automatic, improves the work efficiency of immunoassay, eliminates human subjective error, stabilizes the quality of immunoassay, and provides a reliable and efficient method for clinical immunoassay. way. [0003] In an automatic chemiluminescent immunoa...

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Problems solved by technology

[0005] But the prior art has the following defects: 1) when the magnetic microsphere solid phase carrier is cleaned, because it is attached to the cup wall, other magnetic microspheres except the surface of the magnetic microsphere layer are difficult to clean sufficiently, resulting in Insufficient cleaning

2) The magnetic microspheres are suspended in the liquid. Even under the magnetic field of the permanent magnet, the entire adsorption process usually takes tens of seconds, which greatly affects the work efficiency

[0006] In addition, a few cleaning devices using electromagnets to adsorb magnetic microspheres have been developed in recent years, but due to their overly complicated control circuits, it is difficult to achieve mass production, and the stability of the instruments needs to be further verified

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