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9-oxo-octadecadienoic acid (9-oxo-HODE) as biomarker for healthy ageing

A 9-HODE, oxo technology, applied in the field of improvement, can solve problems such as the comprehensive description of the molecular mechanism that has not yet been reported, and the lack of long-lived metabolic phenotype research.

Inactive Publication Date: 2014-12-10
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite these findings, a comprehensive delineation of the molecular mechanisms influencing the aging process has yet to be reported
Furthermore, metabolic phenotype studies on longevity are still lacking

Method used

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  • 9-oxo-octadecadienoic acid (9-oxo-HODE) as biomarker for healthy ageing
  • 9-oxo-octadecadienoic acid (9-oxo-HODE) as biomarker for healthy ageing
  • 9-oxo-octadecadienoic acid (9-oxo-HODE) as biomarker for healthy ageing

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Experimental program
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Embodiment

[0167] Subjects and Study Groups

[0168] Each individual and their family gave informed consent for the study to be conducted. In total, 541 subjects belonging to different age groups were enrolled for this study in northern Italy (including Bologna, Florence, Parma, Milan). The centenarian group consisted of 156 individuals (125 females and 31 males), the older group consisted of 363 individuals (205 females and 158 males), and the young adult group consisted of 22 individuals (10 women and 12 men).

[0169] The study protocol was approved by the ethics committee of the Sant'Orsola-Malpighi University Faculty of Medicine (Bologna, Italy). Resulting biological samples (serum and urine) were stored at -80°C until metabolomic analysis.

[0170] clinical chemistry

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Abstract

Using NMR / MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and / or avoiding ageing related chronic inflammatory disorders using 9-oxo-HODE as biomarker.

Description

technical field [0001] The present invention generally relates to healthy lifestyles and the prevention of aging-related chronic conditions. In particular, the invention relates to biomarkers and their use in detecting lifestyle improvements. Thus, the present invention provides, for example, 9-oxo-octadecadienoic acid (9-oxo-HODE) as a biomarker and also provides the use of the biomarker 9-oxo-octadecadienoic acid (9 -oxo-HODE) A method of diagnosing a lifestyle that allows delaying and / or avoiding aging-related chronic inflammatory conditions. Background technique [0002] Aging is defined as a time-dependent decline in functional capacity and stress resistance, associated with increased risk of morbidity and mortality. Furthermore, the human aging phenotype is very heterogeneous and can be described as a complex mosaic resulting from the interaction of various environmental, stochastic and genetic-epigenetic variables. Decades of aging research have uncovered hundreds ...

Claims

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Application Information

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IPC IPC(8): G01N33/68A23L33/00
CPCG01N2405/00G01N33/6893A23L33/30Y10T436/182Y10T436/24G01N33/49G01N33/6848A23V2002/00G01N33/6812G01N33/92G01N2800/50G01N2800/7095
Inventor S·科里诺I·蒙托柳鲁拉F-P·马丁P·A·盖S·A·D·莱兹
Owner NESTEC SA
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