Composition comprising Rhizoma Coptidis, Cortex Phellodendri and Fructus Gardeniae and For Treating Neurodegenerative Diseases

Abstract

This invention is in the field of pharmaceuticals, health supplements and chemical industries. In particular, this invention relates a herbal composition that compensates the A[beta] increasing effects of existing treatment, and on the regulatory processing of amyloid-[beta] protein precursor (APP), therefore presenting a significantly more potent treatment for neurodegenerative diseases that does not associate with any [beta]-amyloid increasing effect.

Description

[0001] Cross-references to related applications [0002] This application claims priority to U.S. Provisional Patent Application 61 / 834,437, filed June 13, 2013, and U.S. Provisional Patent Application 61 / 836,118, filed June 17, 2013, the disclosures of which are incorporated by reference This article. technical field [0003] The present invention is in the field of pharmaceuticals, health nutritional supplements and the chemical industry. In particular, the present invention provides a herbal composition having a remarkably effective therapeutic effect for the treatment of neurodegenerative diseases, independent of any β-amyloid-increasing effect exhibited by existing treatments. Background technique [0004] Extracellular senile plaques and phosphorylated tau-associated neurofibrillary tangles (NFTs) are two typical microscopic lesions of Alzheimer's disease (AD). Senile plaques contain a dense core of amyloid-β (Aβ) surrounded by dystrophic neurites (see Selkoe DJ (200...

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Problems solved by technology

Qiu et al. reported that HLJDT reduced Aβ plaques and improved memory in APP / PS-1 mice, but the authors of this paper did not mention quantification of Aβ burden

Qiu et al. also reported that HLJDT reduced APP mRNA levels, but did not measure the effect of HLJDT on protein levels of full-length (Fl) APP, Aβ, and soluble forms of APP (i.e., sAPPα and sAPPβ)

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