Devices and methods for the treatment of vascular disease

Abstract

Apparatus and methods are provided for delivering fluid into a body lumen. The apparatus may include a catheter including proximal and distal ends, a fluid delivery lumen extending from the proximal end to a transit port on a distal portion of the catheter, and an inflatable infusion element on the distal portion such that an interior of the inflatable infusion element communicates with the fluid delivery lumen. During use, a distal end of the catheter is introduced into a lumen or conduit with the inflatable infusion element in a collapsed condition, the inflatable infusion element is expanded to an expanded condition to partially or totally occlude the lumen or conduit, and fluid is infused from the catheter into the lumen or conduit proximally relative to the inflatable infusion element while the inflatable infusion element remains in the expanded condition.

Description

[0001] Related application materials [0002] This application claims the benefit of co-pending U.S. Provisional Application Serial Nos. 61 / 694,922 (filed August 30, 2012) and 61 / 786,499 (filed March 15, 2013), the entire disclosures of which are expressly incorporated herein by reference . field of invention [0003] The field of the invention relates generally to medical devices and methods, and more particularly to catheter-based devices and methods for treating diseased vasculature. Background of the invention [0004] Minimal invasive diagnostic and therapeutic interventions for the treatment of vascular disease generally utilize a combination of catheter and wire-based devices. In general percutaneous vascular interventions, exemplary procedural elements may include the following: use of fluoroscopy and injection of contrast imaging agents through the lumen of a guide catheter or sheath, prior to, during, and / or after treatment, to obtain clear image of the vasculatu...

AI Technical Summary

Problems solved by technology

While this approach offers an alternative to using the larger or higher profile introducer tubes or sheaths used with the antegrade approach, the transpedal approach presents several drawbacks

First, the contrast agent may not be easily injected through the treatment device, as previously mentioned, inhibiting effective imaging of the treatment area

Second, there is no other way to obtain selective angiograms when the therapeutic device has been inserted directly into the artery without an entry site sheath

Third, since transpedal entry provides a retrograde approach, injection of lower volumes and concentrations of contrast media and lower injection flow rates against entry into the bloodstream inhibit angiographic imaging of target vessels and lesions

However, these methods can present safety concerns, prolong procedure time, and / or increase procedure cost

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