Single-side touch liquid type quartz crystal microbalance detector

A quartz crystal and detection device technology, applied in the field of sensing and detection, can solve the problems of large size, waste of solution, and the inability to disassemble and reuse the quartz wafer sensor, and achieve the effect of small size, reduced usage, and miniaturized transformation

Inactive Publication Date: 2015-07-22
谭亮 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] One of the purposes of the present invention is to provide a simple structure, low liquid consumption, etc. to solve the problems of large waste of solution in the experiment due to the large size of the quartz crystal microbalance detection device, and the fact that the quartz wafer sensor can hardly be disassembled and reused. , The sensor can be easily disassembled, and the single-sided liquid-contact quartz crystal microbalance detection device with high stability has realized the miniaturization of the QCM detection device, and ensured the stability and reliability of the detection process. Detection of micro or trace chemical small molecules, biological macromolecules, etc.

Method used

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  • Single-side touch liquid type quartz crystal microbalance detector
  • Single-side touch liquid type quartz crystal microbalance detector
  • Single-side touch liquid type quartz crystal microbalance detector

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Experimental program
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Embodiment 1

[0038] Such as figure 1 , 2 A schematic diagram of the structure of a single-side liquid-contact type quartz crystal microbalance detection device of the present invention shown in and 3, a single-side liquid-contact type quartz crystal microbalance detection device includes a detection pool 1 and a quartz wafer sensor 2, and the detection pool Including cover 11, liquid storage tank 12, ring gasket I13, ring gasket II131;

[0039] Such as image 3As shown, the quartz wafer sensor 2 includes a quartz wafer 21 and a chassis 22, the quartz wafer 21 is provided with a front electrode 211 and a reverse electrode 212, and the chassis is provided with a left electrode rod 221 and a right electrode rod 222 , the left electrode rod 221 and the right electrode rod 222 are respectively connected to the front electrode 211 and the reverse electrode 212 through a metal wire and conductive glue;

[0040] Such as Figure 4 As shown, the center of the cover 11 is provided with a cylindri...

Embodiment 2

[0055] Embodiment 2 utilizes the detection device described in embodiment 1 to carry out real-time monitoring bovine serum albumin (BSA) adsorption and Cu on the QCM bare gold electrode surface 2+ Bonding and Precipitation Reactions

[0056] Utilize described invention to carry out real-time monitoring the adsorption of bovine serum albumin (BSA) on the surface of QCM bare gold electrode and Cu 2+ bonding and precipitation reactions. The annular gasket II131, quartz wafer 21, annular gasket I13, and cover 11 are installed in sequence on the sample outlet 123 side of the sensing contact hole 122 of the liquid holding pool 12, and the first screw rod 14 and The second screw rod 15 passes through the first cover through hole 113 and the second cover through hole 114 respectively, and is screwed into the left threaded port 124 and the right threaded port 125 on the liquid holding pool 12 to ensure that the quartz Sealed snap-fit ​​of the wafer 21. Slowly inject 1.4mL pH 7.0PBS ...

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Abstract

The invention belongs to the technical field of sensing detection, and particularly relates to a single-side touch liquid type quartz crystal microbalance detector. The single-side touch liquid type quartz crystal microbalance detector comprises a detection tank and a quartz crystal wafer sensor, wherein the detection tank comprises a seal cover, a liquid filling tank, an annular washer I and an annular washer II, wherein the center of the seal cover is provided with a cylindrical groove; a first seal cover through hole and a second seal cover through hole are respectively formed in two sides of the cylindrical groove; the liquid filling tank is of an L shaped structure, and is provided with a sample charge hole and a sensing contact hole which are perpendicular to each other and are communicated with the cylindrical through hole; a left threaded hole and a right threaded hole are respectively formed in two sides of the sensing contact hole of the liquid filling tank. According to the single-side touch liquid type quartz crystal microbalance detector, the design is reasonable, the structure is simple, the size is small, the liquid consumption amount is small, and the sensor can be detached and can be used repeatedly, and the stability is relatively high.

Description

technical field [0001] The invention belongs to the technical field of sensing and detection, and in particular relates to a single-sided liquid-contacting type quartz crystal microbalance detection device. Background technique [0002] Quartz crystal microbalance QCM (Quartz Crystal Microbalance), as a micromass sensor, has the advantages of simple structure, low cost, high sensitivity, and measurement accuracy can reach nanogram level, and is widely used in chemistry, physics, biology, medicine and surface science In other fields, it is used for composition analysis of gas and liquid, measurement of micro mass, detection of film thickness, etc. According to needs, the metal electrode can also be selectively coated to further broaden its application. For example, if a layer of selective adsorption film is added on the surface of the electrode, it can be used to detect the chemical composition of the gas or monitor the progress of the chemical reaction. With the vigorous d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N5/00
Inventor 谭亮罗弋群刘同
Owner 谭亮
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