Isolation valve of a freeze-drying sampling device and its operating method

Abstract

The invention relates to an isolation valve of a freeze-drying and sampling device and an operation method of the isolation valve. The isolation valve mainly comprises a valve plate, a lifting push rod, a shaft sleeve, a connection rod, an eccentric ring, a check ring, a spring clamping ring, a center shaft, a rotary shaft, a bearing block, a bearing, a sleeve pipe and a handle. The operation method mainly includes the steps of opening and closing of the isolation valve and the like. The isolation valve is disposed between a freeze-drying box and a sampling container, and the isolation of the vacuum environment and the normal-pressure environment is achieved in the sampling process; and besides, the problem that the internal structure of a common vacuum gate valve cannot meet the sterile requirement of drying of sterile preparation drugs or biological agents on equipment structures is solved.

Description

technical field [0001] The invention belongs to the technical field of freeze-drying equipment, and relates to a sampling device of vacuum freeze-drying equipment, in particular to an isolation valve of the freeze-drying sampling device and an operating method thereof. Background technique [0002] Vacuum freeze-drying, also known as freeze-drying, is a process for drying substances, usually used for the drying of pharmaceuticals or biological preparations of sterile preparations. In this freeze-drying process, the substance is first frozen, and then the moisture in the substance is removed by sublimation and desorption in a vacuum environment, so that the moisture is reduced to the level required for storage. Freeze-drying of substances is usually done on slabs inside a freeze-drying cabinet. In order to study the laws of freeze-crystallization, sublimation drying and desorption drying of substances in the process of freeze-drying, and to explore more suitable freeze-dryin...

AI Technical Summary

Problems solved by technology

The first form is to use the structure of the sample lifting device to isolate the part of the sampling container, so as to realize the isolation of the vacuum environment and the normal pressure environment during the sampling process, but this structure cannot eliminate the sampling bottle clamp and the sample lifting device. Linear motion produces the effect of gas leakage, and if the seal of this linear motion part fails, it will also cause the entire freeze-drying process to fail

The second form is to install an ordinary vacuum gate valve between the sampling container and the freeze-drying box. Although the vacuum environment can be isolated from the normal pressure environment during the sampling process, it can also eliminate the friction caused by the linear motion of the sampling bottle clamp. Influenced by gas leakage, but the internal structure of ordinary vacuum gate valves is difficult to meet the aseptic requirements for equipment structure when drying sterile preparations of drugs or biological preparations

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