A drug for treating Parkinson's disease

A technology for Parkinson's disease and medicine, which is applied in the field of traditional Chinese medicine compositions made from traditional Chinese medicinal materials, can solve the problems of elimination, many medicinal flavors, large compound prescriptions, etc. Effect

Active Publication Date: 2018-04-17
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing Chinese patent medicines for the prevention and treatment of Parkinson's disease generally have large compound prescriptions, many medicinal flavors, complex active ingredients, unstable production process, difficult quality control, difficult to guarantee curative effect and other defects, difficult to develop in the market, and will even be gradually eliminated by the market

Method used

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  • A drug for treating Parkinson's disease
  • A drug for treating Parkinson's disease
  • A drug for treating Parkinson's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0191] Embodiment 1 (granule):

[0192] Weigh 9kg of red ginseng, 12kg of Radix Polygoni Multiflori, 9kg of Ginkgo biloba leaves and 9kg of Radix Ophiopogon japonicus, add 10 times the amount of water to decoct 3 times, keep boiling slightly for 2.0 hours after the first boiling, and keep boiling slightly for 1.5 hours after the second boiling, Keep simmering for 1.0 hour after the third boil. Then combine the decoctions, filter and concentrate the filtrate under reduced pressure at 80°C to a clear paste with a relative density of 1.25, put it in a decompression drying oven at 60°C to dry the paste, and grind it into fine powder. Add appropriate amount of dextrin and starch to 10kg in the obtained dry paste fine powder, add 75% alcohol again to make granules, then dry, granulate, and pack into 10g / bag (every containing medicine dry powder about 3.3g).

Embodiment 2

[0193] Embodiment 2 (granule)

[0194] Weigh 7.800kg of red ginseng, 13.016kg of Radix Polygoni Multiflori, 9.379kg of ginkgo leaves and 8.805kg of Radix Ophiopogon japonicus, add 10 times the amount of water to decoct 3 times, keep boiling slightly for 2.0 hours after the first boiling, and keep slightly boiling after the second boiling. Boil for 1.5 hours, keep boiling slightly for 1.0 hour after the third boil. Then combine the decoctions, filter and concentrate the filtrate under reduced pressure at 80°C to a clear paste with a relative density of 1.25, put it in a decompression drying oven at 60°C to dry the paste, and grind it into fine powder. Add appropriate amount of dextrin and starch to 10kg in the obtained dry paste fine powder, add 75% alcohol again to make granules, then dry, granulate, and pack into 10g / bag (every containing medicine dry powder about 3.3g).

Embodiment 3

[0195] Embodiment 3 (granule)

[0196] Weigh 10.140kg of red ginseng, 11.505kg of Radix Polygoni Multiflori, 8.385kg of ginkgo biloba leaves and 8.970kg of Radix Ophiopogon japonicus, add 10 times the amount of water to decoct 3 times, keep boiling slightly for 2.0 hours after the first boiling, and keep slightly boiling after the second boiling. Boil for 1.5 hours, keep boiling slightly for 1.0 hour after the third boil. Then combine the decoctions, filter and concentrate the filtrate under reduced pressure at 80°C to a clear paste with a relative density of 1.25, put it in a decompression drying oven at 60°C to dry the paste, and grind it into fine powder. Add appropriate amount of dextrin and starch to the obtained dry cream powder to 10kg, add 75% alcohol to make granules, then dry, granulate, and pack into 10g / bag (every containing about 3.3g of drug dry powder).

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Abstract

The invention discloses a medicine for treating Parkinson's disease. The medicine is composed of active ingredients and medically acceptable excipients, wherein the active ingredients are made of raw materials in the following percentages by weight: 20-26% of ginseng, Make Polygonum multiflorum 28~34%, Ginkgo biloba 20~26%, Ophiopogon japonicus 20~26%. The medicine of the present invention can be oral preparations such as granules, capsules, concentrated pills or tablets, and has the advantages of quick improvement of symptoms and short course of treatment through clinical verification. The pharmaceutical raw material of the invention has few types, simple and easy-to-operate preparation method, and has wide application value.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition prepared from raw materials of Chinese medicinal materials. Background technique [0002] Parkinson's disease (PD) is a common degenerative disease of the central nervous system in middle-aged and elderly people. The main pathological changes are the progressive degeneration and loss of striatal dopamine (DA) neurons in the substantia nigra compacta of the midbrain, and the loss of dopamine content in the striatum. Central nervous system degenerative disease with abnormal gait as the main symptom, unable to take care of oneself, has the characteristics of long disease course and low cure rate, which seriously affects the quality of life of patients; the prevalence rate of people over 65 years old can reach more than 1.7% , and there is an increasing trend year by year. At present, the number of PD patients in my country has...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61P25/16
Inventor 贝伟剑郭姣
Owner GUANGDONG PHARMA UNIV
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