A kind of preparation method and application of apricot rabbit ear wind soft capsule

A technology of apricot-flavored rabbit ears and soft capsules, which is applied in capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve the problems of large dosage, backwardness, and many impurities for patients, and achieve the effect of reducing dosage

Active Publication Date: 2017-09-05
云南云龙制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report on the use of microwave technology in the extraction and preparation of Xingxiang Tuerfeng Soft Capsules. However, methods such as water boiling and alcohol precipitation are used. The process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product

Method used

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  • A kind of preparation method and application of apricot rabbit ear wind soft capsule
  • A kind of preparation method and application of apricot rabbit ear wind soft capsule
  • A kind of preparation method and application of apricot rabbit ear wind soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Take 3000g of Apricot Rabbit’s Ear Wind, pulverize it, add 2L of 70% ethanol, put it into a microwave extraction device for microwave extraction, extraction power is 400W, extract 2 times, each time for 4 minutes, combine the extracts, concentrate, add to On a D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate, add an appropriate amount of soybean oil, grind and mix evenly, and press into 800 soft capsules to obtain the final product.

Embodiment 2

[0016] Example 2: Take 3000g of Apricot Rabbit’s Ear Wind, pulverize it, add 2L of 70% ethanol, put it into a microwave extraction device and carry out microwave extraction, extraction power is 500W, extract 2 times, each time for 6 minutes, combine the extracts, concentrate, add to On a D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate, add an appropriate amount of soybean oil, grind and mix evenly, and press into 800 soft capsules to obtain the final product.

Embodiment 3

[0017] Example 3: Take 3000g of apricot rabbit ear wind, pulverize, add 2L of 70% ethanol, put it into a microwave extraction device for microwave extraction, extraction power 600W, extract 2 times, each 8 minutes, combine the extracts, concentrate, add to On a D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate, add an appropriate amount of soybean oil, grind and mix evenly, and press into 800 soft capsules to obtain the final product.

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Abstract

The invention provides a method for preparing Xingxiang Rabbit's Ear Feng Soft Capsules, which is prepared from 3000 g of Xingxiang Rabbit's Ear Feng as a raw material drug and prepared by microwave extraction, so that the content is greatly improved and the dosage is reduced. The invention also provides Application of Xingxiang Tuerfeng Soft Capsules in the preparation of drugs for increasing red blood cells and drugs for tolerance to hypoxia.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Xingxiangtuerfeng soft capsules. Background technique [0002] Xingxiang Tuerfeng Soft Capsules are recorded in the ministerial standards. The prescription is Xingxiang Rabbit's Earfeng 3000g. Take 3000g of Xingxiang Rabbit's Earfeng and add 10 times the amount of water to extract three times, each time for 2 hours, combine the decoction, and concentrate the filtrate to a relative density of 1.10 -1.20 (60°C) clear paste, add ethanol to make the alcohol content reach 70%, let it stand overnight, and separate the supernatant; wash the precipitate twice with 70% ethanol, and combine the washing liquid and the supernatant. The ethanol is recovered and concentrated to a relative density of 1.35 (60°C), an appropriate amount of soybean oil is added, ground and mixed evenly, and compressed into 1000 soft capsules...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K9/48A61P7/06A61P39/00
Inventor 杨建云
Owner 云南云龙制药股份有限公司
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