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Traditional Chinese medicine composition used for controlling radiothermitis and application thereof

A radiation dermatitis and composition technology, which is applied in the field of medicine, can solve the problems of triethanolamine cream, the lack of prevention of radiation dermatitis, and the economic and mental burden of patients, so as to achieve strong heat-clearing and detoxifying effects, prevent and treat radiation dermatitis, and protect newborns. organization effect

Inactive Publication Date: 2015-12-30
FUZHOU GENERAL HOSPITAL OF NANJING MILITARY COMMAND P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to routine care, the only marketed drug for the treatment of radiation dermatitis is triethanolamine cream, which has deep hydration and can help eliminate exudate, but it has no preventive effect on radiation dermatitis, and triethanolamine cream is irritating Larger, it will cause different degrees of pain or itching after the skin is applied, and in a few cases, an al

Method used

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  • Traditional Chinese medicine composition used for controlling radiothermitis and application thereof
  • Traditional Chinese medicine composition used for controlling radiothermitis and application thereof
  • Traditional Chinese medicine composition used for controlling radiothermitis and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0041] 1) Take 10g of dried aloe vera as the first group of traditional Chinese medicines, 5g of white peony root, 5g of scutellaria baicalensis, and 5g of Phellodendron Phellodendri as the second group of traditional Chinese medicines, 10g of coix seed as the third group of traditional Chinese medicines, and 6g of mint as the fourth group of traditional Chinese medicines; mix the four groups of traditional Chinese medicines After that, add water to soak for 0.5h according to the weight-to-volume ratio of 1:10, then reflux extraction for 3 times, each time for 0.5h, and then filter, extract with water and precipitate with alcohol, then concentrate under reduced pressure to obtain 5g of the traditional Chinese medicine composition;

[0042] 2) After melting 0.5g of polyoxyethylene 40 hydrogenated castor oil in a beaker in a water bath at 30°C, add the traditional Chinese medicine composition obtained in step 1), and dissolve it by ultrasonic to obtain a Chinese medicinal liquid; ...

Embodiment 2

[0046] 1) Take 60g of fresh aloe vera as the first group of traditional Chinese medicines, 30g of honeysuckle and 20g of Scutellaria baicalensis as the second group of traditional Chinese medicines, 15g of angelica and 25g of Angelica dahurica as the third group of traditional Chinese medicines, and 20g of borneol as the fourth group of traditional Chinese medicines; wash and squeeze the fresh aloe vera products juice, double-layer gauze filtration, and filtrate concentration to obtain 15g of aloe concentrate; the other three groups of Chinese medicines except the first group of Chinese medicines were added with mass concentration of 90% ethanol at a weight-to-volume ratio of 1:8, soaked for 1h, and then refluxed Extract 2 times, 1.5h each time, filter and concentrate under reduced pressure to obtain 35g of Chinese medicine extract;

[0047] 2) Put 2.5g of chitosan in a beaker, add 40mL of distilled water to swell for 20 minutes, add 0.5g of glacial acetic acid, and stir while ...

Embodiment 3

[0050]1) Take 20g of aloe extract as the first group of traditional Chinese medicines, 20g of honeysuckle and 15g of Coptis chinensis as the second group of traditional Chinese medicines, 30g of coix seed as the third group of traditional Chinese medicines, and 10g of frankincense as the fourth group of traditional Chinese medicines; dissolve the aloe extracts in heated water to obtain aloe vera Concentrated solution: After mixing the other three groups of traditional Chinese medicines except the first group of traditional Chinese medicines, add ethanol with a mass concentration of 10% according to the weight-to-volume ratio of 1:20, soak for 3 hours, then reflux for 2 hours, filter and mix with aloe concentrate , concentrated under reduced pressure to obtain 30g Chinese medicine composition;

[0051] 2) Put 10 g of polysorbate 80 in a beaker, add the Chinese medicine composition obtained in step 1), and dissolve it by ultrasonic to obtain a Chinese medicine liquid;

[0052] 3...

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Abstract

The invention discloses a traditional Chinese medicine composition used for controlling radiothermitis and application thereof. The composition is prepared by performing extraction and concentration on four groups of traditional Chinese medicines. The first group of traditional Chinese medicine is aloe; the second group of traditional Chinese medicines comprise one or more of flos lonicerae, paeoniae radix alba, radix scutellariae, phellodendri chinensis cortex and rhizoma coptidis; the third group of traditional Chinese medicines comprise one or more of radix angelicae sinensis, semen coicis, radix ampelopsis, angelicae dahuricae radix and radix sophorae flavescentis; and the forth group of traditional Chinese medicines comprise one or more of mentha haplocalyx Briq., borneolum syntheticum , myrrh and olibanum. The employed traditional Chinese medicines are all bitter and cold medicines, are strong in effects of clearing heat and detoxifying, also possesses effects of cooling blood and healing wound, contains multiple effective compositions with effects of resisting oxidation, diminishing inflammation, resisting bacteria and the like, can be used to prepare external-use preparations such as gelata, cream and the like for effectively controlling radiothermitis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition for preventing and treating radiation dermatitis and its application. Background technique [0002] Radiation dermatitis is an inflammatory lesion of the skin and mucous membranes caused by radiation (mainly β and γ rays and X-rays). The disease is mainly seen in patients receiving radiation therapy, those who are engaged in radiation work without strict protection, and soldiers and civilians exposed to radiation in nuclear accidents. The degree of damage is positively correlated with the radiation dose. The common symptoms of radiation dermatitis include erythema, desquamation, edema, ulcer, local skin bleeding and infection, etc., which bring great pain to patients, and some patients interrupt radiotherapy because they cannot tolerate it. [0003] At present, there is still a lack of effective means to prevent and treat r...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P17/16A61K31/045
Inventor 宋洪涛刘志宏张晶张敏新范成龙叶小红
Owner FUZHOU GENERAL HOSPITAL OF NANJING MILITARY COMMAND P L A
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