Combination therapeutics and methods for the treatment of neurodegenerative and other diseases

A technology for neurodegeneration and disease, applied in the direction of neurological diseases, drug combinations, sensory diseases, etc.

Inactive Publication Date: 2016-01-06
APHIOS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Very limited means currently exist to treat these diseases

Method used

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  • Combination therapeutics and methods for the treatment of neurodegenerative and other diseases
  • Combination therapeutics and methods for the treatment of neurodegenerative and other diseases
  • Combination therapeutics and methods for the treatment of neurodegenerative and other diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0058] Retinoic acid enhances bryostatin-1-mediated alpha-secretase activity. image 3 showed that bryostatin-1-induced sAPP-a formation in SH-SY5Y neuroblastoma cells was increased by 2 μM and 4 μM retinoic acid at 3 hours. Retinoic acid, an ADAM10 / α-secretase inducer, increases sAPP-a production by SH-SY5Y cells. Left panel shows 6E10 western blot of sAPP-a, right panel shows densitometric analysis. *-p<0.05 vs. control, **-p<0.01 vs. control, n=3; and

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Abstract

Embodiments of the present invention are directed to the administration of bryostatins and bryostatins and retinoids for the treatment of disease responsive to increases in alpha secretase activity. Inventions of the present application are directed to the treatment of neuro-degenerative diseases such as Hutchinson Disease, Parkinson's disease, Down's syndrome and Alzheimer's disease and virus latency diseases such as HIV and Herpes, cancers such as prostate, melanomas, lymphomas and renal cancers, esophageal and opthalmic diseases such as glaucoma.

Description

[0001] related application [0002] This application claims the benefit of US Provisional Patent Application No. 61 / 730,761, filed November 28, 2012, which is hereby incorporated by reference in its entirety. [0003] Statement on Federal Support [0004] This invention was made with federal support including National Institutes of Health Grant No. 1R44AG034760-01A1. technical field [0005] The invention of the present application is directed to the treatment of neurodegenerative diseases, such as Hutchinson's disease, Parkinson's disease, Down's syndrome (Down's syndrome) and Alzheimer's disease (Alzheimer's disease) ); and viral latent diseases, such as HIV and herpes; cancers, such as prostate cancer, melanoma, lymphoma, and kidney cancer; esophageal and eye diseases, such as glaucoma. Background technique [0006] Neurodegenerative diseases such as Alzheimer's disease, Hutchinson's Disease, Parkinson's disease, Kuru's disease (Kuru), Creutzfeldt-Jakobdisease and ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357
CPCA61K31/203A61K31/365A61K9/5153A61K9/0095A61K9/4858A61K9/4875A61K31/352A61P25/14A61P25/16A61P25/28A61P27/02A61P31/12A61P31/18A61P31/22A61P35/00A61P43/00A61K2300/00
Inventor T.P.卡斯托尔
Owner APHIOS
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