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Method of using dopamine for rapidly crosslinking chitosan to prepare hemostatic sponge

A technology of cross-linking chitosan and hemostatic sponge, applied in medical science, absorbent pads, bandages, etc., can solve problems such as cytotoxicity

Active Publication Date: 2016-02-24
深圳市和福汇生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of cross-linking agent has certain cytotoxicity, which

Method used

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  • Method of using dopamine for rapidly crosslinking chitosan to prepare hemostatic sponge
  • Method of using dopamine for rapidly crosslinking chitosan to prepare hemostatic sponge

Examples

Experimental program
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Effect test

Embodiment 1

[0021] 1) Weigh 5.00g chitosan hydrochloride (deacetylation degree is 85%) and dissolve it in 28mL deionized water, stir for 10min, a yellow viscous liquid appears; weigh 2g glycerin, dissolve it with 1mL deionized water; weigh Dissolve 1 g of poloxamer 407 in 20 mL of deionized aqueous solution, stir until completely dissolved, weigh 0.50 g of dopamine hydrochloride, and add it to the dissolved poloxamer 407 solution; 407 and dopamine hydrochloride solution were added to the chitosan hydrochloride solution and stirred for 20 min;

[0022] 2) Weigh 0.04g sodium periodate, dissolve it with 1mL deionized water and quickly add it to the foaming solution in step 1), and continue stirring for 15 minutes; pour the foaming solution obtained by stirring into a silica gel mold, and quickly transfer it to Freeze in a -30°C refrigerator for 24 hours; take the obtained sample out of the silica gel mold, transfer to a freeze dryer for freeze drying for 24 hours, and obtain a hemostatic spo...

Embodiment 2

[0024] Preparation of dopamine-crosslinked chitosan hemostatic cotton in Tris·HCl buffer solution: all the solvent water used in Example 1 was replaced by Tris·HCl buffer solution with pH=8.0, and other experimental conditions were the same as in Example 1.

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Abstract

The invention discloses a method of using dopamine for rapidly crosslinking chitosan to prepare hemostatic sponge, and belongs to the field of biomedical materials. The dopamine is adopted to react with amidogen on a chitosan chain, and meanwhile a self-polymeric reaction is performed, so that chitosan chain sections are crosslinked to form a cross-linked network structure, and the obtained chitosan sponge has the certain mechanical strength. In the reaction process, the oxidizing agent sodium periodate is added to accelerate the reaction, and therefore the time spent for preparing the chitosan hemostatic sponge can be greatly shortened. The chitosan hemostatic sponge has the good biocompatibility, also has the strong water expansion performance, mechanical performance, water retention and moistening performance and biodegradability, has the good analgesic and hemostatic effects, prevents wound contamination and infection, promotes healing of injured tissue, and can be possibly applied to clinical first aid and hemostasis.

Description

technical field [0001] The invention relates to a method for preparing a hemostatic sponge by rapidly cross-linking chitosan with dopamine, which belongs to the field of biomedical materials. Background technique [0002] If the bleeding caused by trauma is not stopped and bandaged in time, it will seriously threaten people's health and even life. Timely and effective hemostasis is very important for stabilizing the injury, saving the lives of the wounded, and creating conditions for follow-up treatment. [0003] Chitosan is a natural high molecular polymer, which belongs to amino polysaccharide. It is the only alkaline polysaccharide with cationic charge found so far. Chitosan can achieve the effect of hemostasis through the interaction between it and the red blood cell membrane, mainly the agglutination of red blood cells. However, the mechanical strength of pure chitosan sponge is poor, and the hemostatic effect is very limited, and the hemostatic effect is not good fo...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42
Inventor 徐福建胡浩罗旭
Owner 深圳市和福汇生物科技有限公司
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