Application of Physalis P in the Preparation of Medicines for Treating Chronic Obstructive Pulmonary Disease

A technology for chronic obstructive pulmonary disease and physalicylic acid, which can be used in the field of biomedicine to solve the problems of lack of related drugs in chronic obstructive pulmonary disease

Active Publication Date: 2017-10-17
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides an application of Physalis P in the preparation of medicines for treating chronic obstructive pulmonary disease, so as to solve the problem of lack of relevant medicines for the treatment of chronic obstructive pulmonary diseases at present

Method used

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  • Application of Physalis P in the Preparation of Medicines for Treating Chronic Obstructive Pulmonary Disease
  • Application of Physalis P in the Preparation of Medicines for Treating Chronic Obstructive Pulmonary Disease
  • Application of Physalis P in the Preparation of Medicines for Treating Chronic Obstructive Pulmonary Disease

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: The preparation method of compound physalicin P involved in the present invention is as follows:

[0014] Take 100kg of dried Physalis medicinal material (persistent calyx with fruit), add 80% ethanol (v / v) to reflux for extraction, reflux for 2 hours each time, and reflux 3 times to obtain 2.0kg of alcohol extraction extract, suspend the extract in Add appropriate amount of water, add 1.5 times the volume of n-hexane to extract three times, and discard the n-hexane layer. The water layer part was adsorbed by AB-8 macroporous adsorption resin, eluted with water, 40% and 90% ethanol in sequence, and the 90% ethanol eluted part was collected. Concentrate under reduced pressure and evaporate to dryness to obtain 1.2kg of powder. Add it to a silica gel column, elute with dichloromethane-methanol (90:10~20:80) gradient, collect the eluate of dichloromethane-methanol (55:45~40:60), recover to dryness, acetone Recrystallization yielded 30.6 g of Physalis P. Wh...

Embodiment 2

[0017] Embodiment 2: The preparation of the compound Physalis P tablet involved in the present invention: get 20 grams of Physalis P, add 80 g of starch, mix evenly, spray into 70% ethanol as wetting agent, make soft material; Pass through a 20-mesh sieve to obtain wet granules; dry at 60°C, turn over every 30 minutes, and control the moisture content at 1% to 3%. Add magnesium stearate powder, mix well, and press into 1000 tablets.

Embodiment 3

[0018] Embodiment 3: the preparation of the compound Physalis P capsules involved in the present invention: the raw and auxiliary materials are all passed through No. 5 sieve, to facilitate mixing completely and evenly, take Physalis P 40g, starch 200g, mix uniformly, Pack 1000 capsules.

[0019] Further illustrate the effect of the present invention by pharmacodynamic test below.

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Abstract

The invention discloses application of physalin P in preparing medicine for treating the chronic obstructive pulmonary disease and belongs to the biomedical field. The Chinese medicine monomer physalin P is adopted for animal model experiments, and it is proved through experiment results that the physalin P has a protection effect on the lung function in an experiment model for the chronic obstructive pulmonary disease caused by exposure of cigarette smoke, and a reverse effect on lung pathological changes of rats; an inhibiting effect on expression of the proinflammatory factor IL-6 induced by cigarettes in COPD rat serum and BALF is achieved, and a prompting effect on expression of the inflammation inhibiting factor IL-10 is achieved, and thus trachea inflammation is relieved. The physalin P serves as the medicine active ingredient, and clinical guidance and a base are provided for preventing and treating COPD, so that the pain of patients is relieved, and the body health and living quality of the patients are improved.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the new medicinal use of Physalis P, an effective component of traditional Chinese medicine, and in particular to the application of Phosphatrin P in the preparation of medicines for preventing and treating chronic obstructive pulmonary disease. Background technique [0002] Chronic Obstructive Pulmonary Disease (COPD) is a chronic airway inflammatory disease characterized by incompletely reversible airflow limitation that often develops progressively. The main clinical symptoms of COPD are chronic cough, expectoration, shortness of breath or dyspnea, wheezing and chest tightness. As the disease progresses, systemic inflammatory reactions will also occur, seriously affecting the patient's working ability and quality of life. The incidence of COPD is high, and smoking is the most important risk factor for COPD. The incidence rate of people over 40 years old in China is 8.2%, while that in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/585A61P11/00
CPCA61K31/585
Inventor 王放郑敬彤路艳娇张超王国强熊凌锌关雪娃陈芳王婷刘金平
Owner JILIN UNIV
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