Tamoxifen drug resistance related microRNA molecule MiR-200a and application thereof

A technology of mir-200a and tamoxifen, used in DNA/RNA fragments, recombinant DNA technology, determination/inspection of microorganisms, etc.

Inactive Publication Date: 2016-03-16
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
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Problems solved by technology

However, while affirming the therapeutic effect, it has to be admitted that the drug resistance of tumor cells is an important reason for the metastasis and recurrence of ER-positive breast cancer, and the drug resistance of tamoxifen is the main reason for limiting its clinical efficacy.

Method used

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  • Tamoxifen drug resistance related microRNA molecule MiR-200a and application thereof
  • Tamoxifen drug resistance related microRNA molecule MiR-200a and application thereof
  • Tamoxifen drug resistance related microRNA molecule MiR-200a and application thereof

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Embodiment Construction

[0018] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0019] Tamoxifen plays an important role in the treatment of breast cancer, but the emergence of drug resistance is the main reason for limiting its clinical efficacy. To clarify the biological function and mechanism of new microRNAs in breast cancer cell resistance to tamoxifen provides new biological target options for effectively improving the clinical efficacy of breast cancer.

[0020] The invention discloses a tumor drug-resistant microRNA molecule, which is MiR-200a, and its nucleotide sequence is CAUCUUACCGGACAGUGCUGGA.

[0021] The present invention also discloses the use of MiR-200a as a target for designing anti-breast cancer tamoxifen drug resistance, and the application of MiR-200a in the clinical diagnosis of breast cancer tamoxifen drug resistance, and according to this Target...

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Abstract

The invention discloses a tamoxifen drug resistance related microRNA molecule MiR-200a and application thereof, and belongs to the field of tumor biotherapy. The nucleotide sequence of the tamoxifen drug resistance related microRNA molecule MiR-200a disclosed by the invention is as shown in SEQ ID NO. 1. The MiR-200a, as a novel breast cancer tamoxifen drug-resistance marker, has the characteristics of low expression in ER positive breast cancer tamoxifen drug-resistance cells and high expression in ER positive breast cancer tamoxifen sensitive cells. Therefore, the invention provides a new target for designing breast cancer tamoxifen drug-resistance drugs, and subsequently, new drugs, directly corresponding to breast cancer tamoxifen drug resistance, are designed and developed. The MiR-200a disclosed by the invention has a biological function and an action mechanism of promoting breast cancer cell drug resistance; therefore, an effective way is provided for the effective reversal of breast cancer tamoxifen drug resistance and for the improvement of clinical chemotherapeutic effect on the breast cancer.

Description

technical field [0001] The invention belongs to the field of tumor biological treatment, and relates to a microRNA molecule MiR-200a related to tamoxifen drug resistance and application thereof. Background technique [0002] Breast cancer is one of the most common malignant tumors in women, and its high incidence seriously threatens women's health. Currently, tamoxifen-based endocrine therapy is of great significance for the efficacy of estrogen receptor (ER) positive breast cancer patients. [0003] Tamoxifen is currently the clinical first-line drug for the treatment of ER-positive breast cancer. The drug is a competitive antagonist of estradiol, which can attenuate the tumor proliferation mediated by estrogen receptor by competitively binding with estradiol to estrogen receptor. Metastasis-related signal transduction, so as to achieve the effect of tumor treatment. But while affirming the therapeutic effect, it has to be admitted that the drug resistance of tumor cells ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113C12Q1/68
CPCC12N15/113C12N2310/141C12Q1/6886C12Q2600/106C12Q2600/136C12Q2600/158C12Q2600/178
Inventor 张健李梦阳张媛陈苏宁
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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