Substituted xanthine compounds containing five-membered aromatic heterocycles and their preparation methods and uses

A compound, unsubstituted technology, applied in the field of medicine, can solve the problem of short half-life of active GLP-1
CN105646492BActive Publication Date: 2019-04-09INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Publication Date
2019-04-09

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Abstract

The present invention discloses a five-membered-aromatic-heterocycte-containing substituted xanthine compound and a preparation method and use thereof. More specifically, the present invention relates to a compound of formula (I) and stereoisomers and pharmaceutically acceptable salts thereof which are as described in specification. The present invention also relates to a pharmaceutical composition comprising the compound, use of the compound in the manufacture of drugs for treatment and / or prevention of diseases or disorders related to too high DPP-IV activity or DPP-IV overexpression, and a method for using the compound for treatment of the related diseases. The compound has efficient DPP-IV inhibitory activity.
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Description

technical field

[0001] The invention belongs to the technical field of medicine. It relates to substituted xanthine compounds containing five-membered aromatic heterocycles represented by general formula (I), pharmaceutically acceptable salts and isomers thereof, preparation of such compounds, pharmaceutical compositions containing them and the The application of the compound in preventing and / or treating diabetes, hyperlipidemia, obesity and metabolic syndrome, especially the application in inhibiting DPP-IV. Background technique

[0002] Diabetes Mellitus (DM) is a chronic metabolic disease with multiple etiologies, which seriously affects the health and quality of life of patients. At the end of 2013, there were approximately 382 million people with diabetes worldwide, and it is estimated that the number of people with diabetes will reach 592 million by 2035. According to statistics, the number of diabetics in China was about 98.4 million in 2013, ranking first in the w...

Claims

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