Peptide combinations and uses thereof in treating dust mite allergy

A peptide group, dust mite technology, applied in drug combination, allergic diseases, antigen/adjuvant combination components, etc.

Active Publication Date: 2016-08-10
ALK ABELLO SA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since this repertoire of class II HLA alleles varies from person to person and from one population to another, it is challenging to provide peptides that can be delivered to allergic subjects in any geographic region of the world. based immunotherapy rather than including large amounts of peptides in vaccines

Method used

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  • Peptide combinations and uses thereof in treating dust mite allergy
  • Peptide combinations and uses thereof in treating dust mite allergy
  • Peptide combinations and uses thereof in treating dust mite allergy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0384] Embodiment 1. A composition comprising at least 3 peptides, wherein said composition comprises at least 3 peptides selected from the following peptide groups:

[0385] Group 26: parent peptides of amino acid sequence SEQ ID NO: 82 (pep-110), 269 (pep-125), 70 (pep-099) or 253 (pep-012), or variants thereof;

[0386] Group 24: Parent peptides of amino acid sequence SEQ ID NO: 271 (pep-131), 67 (pep-096), 79 (pep-108), 256 (pep-031 ) or 270 (pep-126), or variants thereof body;

[0387] Group 14: the parent peptide of amino acid sequence SEQ ID NO: 268 (pep-130) or 22 (pep-054), or a variant thereof;

[0388] Group 1: the parent peptide of amino acid sequence SEQ ID NO: 90, or a variant thereof;

[0389] Group 2: the parent peptide of the amino acid sequence SEQ ID NO: 280, or a variant thereof;

[0390] Group 3: the parent peptide of amino acid sequence SEQ ID NO: 9 (pep-041), or a variant thereof;

[0391] Group 4: the parent peptide of amino acid sequence SEQ ID NO:...

Embodiment approach 2

[0411] Embodiment 2. The composition according to embodiment 1, wherein at least one peptide is selected from any of said peptide groups 1-17.

Embodiment approach 3

[0412] Embodiment 3. The composition according to any one of the preceding embodiments, wherein at least one peptide is selected from any of said peptide groups 18-26.

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PUM

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Abstract

The invention relates to combinations of peptides or variants thereof derived from a portion of an amino sequence of a house dust mite allergen, e.g. the allergens Der p 1, Der f 1, Der p 2 and / or Der f 2. Such peptides comprise at least one T cell epitope and a significant high number of patients in a worldwide population will have HLA alleles with the potential to bind the peptides of the peptide combinations. The invention also relates to the use of such peptide combinations in relieving an immune response caused by a dust mite.

Description

technical field [0001] The present invention relates to compositions of peptides derived from house dust mite allergens, methods of using such compositions for modulating immune responses, for treating allergic reactions in a subject and / or inducing or promoting immune tolerance in a subject acceptance, as well as diagnostic methods and kits. Background technique [0002] Allergies to dust mites affect people in most parts of the world. The most common dust mites are the European house dust mite (Dermatophagoides pteronyssinus) and the American house dust mite (Dermatophagoides farinae), which contain the major allergens Der p 1 / Der p 2 and Der f 1 / Der f 2, respectively. Other common dust mites are found in subtropical / tropical regions of the world such as Blomiatropicalis containing the major allergens allergens Blo t 1 and Blo t 2 and the major allergens allergens Eur m 1 and Eur m 2 The buried European mite (Euroglyphusmaynene). [0003] Currently, the treatment of dus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/35A61P37/08
CPCA61K39/35A61P37/08C07K14/43531A61K2039/555
Inventor C·伦德迦德L·H·克里斯坦森P·A·维岑A·赛特J·西德尼G·兰德
Owner ALK ABELLO SA
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