SYP-7017 synthesis method

A technology for chlorpyrifostrobin and sodium triclopyridine, which is applied in the field of synthesizing chlorpyrifostrobin, can solve the problems of inflammability and explosion, complicated separation process technology, restrictions and the like, and achieves the effects of reducing pollution and simplifying the technological process.

Active Publication Date: 2017-01-18
JIANGSU BAOLING CHEM
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Problems solved by technology

[0003] In the traditional synthesis process of Chlorazurin, toluene and dimethylformamide (DMF) are often used as solvents, both of which are toxic, flammable and explosive
Moreover, the low yield of the traditional process and the cumbersome separation process limit its industrial application to a certain extent.

Method used

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  • SYP-7017 synthesis method
  • SYP-7017 synthesis method

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Embodiment Construction

[0019] see figure 1 , the embodiment of the method for synthesizing Chlorazurin of the present invention comprises the following steps:

[0020] S100: mixing sodium 3,5,6-trichloropyridinate, alkane solvent, water and additives, and then adding methyl N-methoxy-N-(2-bromomethylphenyl)carbamate for reaction.

[0021] In an application scenario, the reaction bottle used in the embodiment of the present invention is equipped with a stirrer, a condenser, and a thermometer, and is placed in a constant temperature water bath. The pH of the reaction system was maintained at 9-10 by dropping NaOH solution with a mass fraction of 30%.

[0022] After the S200 reaction is completed, the oil phase is separated, and the solvent is removed from the alkanes to obtain the crude product of cloclostrobin.

[0023] During the reaction, through sampling analysis, when the content of methyl N-methoxy-N-(2-bromomethylphenyl)carbamate is lower than 0.2%, the reaction is considered complete.

[00...

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Abstract

The present invention discloses a SYP-7017 synthesis method. The method is as follows: mixing 3, 5, 6-trichloropyridin-2-ol sodium, an alkane solvent, water and additives, then adding N-methoxy-N-[2-(bromomethyl)phenyl] methyl carbamate for reaction; after the reaction is completed, separating an oil phase, and removing the alkane solvent to obtain a crude SYP-7017 product. By the above method, the technological process of the synthesis of the SYP-7017 can be simplified, the safety of the process is improved, and pollution to environment is reduced.

Description

technical field [0001] The invention relates to a method for forming a material, in particular to a method for synthesizing clostrostrobin. Background technique [0002] Clostristrobin is a new type of Strobilurin fungicide with broad-spectrum fungicidal activity, especially excellent in the control of the most important crop disease - powdery mildew, and it is safe to crops and the environment. [0003] In the traditional synthesis process of Chlorazurin, toluene and dimethylformamide (DMF) are often used as solvents, both of which are toxic, flammable and explosive. Moreover, the low yield of the traditional process and the cumbersome separation process limit its industrial application to a certain extent. Contents of the invention [0004] The main technical problem to be solved by the present invention is to provide a method for synthesizing chlorazoxystrobin, which can simplify the process, improve the safety of the process, and reduce environmental pollution at the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D213/64
CPCC07D213/64
Inventor 虞卉俞建平尤学芬金明华缪俊
Owner JIANGSU BAOLING CHEM
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