4 results about "Methyl carbazate" patented technology

The invention discloses a preparation method of a carptorelin intermediate based on catalytic oxidation of yeast alcohol dehydrogenase, which comprises the following operation steps of: generating an intermediate product 1 from N-Boc-4-piperidinol by adopting a method of catalytic oxidation of yeast alcohol dehydrogenase oxidase, purifying, adding semicarbazide, and reacting to obtain the carptorelin intermediate. The preparation method comprises the following steps: reacting at least one of tert-butyloxycarboryl hydrazine or methyl carbazate with alkali to generate an intermediate product 2, adding DMF-DMA to react with alkali to generate an intermediate product 3, adding benzyl bromide to react with basic salt to generate an intermediate product 4, and adding acid to react to generate the carprorelin intermediate. According to the method, a brand new synthesis route is used, the semicarbazide which is low in price and easy to obtain is adopted in the new process route, hydrazine hydrate which seriously pollutes a water body is prevented from being used, highly toxic methylhydrazine is prevented from being used, a shrinkage process and a micro-channel continuous flow process can be adopted in the synthesis steps, and the method is simple in process, high in yield, good in safety and high in product quality.

The invention provides a preparation method of benzyl carbazate, and belongs to the technical field of organic synthesis. The method comprises the following steps: reacting methyl carbazate with benzyl alcohol under the action of a catalyst to prepare benzyl carbazate; the catalyst is a metal organic framework immobilized lipase composite catalyst. The prepared catalyst can greatly improve the reaction activity and increase the yield of products under the synergistic effect of multi-metal coordinated catalysis and organic alkali and lipase, meanwhile, the reaction condition is mild, the preparation method is simple, no pollutant is generated in the reaction, and the catalyst is more environmentally friendly and efficient.

The invention relates to the technical field of organic synthesis, and in particular to a method for synthesizing benzyl hydrazinecarboxylate, a pesticide intermediate. The method comprises the following steps: uniformly mixing methyl hydrazinecarboxylate, benzyl alcohol and a catalyst, stirring and heating to 70-90°C, carrying out a heat preservation reaction until no fraction is distilled out, then heating to 110-120°C and carrying out a heat preservation reaction for 1-10 hours, cooling a reaction solution to 40-80°C, removing the catalyst while hot, and then performing a reduced pressure distillation of a filtrate to obtain a crude product, and purifying the crude product to obtain a finished benzyl hydrazinecarboxylate product. The invention adopts a LnFeNi ternary hydrotalcite-based composite oxide with high catalytic activity as a catalyst, and the catalyst has a specific composition, a special structural morphology and a high specific surface area, and can reduce the reaction temperature to below 120°C, and still has a high yield and product purity.

This invention provides a method for synthesizing biphenylhydrazine, relating to the field of pesticide and intermediate synthesis technology. The method includes: (1) reacting 4-methoxybiphenyl with a brominating agent to obtain 3-bromo-4-methoxybiphenyl; (2) in the presence of a copper catalyst, a ligand, and a base, coupling the 3-bromo-4-methoxybiphenyl with methyl hydrazine formate to obtain methyl 3-(4-methoxybiphenyl-3-yl)hydrazine formate; and (3) subjecting the methyl 3-(4-methoxybiphenyl-3-yl)hydrazine formate to an isopropyl ester transesterification reaction to obtain the biphenylhydrazine. This invention avoids the use of high-risk reagents (such as nitrating agents) and expensive precious metal catalysts throughout the reaction process, is simple to operate, has a high overall yield, and good atom economy; the overall process is safe and efficient, suitable for industrial application.