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Improved Ultrasonic Surgical System

An ultrasonic knife and hand-held technology, applied in the field of improved ultrasonic surgical operation system, can solve the problems of safety, small vibration amplitude of ultrasonic knife, etc.

Active Publication Date: 2017-07-28
上海岐华医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the vibration amplitude of the ultrasonic knife is very small, usually 50-100 μm, the surface of the end effector (21) is usually treated with anti-adhesive treatment. Composite ceramic materials etc. as the surface (for example, refer to Chinese Patent Application No. 200880118493), especially commercially available The ultrasonic knife is also famous for its anti-sticking performance. It is difficult to use an aqueous solution to coat biologically active substances such as water-soluble proteins or active peptides. However, coating with a special solvent with high adhesion to this type of surface will cause safety. Sexual problems, so there is no report on the corresponding coating technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 Improved bFGF variant and its preparation

[0045] According to the adsorption characteristics of amino acid side chain groups and the active site of basic fibroblast growth factor we studied, a bFGF variant with the amino acid sequence shown in SEQ ID NO: 1 and its multinuclear expression optimized in Escherichia coli were designed. The nucleotide sequence (see SEQ ID NO: 2) was synthesized by Sangon Bioengineering (Shanghai) Co., Ltd. and cloned into the pET28a+ plasmid. After correct sequencing, it was transformed into E. coli BL21 (DE3) cells to obtain a prokaryotic expression strain. Also entrusted to synthesize a prokaryotic expression strain expressing wild-type bFGF (see GenBank accession number AAA52533.1 for the amino acid sequence) as a positive control.

[0046] Spread the commissioned prokaryotic expression strain on LB plates and rejuvenate overnight at 37°C, pick a single colony and inoculate in 150mL LB liquid medium, shake and culture at 37...

Embodiment 2

[0048] Embodiment 2 Improved ultrasonic scalpel and its manufacture

[0049] Such as figure 1 As shown, the ultrasonic scalpel system includes a cutter head part 1, a host machine 2 and a cable 3 connecting the two, wherein the cutter head part 1 includes an end effector 21 located at the front of the cutter head body 22, a cutter head body 22 And be positioned at the handle 23 of cutter head main body 22 bottoms, be provided with ultrasonic transducer in the cutter head main body 22, be provided with switchgear on the handle 23, and prior art (as, Johnson & Johnson ACE+ultrasonic scalpel) is different, that is, the improvement of the present invention is: 1. The switch device includes a pressing piece 231 and a spring 232 connecting the pressing piece and the handle 23. The spring is located outside the handle 23 and is convenient for dismounting. This can replace springs with different elastic coefficients so as to be suitable for different medical workers' feel strength, ...

Embodiment 3

[0053] The bFGF release test of the improved ultrasonic knife of embodiment 3

[0054] Immerse the end effector 21 of the ultrasonic knife head part 1 coated according to Example 2 into a test tube containing 2 mL of physiological saline, start the ultrasonic wave for 3 seconds, then let it stand for 5 seconds, take out the ultrasonic knife and pass the MTT method (See Example 1) The proliferative activity of the eluate in each test tube was detected, and the results are shown in Table 1.

[0055] Table 1 The light absorption value of 3T3 cell culture medium

[0056] group Absorbance negative control Corrected to 0.00 Control 1 0.01 Control 2 0.05 this invention 0.23

[0057] The results showed that active bFGF was hardly coated and released from the end effector 21 without the use of the bFGF variants of the present invention, or without the use of a saturated calcium carbonate solution containing mannose, where wild-type The poor co...

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Abstract

The invention provides an improved ultrasonic surgical operation system. The improved ultrasonic surgical operation system is characterized in that a water-soluble coating for promoting the healing of a wound or the like is arranged on the surface of an end part executor of an ultrasonic knife; a switch device on a handheld handle is improved. In addition, the invention also relates to the manufacturing, the application and the like of the ultrasonic knife, and the manufacturing of intermediate agents, including a coating liquid for promoting the healing of the wound.

Description

technical field [0001] The present invention belongs to the combined field of medical equipment and protein medicine, in particular, the present invention relates to an improved ultrasonic surgical operation system, the main improvement of which is that the surface of the end effector of the ultrasonic knife is provided with a water-soluble coating such as promoting wound healing, and Improved switchgear on handle. In addition, the present invention also relates to the manufacture and application of the ultrasonic knife, especially the intermediate reagents for the manufacture of coating liquids for promoting wound healing and pre-coating liquids that do not contain biologically active substances. [0002] Background of the invention [0003] Ultrasonic surgical systems utilize ultrasonic transducers to generate mechanical vibrations at ultrasonic frequencies to perform surgical procedures, especially minimally invasive surgical procedures. At present, the most mature ultras...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B17/32A61L31/16A61L31/10A61L31/08C07K14/50C12N15/12
CPCA61B17/320068A61B2017/00831A61L31/08A61L31/088A61L31/10A61L31/16A61L2300/252A61L2300/412A61L2300/606A61L2300/802C07K14/503
Inventor 王卿任任
Owner 上海岐华医疗科技有限公司
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