Sprague-Dawley rat-based suicide relevant behavior animal model construction method

Abstract

The invention discloses a Sprague-Dawley rat-based suicide relevant behavior animal model construction method, and belongs to the field of animal model construction. The method comprises the step that learned helplessness rats and non-learned helplessness rats are screened out from a learned helplessness model, and accept social defeat stimulation overlaid chronic unpredictable mild stimulation in four weeks. The behavioristics analysis finds that the rat model shows that the rats have typical suicide relevant behaviors after the four-weak stress, and the rats have the typical suicide characteristics such as invasion, impulsion, irritability and desperation. Successful construction of the model provides a novel research carrier for a research mechanism for researching suicide relevant behaviors.

Description

technical field

[0001] The invention belongs to the field of animal model construction, in particular to a method for constructing an animal model of suicide-related behavior on SD rats through chronic stress. Background technique

[0002] Suicide is a social problem that seriously endangers public health and plays an important role in the global cause of death, which brings heavy mental and economic burdens to families and society. According to the WHO report, more than 80,000 people die by suicide every year worldwide, and more people have suicidal thoughts and behaviors. Therefore, strengthening the prevention and control of suicide has become a major public health problem that needs to be solved urgently. But so far, the pathogenesis of suicide is unclear. Current research on suicide-related mechanisms mainly relies on human tissues. However, human tissue is difficult to obtain, which largely limits suicide-related research. In the prior art, people have not yet been...

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