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Construction method of animal model of suicide-related behavior based on sprague-dawley rats

A technology of animal models and construction methods, applied in animal husbandry and other fields, can solve problems such as difficulty in obtaining human tissue and limiting suicide-related research

Active Publication Date: 2019-05-28
CHONGQING MEDICAL UNIVERSITY
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Problems solved by technology

However, human tissue is difficult to obtain, which largely limits suicide-related research
In the prior art, people have not yet been able to establish an effective suicide animal model for exploring suicide-related behaviors and potential drug treatment targets

Method used

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  • Construction method of animal model of suicide-related behavior based on sprague-dawley rats
  • Construction method of animal model of suicide-related behavior based on sprague-dawley rats
  • Construction method of animal model of suicide-related behavior based on sprague-dawley rats

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Experimental program
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Embodiment Construction

[0014] The specific experimental process of the present invention and the analysis of the experimental results are further described in detail below. See the experimental procedure figure 1 .

[0015] Experimental animals: male Sprague-Dawley (SD) rats with a body weight of 200-250 grams, 8-10 weeks old, male Long-Evans (LE) rats with a body weight of 200-250 grams, 3-4 months old, 350-400 grams, and 250- 300 g of female LE rats.

[0016] Main reagents: edible sucrose, 70% alcohol.

[0017] Main instruments: YLS-17B dark avoidance shuttle tester, transparent glass barrel, open field box, plastic bottle, high-definition camera, small animal behavior video collection and analysis system.

[0018] experiment procedure

[0019] (1) Use learned helplessness model to screen out learned helpless rats and non-learned helpless rats from SD rats.

[0020] Environmental adaptation of experimental animals: Before the start of the experiment, SD rats were reared in a single cage and a...

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Abstract

The invention discloses a Sprague-Dawley rat-based suicide relevant behavior animal model construction method, and belongs to the field of animal model construction. The method comprises the step that learned helplessness rats and non-learned helplessness rats are screened out from a learned helplessness model, and accept social defeat stimulation overlaid chronic unpredictable mild stimulation in four weeks. The behavioristics analysis finds that the rat model shows that the rats have typical suicide relevant behaviors after the four-weak stress, and the rats have the typical suicide characteristics such as invasion, impulsion, irritability and desperation. Successful construction of the model provides a novel research carrier for a research mechanism for researching suicide relevant behaviors.

Description

technical field [0001] The invention belongs to the field of animal model construction, in particular to a method for constructing an animal model of suicide-related behavior on SD rats through chronic stress. Background technique [0002] Suicide is a social problem that seriously endangers public health and plays an important role in the global cause of death, which brings heavy mental and economic burdens to families and society. According to the WHO report, more than 80,000 people die by suicide every year worldwide, and more people have suicidal thoughts and behaviors. Therefore, strengthening the prevention and control of suicide has become a major public health problem that needs to be solved urgently. But so far, the pathogenesis of suicide is unclear. Current research on suicide-related mechanisms mainly relies on human tissues. However, human tissue is difficult to obtain, which largely limits suicide-related research. In the prior art, people have not yet been...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01K67/02
CPCA01K67/02A01K2267/035
Inventor 谢鹏周新雨蒲俊材刘兰香张玉清杨力凝袁帅张涵萍谢雄飞
Owner CHONGQING MEDICAL UNIVERSITY
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