Application of geraniol to preparation of antidepressants

A geraniol and anti-depressant technology, which is applied in the field of medicine, can solve the problems of many side effects, poor drug tolerance, and easy relapse, and achieve the effect of increasing sugar water preference, shortening immobility time, and significantly resisting experimental depression in mice Effect

Inactive Publication Date: 2014-08-13
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these traditional antidepressants may take effect only 2 to 4 weeks after medication, and they only work for about 70% of patients. At the same time, there are many side effects, poor patient tolerance to drugs, and easy relapse.

Method used

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  • Application of geraniol to preparation of antidepressants
  • Application of geraniol to preparation of antidepressants
  • Application of geraniol to preparation of antidepressants

Examples

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Embodiment 1

[0013] Example 1 Influence test of geraniol described in the invention on chronic stress depression model mice

[0014] 1 Experimental method

[0015] 1.1 Establishment of chronic unpredictable mild stimulus depression model

[0016] Establish a chronic mild unpredictable stress model. Among them, the chronic mild stimulation includes: (1) tail suspension for 10 minutes, (2) shaking the mouse cage for 10 minutes, (3) noise (unFM radio) for 3 hours, (4) cage tilt (about 30°) for 8 hours or overnight, (5) wet bedding (150ml water) for 8 hours or overnight, (6) foreign matter for 8 hours or overnight, (7) lighting overnight, (8) tail clamping for 5 minutes, (9) restraint for 10 minutes, ( 10) fasting for 8 hours or overnight, (11) fasting for 8 hours or overnight.

[0017] The model group, fluoxetine group, and geraniol high-dose and low-dose groups were treated with the above-mentioned chronic mild stress for 3 weeks. The above two different stresses were used every day, and...

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Abstract

The invention relates to the field of medicine, and in particular relates to an application of geraniol to preparation of antidepressants. As proved by the results of mouse chronic unpredictable mild stimulation depression model weight appearance test, sucrose preference test, open field test, forced swimming test and the like, the geraniol has remarkable anti-depression activity, and can be used for preparing antidepressants.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of geraniol in the preparation of antidepressant drugs. Background technique [0002] Geraniol is a colorless to yellow oily liquid with a mild and sweet rose scent and a bitter taste. Soluble in organic solvents, hardly soluble in water. CAS number: 106-24-1, structural formula: [0003] [0004] Geraniol is a natural plant-derived alcohol, which exists in volatile oils such as citronella, geranium, vanilla, rose, lavender, nutmeg, lemon, orange, etc. It is widely used in flavors, food, daily products and other fields. Modern pharmacological studies have shown that geraniol has antibacterial, antitumor and immune regulation effects. For example, geraniol can inhibit the proliferation of liver tumor cells and melanoma cells, and inhibit the growth and metastasis of colon tumor cells; geraniol has strong antibacterial effects on Aspergillus flavus, Aspergillus niger a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61P25/24
Inventor 傅强马世平邓雪阳薛劲松马占强李虹燕贺雅婷
Owner CHINA PHARM UNIV
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