A tumor marker and combined detection method thereof in blood

A technology for joint detection of tumor markers, applied in the field of joint detection of tumor markers and their detection in blood, can solve the problems of high specificity, insufficient organ specificity, insufficient sensitivity, and insufficient accuracy

Inactive Publication Date: 2017-04-26
杨泳
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Problems solved by technology

[0004] The purpose of the present invention is to provide a tumor marker and its combined detection method in blood, aiming to solve the problem that most markers with high sensitivity have low specificity, while those with high specificity have low sensitivity and low sensitivity. The assessment of tumor markers may not be sensitive enough, the accuracy is not high enough, and the organ specificity is not strong enough

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  • A tumor marker and combined detection method thereof in blood
  • A tumor marker and combined detection method thereof in blood
  • A tumor marker and combined detection method thereof in blood

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[0037] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0038] Whether MFG-E8 of the present invention has high expression in breast invasive ductal carcinoma; whether there is any difference in expression in cancer tissues of different tissue grades or different infiltration characteristics; whether it is correlated with other breast cancer immunohistochemical indicators; thus confirming MFG -Whether E8 can be a new indicator for evaluating the prognosis of breast cancer.

[0039] Immunohistochemical methods were used to detect the expression levels of MFG-E8 and ER in 54 breast cancer tissues and paracancerous tissues, and their correlation with the occurrence, development, in...

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Abstract

The invention discloses a tumor marker and a combined detection method thereof in blood. The tumor marker comprises MFG-E8, CA153 and CEA. The combined detection method comprises the steps of the serum level detection of MFG-E8, CA153 and CEA, the setting of critical value, statistical analysis, comparison of three indexes detection of the serum level of MFG-E8, CA153 and CEA and comparison of positive rate, and combined detection of the serum level of MFG-E8, CA153 and CEA. Ar present most marker has a high sensitivity and low selectivity, the marker with a high selectivity has a low sensitivity, therefore the present markers cannot be used for an early diagnosis and differential diagnosis of tumor in an optimal manner. The tumor marker and the combined detection method thereof in blood compensate the deficiency that a single tumor marker suffers from either insufficient sensitivity or insufficient selectivity in a clinical test. The selection of MFG-E8, CA153 and CEA for the combined detection can improve the sensitivity, selectivity and accuracy of the detection.

Description

technical field [0001] The invention belongs to the technical field of genetic engineering, and in particular relates to a tumor marker and a combined detection method in blood. Background technique [0002] Breast cancer is one of the most common malignant tumors in women, which seriously threatens women's health, and its incidence is increasing year by year. The survival rate of breast cancer patients is closely related to the stage of cancer. Data show that the 5-year and 10-year survival rates of stage I patients are 90.9% and 83.7% respectively; stage II are 78.0% and 65.8%; stage III are 53.5% and 43.0% respectively, and patients with distant metastasis of breast cancer (IV Stage) 5-year survival rate (23%) was significantly lower than stage III breast cancer patients (79%) and I-II breast cancer patients (97%). Therefore, early diagnosis and detection are the key to improving the survival rate and reducing mortality of breast cancer patients. The early diagnosis of...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N27/26
CPCG01N27/26G01N33/57415G01N33/57488
Inventor 杨泳张家衡李杰宝宋旗
Owner 杨泳
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