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Application of tumor-specific transplantation antigen protein tsta3 in the preparation of diagnostic reagents for esophageal squamous cell carcinoma

A technology of tumor-specific transplantation antigen, which is applied in the field of preparation of diagnostic reagents for esophageal squamous cell carcinoma of the tumor-specific transplantation antigen protein TSTA3, which can solve the problems of few molecular targets and different evaluation criteria for diagnosis and prognosis information, and achieve rapid prediction The effect of the method

Active Publication Date: 2018-07-13
SHANXI MEDICAL UNIV
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Problems solved by technology

[0010] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a use of tumor-specific transplantation antigen protein TSTA3 in the preparation of diagnostic reagents for esophageal squamous cell carcinoma, which solves the problem of patients with esophageal squamous cell carcinoma Very few molecular targets for diagnostic and prognostic information, technical issues with mixed criteria

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  • Application of tumor-specific transplantation antigen protein tsta3 in the preparation of diagnostic reagents for esophageal squamous cell carcinoma
  • Application of tumor-specific transplantation antigen protein tsta3 in the preparation of diagnostic reagents for esophageal squamous cell carcinoma
  • Application of tumor-specific transplantation antigen protein tsta3 in the preparation of diagnostic reagents for esophageal squamous cell carcinoma

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Embodiment 1

[0028] Example 1: A method for assisting the diagnosis and evaluating the prognosis of patients with esophageal squamous cell carcinoma through the expression of tumor-specific transplantation antigen protein TSTA3, an immunological index of esophageal squamous cell carcinoma. "(Published by People's Health Publishing House). Tissue chips were incubated with 1:400 TSTA3 antibody (anti-rabbit monoclonal antibody, ab190002, Abcam) at 4°C for 14 hours, and then processed with DAB detection kit (Maixin, Fuzhou, China). Images were taken at ×100 after mounting with hematoxylin blue staining. Using automatic digital pathology scanning equipment (Aperio, America) and image analysis software to analyze the staining intensity in the cytoplasm of tumor tissue and normal epithelial tissue cells to reflect the expression of TSTA3 protein.

[0029] Specifically include the following steps:

[0030] (1) Paraffin-embedded 104 surgically resected primary cancers and 60 matched paracancerous...

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Abstract

The invention belongs to the technical field of biological medicine and provides application of a tumor-specific transplantation antigen protein TSTA3 in preparation of an esophageal squamous carcinoma diagnosis reagent. The technical problem that an esophageal squamous carcinoma patient has very few molecular targets of diagnosis and prognosis information in the prior art and judgment criterions are different is solved by adopting the application. The relation with the diagnosis and prognosis of the patient is determined by conducting immune scoring on the TSTA3 protein expression situation and through the expression quantity of the protein TSTA3 and is used for assisting diagnosis and prognosis evaluation of the esophageal squamous carcinoma patient. The diagnosis and prognosis evaluation of the esophageal squamous carcinoma patient are assisted through the expression quantity of the immunological index protein TSTA3, and an accurate and rapid prediction method is provided for solving the problem that no means for diagnosis and prognosis evaluation of the esophageal squamous carcinoma patient is provided.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the use of a tumor-specific transplantation antigen protein TSTA3 in preparing diagnostic reagents for esophageal squamous cell carcinoma. Background technique [0002] Esophageal cancer is one of the most common malignant tumors in the world. my country is the country with the highest morbidity and mortality rate of esophageal cancer, with 478,000 new cases and 375,000 deaths every year. third and fourth. The incidence of esophageal cancer in my country is mainly concentrated in several high-incidence areas, among which the Taihang Mountains at the junction of Henan, Shanxi, and Hebei have the highest incidence. Different from western countries, 90% of the histological types of esophageal cancer in my country are squamous cell carcinoma, and most patients are already in the middle and late stages when they are diagnosed, the disease progresses rapidly, the progno...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68G01N33/574
CPCG01N33/574G01N33/6803G01N2800/50
Inventor 崔永萍孔鹏洲杨洁阎婷杨健成晓龙翟元芳程彩霞马燕春钱钰
Owner SHANXI MEDICAL UNIV
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