A kind of traditional Chinese medicine for treating venomous snake bite and preparation method thereof

A technology for poisonous snake bites and traditional Chinese medicine, which is applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Increase mortality and other issues, to achieve good results

Active Publication Date: 2020-10-16
AFFILIATED HOSPITAL OF JIANGXI UNIV OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recently, it has been reported abroad that the death rate from snakebite has increased, mainly because the serum has a good curative effect when used within 2 hours after the injury, and it can only neutralize free snake venom. When the snake venom combines with tissues and organs to cause damage, it is difficult to be effective.
In addition, factors such as few serum dosage forms, strong specificity, inconvenient storage, unstable biological potency, and easy allergies lead to great limitations in its use.
Domestic literature reports that traditional Chinese medicine has a good effect on the treatment of venomous snake bites, but there is a lack of strict evidence-based medicine and animal experiment evidence, and the repeatability and operability are not strong

Method used

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  • A kind of traditional Chinese medicine for treating venomous snake bite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] A kind of Chinese medicine for the treatment of venomous snake bites of the present embodiment, wherein the composition ratio of medicinal materials:

[0014] Aescin 30g, Lobelia 30g, Realgar 8g, Wulingzhi 8g, Sappan 8g, Chuanxiong 8g, Phellodendron 10g, Wild chrysanthemum 10g, Pueraria 10g, Dry alum 8g, Star anise 10g, White vinegar 200ml.

[0015] The above-mentioned Chinese medicine preparation method for the treatment of poisonous snake bites is carried out according to the following steps:

[0016] Aescin 30g, lobelia 30g, realgar 8g, wulingzhi 8g, sumac 8g, chuanxiong 8g, Phellodendron 10g, wild chrysanthemum 10g, kudzu root 10g, dry alum 8g, star anise lotus 10g crushed and mixed, placed in In the container, add vinegar while stirring slowly until it becomes a paste ointment. It can be applied externally around the wound and on the swollen and purple place.

example 2

[0018] 1. Clinical data

[0019] 1.1 General information: 90 patients, aged 1-72 years, with an average age of 43 years. Bite site: 46 cases of lower limbs, 34 cases of upper limbs, 10 cases of head and neck.

[0020] 1.2 Treatment methods

[0021] 1) Wound treatment: local routine debridement and detoxification, keep moist, drainage.

[0022] 2) External application: external application of the drug of Example 1 around the wound and on the swollen and purple place, three times a day.

[0023] 1.3 Curative effect standard

[0024] The symptoms of systemic poisoning disappeared, the swelling of the affected limb subsided, the ecchymosis subsided, and the analgesic effect was good.

[0025] 2. Results

[0026] The cure rate of this group of 90 patients using this therapy is 100%. For mild patients, the average swelling time was 4 hours, the average ecchymosis time was 9 hours, and the average pain relief time was 8 hours. The average time for moderate swelling was 11 hour...

Embodiment 3

[0030] Embodiment 3: the medicine that following each group (A-K) is made compares with the Chinese medicine for the treatment of venomous snake bite that the embodiment 1 makes, and the average detumescence time is longer than embodiment 1 at least more than 30%, and the ecchymosis average disappearance time It is at least 42% longer than Example 1, and the average analgesic time is at least 48% longer than that of Example 1. The medicines of each group (A-K) are as follows:

[0031] A. After crushing 140g of aescin, put it in a container, add 200ml of white vinegar, and stir slowly until it becomes a pasty ointment. It can be applied externally around the wound and on the swollen and purple place.

[0032] B. After crushing 140g of lobelia, put it in a container, add 200ml of white vinegar, and stir slowly until it becomes a pasty ointment. It can be applied externally around the wound and on the swollen and purple place.

[0033] C. After crushing 140g of realgar, put it ...

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Abstract

The invention discloses traditional Chinese medicine for treating poisonous snake bit. The traditional Chinese medicine is prepared from herbal materials: 30 to 40g of rhizome paris polyphyllae, 30 to 40g of herba lobeliae chinensis, 8 to 15g of realgar, 8 to 15g of trogopterus dung, 8 to 15g of lignum sappan, 8 to 15g of rhizoma chuanxiong, 10 to 20g of cortex phellodendri, 10 to 20g of flos chrysanthemi indici, 10 to 20g of radix puerariae, 8 to 15g of dried alum, 10 to 20g of herba dysosmae versipellis and white vinegar. All herbs are combined to collectively play efficacies for removing and resisting toxicity, clearing away the internal heat, expelling the wind, stimulating the blood circulation, removing the stasis, eliminating the inflammation and alleviating the pain. When the traditional Chinese medicine is used for treating the inflammation, pain and ecchymosis caused by the poisonous snake bite, and the care rate is high.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating venomous snake bites. Background technique [0002] Venomous snake bite is a common disastrous disease that seriously affects people's life and health. There are about 5 million snakebite patients in the world every year, with an annual death toll of 50,000, and about 400,000 amputees caused by snakebite. More than 100,000 people are bitten by poisonous snakes in my country every year, and the number is increasing year by year. After being bitten by a venomous snake, the snake venom spreads and is absorbed locally, resulting in severe systemic symptoms. In mild cases, dysfunction occurs. [0003] Although the application of antivenom has reduced the mortality rate of patients, the rate of limb disability has not decreased. Recently, it has been reported that the death rate of snakebite has increased in foreign countries, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61K36/896A61K9/06A61P39/02A61P17/02A61P29/00A61K33/06A61K33/36A61K35/24
CPCA61K9/0014A61K9/06A61K33/06A61K33/36A61K35/24A61K36/11A61K36/236A61K36/287A61K36/29A61K36/34A61K36/48A61K36/488A61K36/756A61K36/896A61K47/46A61K2300/00
Inventor 喻文球王万春严张仁李燕芳朱卫丰陈丽华管咏梅吴璐金晨
Owner AFFILIATED HOSPITAL OF JIANGXI UNIV OF TCM
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