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Application of Compound Xueshuantong Preparation in Preparation of Drugs for Treating Kidney Damage Caused by Hypertension

A technology for compound Xueshuantong and high blood pressure, which is applied in the directions of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve the effect of expanding the scope of medicinal use

Active Publication Date: 2021-02-23
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the clinical treatment of cardiovascular and cerebrovascular diseases, antihypertensive and lipid-lowering drugs are often combined and taken for a long time, which can easily cause excessive burden on the kidneys

Method used

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  • Application of Compound Xueshuantong Preparation in Preparation of Drugs for Treating Kidney Damage Caused by Hypertension
  • Application of Compound Xueshuantong Preparation in Preparation of Drugs for Treating Kidney Damage Caused by Hypertension
  • Application of Compound Xueshuantong Preparation in Preparation of Drugs for Treating Kidney Damage Caused by Hypertension

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Experimental program
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Embodiment Construction

[0011] The present invention will be further described below in conjunction with specific examples, but the present invention is not limited thereto.

[0012] 1. Materials

[0013] (1) Animals: 50 SPF (specific-pathogen free) male SHR (spontaneouslyhypertensive rats) rats, weighing 180-200g; 10 SPF male WKY (Wistar Kyoto) rats, weighing 180-220g; Provided by Tonglihua Experimental Animal Technology Co., Ltd. They were raised in SPF grade animal rooms, the temperature of the observation room was 20°C-23°C, the relative humidity was 50%-65%, and the light was 12 hours a day.

[0014] (2) Instruments: Roche P 800 automatic biochemical analyzer (Roche, MODULAR P800), ultra-low temperature refrigerator (Haier, BCD-568W), low-temperature centrifuge (Eppendorf, 5430R), one hundred thousandth electronic balance (Sartorius, BP211D ), a vortex shaker (Scientific Industries Vortex-Genie 2).

[0015] (3) Reagents: 60% fat heat energy rodent common pellet feed, epinephrine hydrochloride...

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Abstract

The invention discloses the application of compound Xueshuantong preparation in the preparation of medicine for treating kidney damage caused by hypertension. Including the application in the preparation of drugs for treating renal dysfunction caused by hypertension and drugs for renal renin-angiotensin-aldosterone system disorders. Compared with the prior art, the present invention discloses for the first time multiple new uses of the compound Xueshuantong preparation in the preparation of medicines for treating kidney damage caused by hypertension. The medicinal scope of compound Xueshuantong preparation has been expanded.

Description

technical field [0001] The invention relates to multiple new applications of the compound Xueshuantong preparation. Especially the application in medicine for treating kidney damage caused by high blood pressure. Background technique [0002] Hypertension is one of the important risk factors for cardiovascular and cerebrovascular diseases. At present, there are 330 million hypertensive patients in China, accounting for 30% of the global patients. With the development of hypertension, the main target organs of damage include kidney, heart, brain, etc. Among them, the kidney plays an important role in the regulation of blood volume, electrolyte balance, and renin-angiotensin-aldosterone system, and its damage is related to hypertension. A vicious circle will be formed between them, and finally multiple organ dysfunction. In addition, in the clinical treatment of cardiovascular and cerebrovascular diseases, antihypertensive and lipid-lowering drugs are often combined and take...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/808A61K9/48A61P13/12A61P9/12
Inventor 姚宏亮刘宏苏薇薇张伟健严曾豪李沛波吴忠王永刚彭维
Owner SUN YAT SEN UNIV
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