71 results about "Two kidney" patented technology

A method for treating congestive heart failure (CHF) has been developed that restores kidney renal functions by artificial vasodilation of at least one kidney. A vasodilator drug is locally delivered to the kidney via a kidney perfusion catheter. The drug can be mixed with the patient's blood, saline or other suitable solvent and the mixture directly applied to the kidney through the catheter. The restoration of kidney function assists the heart by removing excess fluid, urine and toxin from the patient, and by normalizing the patient's renin-angiotensin system and other neurohormonal substances. The method is applicable to treat chronic and acute CHF.

Methods of detecting or predicting the onset or magnitude of kidney diseases such as acute kidney disease (AKI), previously called acute renal failure (ARF), are provided. In various aspects, methods and kits are provided to detect specific urinary proteins associated with AKI diagnosis or prognosis such as, e.g., angiotensinogen.

It is an object of the present invention to provide a combination of a functional assessment of renal function together with biomarker results in order to improve assessment of patient at risk of or having, an acute kidney injury. A loop diuretic such as furosemide inhibits luminal active chloride transport throughout the thick ascending limb of Henle, thereby preventing sodium reabsorption and resulting in natriuresis and increased urine flow. Loop diuretic-induced increases in urine output might be a method to assess the integrity of the renal tubular function in the setting of early AKI, and so a kidney's response, or lack thereof, to a diuretic challenge as a clinical assessment of tubular function can identify patients with severe tubular injury before it is clinically apparent (e.g. a rise in creatinine).

The present invention relates to a mechanical perfusion system for preservation of both isolated kidneys. The system comprises: (1) a perfusion liquid temperature control groove for holding a perfusion liquid; (2) two sets of isolated kidney preservation grooves for holding isolated kidneys; (3) pipelines connected between the perfusion liquid temperature control groove and the isolated kidney preservation grooves and used for conveying the perfusion liquid to the isolated kidneys; (4) a pressure detection module for detecting the pressures of the pipelines; (5) a flow rate detection module for detecting the flow rates of the pipelines; (6) a gas bubble detection module for detecting the gas bubbles of the pipelines; (7) an electromagnetic valve module for controlling the on-off of a liquid path; (8) a sampling module for extracting the perfusion liquid; (9) a control module for controlling a peristaltic pump and the electromagnetic valve module; and (10) a display module for displaying the pressures and the flow rates of the pipelines, and the resistance coefficient of the kidney organ.

Processes of localizing target papillas of renal anatomy involve advancing a ureteroscope to a target calyx of a kidney of a patient through at least a portion of a urinary tract of the patient, determining a positional offset between one or more position sensors associated with the ureteroscope and a target papilla of the kidney that is at least partially exposed within the target calyx, and determining a percutaneous access target based at least in part on one or more of a present position of the one or more position sensors and the offset.

The invention discloses a ureter ligation induced non-human primate animal renal fibrosis model building method and application. The specific technical scheme includes that an experimental monkey is anaesthetized by anesthetics, surgical anesthesia is maintained, the abdomen of the experimental monkey is cut apart along a medioventral line after disinfection, an abdominal cavity is opened, an operation field is exposed, a unilateral ureter at a unilateral renal lower edge is ligated twice by a surgical silk thread and completely blocked, another kidney is not ligated and serves as a self-body for comparison, a wound is stitched in a layered manner after a surgical incision is disinfected, renal fibrosis indexes are measured by biological samples at different time points after ligation, or a left kidney and a right kidney are taken down and fixed in neutral buffered formalin, and formalin fixed kidney samples are subjected to tissue section and pathological examination. An animal model has application values which cannot be realized by an existing rodent and rabbit animal model, and the non-human primate animal model built by the method has wide application in related fields of fibrosis.

The invention relates to a method to prevent contrast-induced nephropathy during an imaging procedure. The method includes steps of positioning balloon catheters in a patient's renal arteries and renal veins and inflating the balloons of each catheter to block the flow of contrast media into the patient's kidneys.

The invention discloses a distraction fixator for a kidney transplantation operation, and relates to the field of kidney transplantation operations. The distraction fixator for the kidney transplantation operation comprises a bed body, a supporting and positioning base, a lifting supporting mechanism and a distraction fixator structure, the bottom of the bed body is fixedly connected with two sets of supporting blocks, the two sets of supporting blocks are symmetrically distributed, and a reinforcing transverse plate is fixedly connected between the two sets of supporting blocks. When the distraction fixator for the kidney transplantation operation is used, the position can be adjusted according to the body position of a patient, then the rectangular frame is installed and fixed to the upper portion of the bottom supporting platform through the lifting supporting mechanism, and the position of the rectangular frame is adjusted according to the weight of the patient; and finally, the distraction arms and the distraction plates can be installed according to the incision condition of the patient, and the distance and the angle between the distraction arms and the distraction plates can be adjusted, so that the distraction effect is guaranteed.

The invention discloses application of a cyclic erythropoietin-derived peptide in protection of renal injury and cyclosporine A injury. In a control group, the abdominal cavity and renal pedicle are exposed; in IR, two renal pedicles are separated, and are clipped with a vessel clamp for 30 minutes to enable color of the kidneys to be changed, and refilling is performed for 2 or 8 weeks; in IR plus CsA, CsA is dissolved in olive oil, and IR mice are subjected to intragastric administration every day; in IR plus CHBP, CHBP is dissolved in saline water, and the IR mice are subjected to intraperitoneal injection every three days; in IR plus CsA plus CHBP, CsA and CHBP are used for treating the IR mice at the same time; urine albumin/creatinine, serum creatinine, histology, apoptosis, caspase-3 and HMGB1 are evaluated, and intracellular signal channels are screened through a protein chip; and a renal epithelial cell model is established, renal injury is simulated, and the influence of CsA,CHBP and/or caspase-3 siRNA on TCMK1 is studied.

Methods and apparatuses for pumping blood within a blood vessel are described. The methods and apparatuses are can be used for renal decongestion by pumping blood through the kidney(s), thereby increasing a pressure gradient across the kidney(s). The apparatuses can include one or more inflatable elements that can be repeatedly inflated and deflated to cause a pumping action within the blood vessel. In some embodiments, the one or more inflatable elements are positioned within one or more stents.

The invention provides a method for establishing a horseshoe kidney animal model. The method comprises: injecting a certain amount of retinoic acid solution at one time in the early pregnancy of the pregnant animal, and routinely feeding and giving birth to obtain the horseshoe kidney animal model. The method for creating an animal model of horseshoe kidney of the present invention has good experimental repeatability, and provides an experimental tool and platform for mechanism research for abnormal kidney development such as horseshoe kidney. Surgical operation and drug evaluation provide an extremely close and convenient experimental tool platform and scientific basis.

The invention discloses a high-simulation ultrasonic and X-ray guided percutaneous nephrocentesis nephroscopy skill training model and a mold thereof. A kidney model is a sample mold, the mold is made of silicon rubber and resin, and precious rubber with the same density as the kidney and surrounding tissues of a human body is formed in the mold and firstly snapped into a kidney area groove of a high-simulation human body model; a nephroscope can be implanted through percutaneous renal puncture under the guidance of ultrasound or X-rays, a renal pelvis, a kidney large calyx, a kidney small calyx and a renal papilla can be observed through the nephroscope, percutaneous renal puncture biopsy, micro-fistulization calculus removal, ultrasound-guided percutaneous nephroscope air pressure ballistic ultrasonic or holmium laser lithotripsy and the like are carried out, the simulation effect is highly simulated, just like operation is carried out on a real patient, and the teaching effect of skill training of skin-kidney puncture nephroscopy can be remarkably improved.

The present invention is directed to KIM-1 polypeptide as a plasma acute and chronic kidney injury and renal cell carcinoma biomarker, and methods and kits comprising the use of agents specific to KIM-1 for facilitating and enhancing the diagnosis of kidney injury or carcinoma. The present invention is based on the discovery that measuring KIM-1 levels in the blood is more accurate and reliable than measuring KIM-1 levels in the urine for the diagnosis of subjects with proximal kidney tubule injury or kidney cancer. The invention is directed to methods for diagnosis of acute kidney injury, chronic kidney disease (CKD), and renal cell cancer by determining and monitoring the levels of KIM-1 polypeptide in a blood sample, such as plasma or serum sample.

The invention discloses application of a medicine composition in preparing medicine capable of protecting heart, kidney and brain tissue target organ. The medicine composition comprises, by weight, 10-30 parts of rhizoma gastrodiae, 10-20 parts of uncaria, 5-15 parts of lotus plumule and 5-15 parts of radix scutellariae. The medicine composition can lower blood pressure, relieve damage caused to specific target organs like heart, brain and kidney, reduce myocardial and renal interstitial fibrosis area, activate astrocyte and improve structural dysfunction of the target organs like heart, kidney and brain in the process of high blood pressure, and an experimental basis is provided for clinical application.

Several embodiments of a catheter are described, having a balloon configured to slowly inflate and then quickly deflate to create an area of low pressure in the vessels. The balloon can be cycled near the vessels of the kidneys, thereby helping to draw out blood from the kidneys and enhance fluid processing to the bladder.

The invention discloses three piericidin natural products and application thereof to preparation of anti-kidney cancer medicines. The three piericidin compounds, namely piericidins G, I and J, are unreported novel compounds. The invention discloses that the piericidin compounds, namely piericidins G, I and J, have the obvious activity in inhibiting two kidney cancer cells, and the piericidins canbe applied to the preparation of the anti-kidney cancer medicines. Therefore, the invention provides alternative compounds for development of the novel anti-kidney cancer medicines and is of a great significance in developing marine microbial medicine resources in China.