26 results about "Two kidney" patented technology

The invention discloses a kidney blood perfusion device used before kidney ischemia, and relates to the field of perfusion devices, the kidney blood perfusion device comprises a machine shell, the side face of the machine shell is provided with a pair of fasteners, and the fasteners are used for fixing syringes respectively; the movable plate is arranged in the machine shell through a moving mechanism, and the moving mechanism can drive the movable plate to move in the machine shell; the pushing parts are arranged on the movable plate and used for pushing a piston handle in the injector, each pushing part comprises a sliding sleeve, a movable sleeve and an elastic component, the sliding sleeves are arranged on the side face of the movable plate, and the movable sleeves are inserted into the sliding sleeves in a sliding mode. The device has the advantages that manual time sequence errors in operation are avoided through double-stage strict separation, reperfusion after blood vessels are closed is ensured, a mechanical interlocking mechanism of a blocking pad and a stroke strip forcibly requires that perfusion can be started only after liquid bag expansion is completed, and the misoperation risk is completely eradicated from the hardware level; the double-stage seamless switching of liquid injection expansion and perfusion is realized, the efficiency is high, the perfusion speed of mechanical pushing injection during perfusion is more uniform, and the effect is better.

1. Name of the product in this design: Kidney cryogenic perfusion transport box. 2. Purpose of this design: for the perfusion, preservation and transport of kidney organs. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present application discloses and claims a kidney phantom consisting of a silicone rubber model featuring the anatomical shape of a human kidney, the renal artery, the renal vein, and a total of 11 tumors and 2 cysts. Each tumor is represented by a solid mass, while cysts are empty three-dimensional shapes. In order to accommodate the needs of both novice and advanced surgeons, tumors were designed with increasing surgical difficulty. The kidney phantom disclosed in the present application can be combined with a commercially available ensemble of laparoscopic tools to provide localized and remote training to surgeons and medical staff practicing laparoscopic and robotic partial nephrectomy.

The utility model discloses an anti-reflux ureteral stent, which belongs to the technical field of ureteral stents and comprises a stent pelvis section, a stent ureteral section and a stent bladder section. At least one hollow expansion part is arranged on the tube wall of the bladder section of the stent, and an integrated anti-reflux valve is arranged in a tube cavity of the expansion part. The valve is composed of a plurality of valve-shaped structures, the free ends of the valve-shaped structures can be close to each other to seal a lumen when subjected to retrograde liquid pressure from the bladder to the kidney, the free ends of the valve-shaped structures are separated from each other to open the lumen when subjected to forward liquid pressure from the kidney to the bladder, and therefore one-way drainage of urine is achieved. The anti-backflow urine bag is simple in structure and capable of effectively preventing backflow of urine and complications such as lumbago and hydronephrosis caused by backflow of urine. Meanwhile, due to the structure of the expansion part, the valve can be completely attached to the wall when opened, and operation smoothness and safety are guaranteed when a guide wire is placed in.

This invention belongs to the field of medical image processing technology, specifically relating to a kidney segmentation method based on key point localization. The method includes the following steps: acquiring medical images of the kidney to be segmented and preprocessing the images; defining a set of anatomical key points specifically for kidney segmentation; predicting the position coordinates of each key point in the key point set using a model; constructing spatial topological relationships between key points based on the predicted key point coordinates and kidney anatomical zoning rules; and dividing the kidney parenchyma into regions according to the spatial topological relationships and kidney anatomical zoning rules, outputting the segmentation results for each kidney segment. This invention achieves efficient and accurate automatic kidney segmentation by precisely detecting anatomical key points and combining them with the anatomical rules of the Graves kidney segment model, outputting segmentation results with anatomical interpretability, and providing reliable technical support for preoperative planning of urological surgeries such as precise nephrectomy.

The utility model belongs to the technical field of medical equipment, and provides a home body position calculus removal guiding device which comprises a fixed base, a movable base and a guide rod. The kidney model is arranged on the fixed base, a ureter is arranged on the kidney model, and the kidney model is a transparent material model; a renal pelvis cavity, a kidney large calyx cavity and a kidney small calyx cavity are formed in the kidney model, and the ureter, the renal pelvis cavity, the kidney large calyx cavity and the kidney small calyx cavity are used for simulating the ureter, the renal pelvis, the kidney large calyx and the kidney small calyx of the human kidney respectively. The transparent kidney model is convenient for the patient to intuitively observe the movement track of the stone-like member in the kidney model under different body positions. When the kidney model is used, a patient can wear the kidney model at the preset position of the waist, and the body position is changed according to the dynamic condition of the stone-like piece in the kidney model until the stone-like piece is discharged out of the pelvis. Therefore, the cost of the body position drainage bed for the patient is reduced, the hospital return frequency of the patient is reduced, and the body position calculus removing efficiency of the patient is improved.

The invention discloses a biomarker for detecting renal fibrosis, application and a system, and relates to the technical field of biological medicines. The invention relates to a biomarker for detecting renal fibrosis. The biomarker comprises urinary copper cyanin. Compared with the conventional diagnostic marker (such as eGFR, RBP, NAG and the like), the urocyanin has the following three advantages: 1, compared with the conventional diagnostic marker (such as eGFR, RBP, NAG and the like), the urocyanin is more sensitive to diagnosis of renal interstitial fibrosis and fibrosis severity; secondly, compared with traumatic renal tissue pathologic biopsy, urine is used as a diagnosis medium, so that true noninvasive effect can be realized, and no harm is caused to the body health of a patient; and thirdly, compared with detection means such as iconography, the method for detecting the urinary cupreocyanin marker is lower in cost, more flexible, high in timeliness and easier to popularize.

The present invention relates to designed ankyrin repeat domains and designed ankyrin repeat proteins for use in reducing accumulation of a therapeutic and / or diagnostic agent in the kidney of a subject treated with said agent. Preferably such therapeutic and / or diagnostic agent comprises a drug moiety such as a radionuclide or a cytotoxin. In addition, the invention provides recombinant proteins comprising such repeat domains, nucleic acids encoding such repeat domains or recombinant proteins, recombinant expression vectors, host cells, and pharmaceutical compositions comprising such repeat domains, recombinant proteins, nucleic acids or recombinant expression vectors, as well as the use of such repeat domains, recombinant proteins or pharmaceutical compositions in methods for reducing accumulation of a therapeutic and / or diagnostic agent in the kidney of a subject treated with said agent.

The invention provides a glomerular filtration rate estimation method and device for a patient with asymmetric double renal functions. The method comprises the following steps: acquiring basic information, clinical data, laboratory detection data and iconography data of a patient, wherein the iconography data comprises kidney volume, blood flow volume, cortex and medullary thickness and kidney function expression of the right kidney and the left kidney; by analyzing iconography data, a functional difference measurement coefficient for quantifying the asymmetry of double kidney functions is calculated. Thirdly, extracting a global feature vector of the patient by using a deep learning model, and performing fusion processing on the iconography data, the clinical data and the laboratory detection data to generate a comprehensive feature vector; and on the basis, the functional weights of the right kidney and the left kidney are adjusted according to the functional difference measurement coefficient, finally, the adjusted functional weights and the global feature vectors are input into a deep regression model, and a corrected GFR estimated value is obtained through calculation. And more accurate renal function evaluation can be provided according to the condition that double renal functions are asymmetric.

This invention relates to the field of pharmaceutical technology, specifically disclosing the application of SRPX2 inhibitors in the preparation of drugs for treating renal fibrosis, including SRPX2 inhibitors. SRPX2 inhibitors regulate the expression of iron metabolism-related proteins by inhibiting the binding of SRPX2 to IRP1, a key regulatory protein in iron metabolism, thereby restoring iron homeostasis and alleviating renal fibrosis. In patients with chronic kidney disease and animal models of renal fibrosis, SRPX2 is highly expressed in renal tubular epithelial cells and is positively correlated with the degree of fibrosis. The use of SRPX2 inhibitors can significantly reduce the pathological changes of renal fibrosis and improve renal function. This invention provides a new treatment strategy and drug candidate for renal fibrosis.

The present document relates to a method implemented by computer means for estimating, on a dynamic renal scintigraphy of both kidneys of a patient, a split renal function for a transfer renal function of a tracer in the kidneys, said dynamic renal scintigraphy comprising a series of images taken over a global time sequence. The method's automated approach to estimating split renal function on dynamic renal scintigraphy streamlines the process by reducing the need for manual intervention and specialized training. This not only saves time but also minimizes the potential for human error in the calculation process. The computer-implemented steps provide a standardized and reproducible method for calculating the split renal function, in order to assess the relative contribution of each kidney to the overall renal function in a patient.

A system includes a processor circuit configured to receive an endovascular flow measurement obtained by an endovascular flow measurement positioned within a blood vessel of a patient. The system controls a nerve stimulation device to stimulate a nerve of the patient and receives an additional endovascular flow measurement while the nerve is stimulated. The processor circuit then performs a comparison of the two flow measurements received and provides an output based on the comparison.

Provided herein are methods and kits for treating kidney-related diseases disorders, and complications, such as Berger's disease and kidney transplant rejections. Also provided are methods of predicting or measuring a response to a treatment by measuring biomarker levels in a sample, and methods of modulating biomarker levels.

Embodiments described herein relate to methods and compositions for diagnosis, monitoring, classifying, staging and determination of treatment regimens in subjects with or at risk of kidney disease and / or all-cause mortality by determining the level of an amino acid or nucleic acid in a biological fluid, such as urine. In certain aspects the subjects are diagnosed with diabetes (or other underlying risk factor for kidney disease such as hypertension) and have normal levels of urine albumin. Additionally, disclosed herein are methods of treating a condition of fibrosis by inhibiting production or function of adenine.

The present invention relates to a normothermic perfusion device to maintain optimal physiological conditions for both a liver and a kidney intended to be transplanted, comprising a permanent part and a disposable part, wherein the disposable part comprises a container adapted to house a liver or a kidney and a hydraulic circuit comprising at least one first tube that channels a perfusion fluid externally pumped to the container to the liver or kidney, a second tube that channels a vasodilator fluid to the liver or kidney, and wherein the permanent part comprises in an upper portion a relief configured to house, at least, two containers of different dimensions and geometric configurations.

The application discloses a multifunctional kidney ureteral catheter and relates to the technical field of medical devices; the multifunctional kidney ureteral catheter comprises a ureter, a detection pipeline and a detection device; the pressure sensor cooperates with the valve plate with switchable flow paths, so that the urine flow of the left and right kidneys can be detected at different times and respectively, unilateral kidney function independent monitoring is realized, the real working state of the double kidneys can be accurately reflected, the problem that the traditional mode can only measure the total urine volume and cannot judge unilateral abnormalities is avoided, and when the air bag leaks, the piston in the liquid storage shell can intuitively prompt medical staff and patients through position change, and the air bag inflation can be temporarily supplemented and maintained through normal saline, so that failure early warning is realized, the stent can be prevented from immediately falling off, and the use safety is improved.

The application provides a KIM-1 specific binding kidney targeting polypeptide and application thereof in preparation of a medicine for treating kidney diseases, and an amino acid sequence of the KIM-1 specific binding kidney targeting polypeptide is shown as SEQ ID NO. 1. In the application, the targeting polypeptide can be specifically combined with an extracellular Ig V domain of kidney injury molecule-1 (KIM-1 / HAVCR1), so that kidney targeting and treatment effect on the damaged kidney can be realized after the occurrence of kidney diseases such as kidney injury.

The invention discloses a method for constructing a renal ischemia reperfusion mouse model, and relates to the technical field of animal model construction, and the method is characterized by comprising the following steps: S1, anesthetizing a mouse; s2, fixing and disinfecting the mouse; s3, cutting the skin, separating layer by layer, and exposing kidney tissues and blood vessels; the kidney is rotated by 360 degrees with the renal artery as the axis, the rotation state is maintained for 30 minutes, and then the kidney is reset to open renal blood flow; and S5, suturing the surgical incision. According to the constructed mouse model, on the basis of effectively blocking artery blood flow, the complexity of surgical operation is reduced, the total renal artery is protected to the maximum extent, renal blood flow supply after recanalization is guaranteed, and the renal artery blood flow is blocked within a certain time without damaging blood vessels. And a good and stable animal model is provided for better researching the mechanism of acute kidney injury and innovative treatment schemes in the future.

To provide a method and a system for predicting acute renal diseases that accurately predict whether an acute renal disease is in progress.SOLUTION: An acute renal disease prediction system includes an input device, a storage device, a processor, and an output device. A prediction method of the acute renal disease prediction system includes: a step of inputting multiple pieces of immune cell group data, a blood serum creatinine value and a urea nitrogen value, and storing them in the storage device; a step of accessing the storage device, and constructing an acute renal disease prediction model via a decision tree algorithm using the multiple pieces of immune cell group data, the blood serum creatinine value and the urea nitrogen value as parameters; a step of acquiring the immune cell group data, the blood serum creatinine value and the urea nitrogen value that are evaluation objects, and acquiring a determination result procedure of acute renal diseases by executing a determination procedure; and a step of outputting a determination result of acute renal diseases.SELECTED DRAWING: Figure 1

The invention relates to the technical field of kidney transplantation, in particular to an edge kidney supply mechanical perfusion repair device which comprises a perfusion box body, a partition plate is arranged in the perfusion box body and divides the interior of the perfusion box body into a containing cavity and a pump body cavity, an ice block cavity is formed above the containing cavity, and a fixing assembly is arranged in the containing cavity. A lifting assembly used for adjusting the inclination angle of the fixing assembly is arranged at the bottom of the fixing assembly, a pump assembly is arranged in the pump body cavity and communicates with a connecting pipe, one end of the connecting pipe penetrates through the pump body cavity and extends into the containing cavity to communicate with the kidney body, and the connecting pipe is of a corrugated structure. A first ice bag and a second ice bag are fixedly connected to the inner side wall of the containing cavity and the partition plate correspondingly, and a plurality of spines are arranged on the sides, close to the fixing table, in the first ice bag and the second ice bag correspondingly. The lifting assembly is matched with the corrugated connecting pipe to discharge bubbles and crush ice blocks when the lifting assembly inclines, the problems that an existing device is frequent in temperature alarm, abnormal in pressure and flow speed and the like are solved, and stable perfusion repair of the marginal donor kidney is achieved.

The present invention relates to a method for reducing blood pressure by stimulating lymphatic vessel growth and / or lymphangiogenesis in the kidneys.

FIELD: medicine.SUBSTANCE: invention relates to operative urology, namely to surgical treatment of recurrent strictures of the pyeloureteral junction (PUJ) affecting the PUJ and ureter, when resection of the narrowed PUJ segment and performing an anastomosis of the renal pelvis with the ureter is impossible. The scarred narrowed segment of the ureterocalycopyeloanastomosis is isolated. Resection of the altered part of the ureter and the kidney parenchyma above the dilated lower calyx is performed. The posterior edges of the ureter and the lower calyx are connected with three interrupted sutures without tension, a stent is placed antegradely. A buccal mucosal graft is placed on the anterior part of the anastomosis.EFFECT: possibility to perform resection of the narrowed part of the ureter and restore patency of the upper urinary tract, form a wide lumen of the anastomosis between the lower calyx and the ureter by augmenting it with a buccal graft, which provides optimal urine outflow from the kidney, minimise the percentage of recurrence.1 cl, 3 dwg, 1 ex