75 results about "Two kidney" patented technology

A method for treating congestive heart failure (CHF) has been developed that restores kidney renal functions by artificial vasodilation of at least one kidney. A vasodilator drug is locally delivered to the kidney via a kidney perfusion catheter. The drug can be mixed with the patient's blood, saline or other suitable solvent and the mixture directly applied to the kidney through the catheter. The restoration of kidney function assists the heart by removing excess fluid, urine and toxin from the patient, and by normalizing the patient's renin-angiotensin system and other neurohormonal substances. The method is applicable to treat chronic and acute CHF.

Methods of detecting or predicting the onset or magnitude of kidney diseases such as acute kidney disease (AKI), previously called acute renal failure (ARF), are provided. In various aspects, methods and kits are provided to detect specific urinary proteins associated with AKI diagnosis or prognosis such as, e.g., angiotensinogen.

To accomplish isolation and removal of a substance from a vasculature, a catheter is employed to occlude a vessel of the vasculature. The substance is thus isolated in the vasculature and can be removed. In this way, the substance is removed before entering other parts of the circulatory system. This method is applicable to removal of contrast from the coronary sinus shortly after injection of the coronary arteries with the contrast. The method substantially minimizes or avoids renal dysfunction caused by angiographic procedures in which contrast must be injected. Such angiographic procedures are often performed during intervention procedures. This method substantially prevents circulation of the contrast to the kidneys where it could otherwise cause renal dysfunction or failure. The apparatus for implementation of the method is also disclosed.

It is an object of the present invention to provide a combination of a functional assessment of renal function together with biomarker results in order to improve assessment of patient at risk of or having, an acute kidney injury. A loop diuretic such as furosemide inhibits luminal active chloride transport throughout the thick ascending limb of Henle, thereby preventing sodium reabsorption and resulting in natriuresis and increased urine flow. Loop diuretic-induced increases in urine output might be a method to assess the integrity of the renal tubular function in the setting of early AKI, and so a kidney's response, or lack thereof, to a diuretic challenge as a clinical assessment of tubular function can identify patients with severe tubular injury before it is clinically apparent (e.g. a rise in creatinine).

Improved devices, systems, and methods treatment of patients can be used to help mitigate injury to the kidneys by applying cyclical mechanical pressure energy at low intensities. The energy often be selectively directed from non-invasive transducers disposed outside the patients. The energy will typically comprise low frequency ultrasound energy, shock wave energy, or the like, and may induce the generation and / or release of nitric oxide, thereby enhancing perfusion and ameliorating tissue damage. Superimposed micro and macro duty cycles may help avoid thermal and other injury to tissues of the patient during treatment. Bilateral treatments are facilitated by a support structure that orients at least one transducer toward each kidney.

The present invention relates to a mechanical perfusion system for preservation of both isolated kidneys. The system comprises: (1) a perfusion liquid temperature control groove for holding a perfusion liquid; (2) two sets of isolated kidney preservation grooves for holding isolated kidneys; (3) pipelines connected between the perfusion liquid temperature control groove and the isolated kidney preservation grooves and used for conveying the perfusion liquid to the isolated kidneys; (4) a pressure detection module for detecting the pressures of the pipelines; (5) a flow rate detection module for detecting the flow rates of the pipelines; (6) a gas bubble detection module for detecting the gas bubbles of the pipelines; (7) an electromagnetic valve module for controlling the on-off of a liquid path; (8) a sampling module for extracting the perfusion liquid; (9) a control module for controlling a peristaltic pump and the electromagnetic valve module; and (10) a display module for displaying the pressures and the flow rates of the pipelines, and the resistance coefficient of the kidney organ.

A method and apparatus for monitoring a kidney that consists of monitoring the corticomedullary sodium concentration gradient in a kidney by an imaging technique selected from the group consisting of MRI, optical imaging, computed tomography (CT), ultrasound or positron emission tomography (PET), to obtain dynamic images; processing the obtained images to quantitatively determine, pixel by pixel of the images, the concentration of sodium along the corticomedullary axis of the kidney; and mapping the sodium distribution at high resolution to indicate the sodium concentration gradient of the corticomedullary axis of the kidney. Preferably the monitoring is carried out using 23Na MRI. Maps of the sodium distribution are displayed.

Processes of localizing target papillas of renal anatomy involve advancing a ureteroscope to a target calyx of a kidney of a patient through at least a portion of a urinary tract of the patient, determining a positional offset between one or more position sensors associated with the ureteroscope and a target papilla of the kidney that is at least partially exposed within the target calyx, and determining a percutaneous access target based at least in part on one or more of a present position of the one or more position sensors and the offset.

The present invention provides compositions and methods for the detection, treatment, and prevention of a kidney injury. The invention relates to the discovery that chitinase 3-like 1 / Brp-39 / YKL-40 serves as both a biomarker for the degree of kidney injury and a critical mediator of a reparative response in the kidney.

The invention discloses a ureter ligation induced non-human primate animal renal fibrosis model building method and application. The specific technical scheme includes that an experimental monkey is anaesthetized by anesthetics, surgical anesthesia is maintained, the abdomen of the experimental monkey is cut apart along a medioventral line after disinfection, an abdominal cavity is opened, an operation field is exposed, a unilateral ureter at a unilateral renal lower edge is ligated twice by a surgical silk thread and completely blocked, another kidney is not ligated and serves as a self-body for comparison, a wound is stitched in a layered manner after a surgical incision is disinfected, renal fibrosis indexes are measured by biological samples at different time points after ligation, or a left kidney and a right kidney are taken down and fixed in neutral buffered formalin, and formalin fixed kidney samples are subjected to tissue section and pathological examination. An animal model has application values which cannot be realized by an existing rodent and rabbit animal model, and the non-human primate animal model built by the method has wide application in related fields of fibrosis.

The invention relates to a method to prevent contrast-induced nephropathy during an imaging procedure. The method includes steps of positioning balloon catheters in a patient's renal arteries and renal veins and inflating the balloons of each catheter to block the flow of contrast media into the patient's kidneys.

The invention discloses a distraction fixator for a kidney transplantation operation, and relates to the field of kidney transplantation operations. The distraction fixator for the kidney transplantation operation comprises a bed body, a supporting and positioning base, a lifting supporting mechanism and a distraction fixator structure, the bottom of the bed body is fixedly connected with two sets of supporting blocks, the two sets of supporting blocks are symmetrically distributed, and a reinforcing transverse plate is fixedly connected between the two sets of supporting blocks. When the distraction fixator for the kidney transplantation operation is used, the position can be adjusted according to the body position of a patient, then the rectangular frame is installed and fixed to the upper portion of the bottom supporting platform through the lifting supporting mechanism, and the position of the rectangular frame is adjusted according to the weight of the patient; and finally, the distraction arms and the distraction plates can be installed according to the incision condition of the patient, and the distance and the angle between the distraction arms and the distraction plates can be adjusted, so that the distraction effect is guaranteed.

The invention discloses an isolated kidney perfusion system, and relates to the technical field of kidney transplantation. According to the invention, a liquid conveying pipeline is used as a main body; a liquid inlet pipe, a liquid dripping bucket, a fluid speed regulation roller and an outflow assembly are sequentially arranged on the conveying pipeline in series; and through arrangement of theabove-mentioned structures, the isolated kidney perfusion system provided by the invention can make up the defect that a perfusion device used in the kidney transplantation process in the prior art isgenerally a self-made simple device and is inconvenient when a plurality of blood vessels are encountered or the blood vessels are thin. During kidney perfusion, a medicine can be injected through above-mentioned devices; a flow speed can be adjusted through a pulley; a pressure can be generated during liquid conversion and extrusion through a soft ball to facilitate perfusion; a proper siliconetube can be selected for perfusion according to the thickness and number of kidney arteries; thus, the isolated kidney perfusion system provided by the invention has the advantages of simple structure, widely-available materials, convenient operation, low price, practicality, sufficient perfusion, scientific and reasonable structure and safe and convenient use.

The invention discloses application of a cyclic erythropoietin-derived peptide in protection of renal injury and cyclosporine A injury. In a control group, the abdominal cavity and renal pedicle are exposed; in IR, two renal pedicles are separated, and are clipped with a vessel clamp for 30 minutes to enable color of the kidneys to be changed, and refilling is performed for 2 or 8 weeks; in IR plus CsA, CsA is dissolved in olive oil, and IR mice are subjected to intragastric administration every day; in IR plus CHBP, CHBP is dissolved in saline water, and the IR mice are subjected to intraperitoneal injection every three days; in IR plus CsA plus CHBP, CsA and CHBP are used for treating the IR mice at the same time; urine albumin / creatinine, serum creatinine, histology, apoptosis, caspase-3 and HMGB1 are evaluated, and intracellular signal channels are screened through a protein chip; and a renal epithelial cell model is established, renal injury is simulated, and the influence of CsA,CHBP and / or caspase-3 siRNA on TCMK1 is studied.

Methods and apparatuses for pumping blood within a blood vessel are described. The methods and apparatuses are can be used for renal decongestion by pumping blood through the kidney(s), thereby increasing a pressure gradient across the kidney(s). The apparatuses can include one or more inflatable elements that can be repeatedly inflated and deflated to cause a pumping action within the blood vessel. In some embodiments, the one or more inflatable elements are positioned within one or more stents.

In some preferred embodiments, a system for the automatic identification of cortical and / or medulla regions of the kidneys in renal dynamic studies is provided that includes: a computer module configured to perform principal component analysis on a dynamic sequence corresponding to only one of the kidneys based on a linear combination of the first few component images with coefficients for the principal component analysis as normalization factors.

The p21 biomarker is utilized in the evaluation of whether a patient is suffering from kidney injury or failure, and can be used in methods of treating kidney injury or failure by determining the appropriateness of one or more of initiating renal replacement therapy, withdrawing delivery of compounds that are known to be damaging to the kidney, delaying or avoiding procedures that are known to be damaging to the kidney, and modifying diuretic administration.

The invention provides a method for establishing a horseshoe kidney animal model. The method comprises: injecting a certain amount of retinoic acid solution at one time in the early pregnancy of the pregnant animal, and routinely feeding and giving birth to obtain the horseshoe kidney animal model. The method for creating an animal model of horseshoe kidney of the present invention has good experimental repeatability, and provides an experimental tool and platform for mechanism research for abnormal kidney development such as horseshoe kidney. Surgical operation and drug evaluation provide an extremely close and convenient experimental tool platform and scientific basis.

The invention discloses a high-simulation ultrasonic and X-ray guided percutaneous nephrocentesis nephroscopy skill training model and a mold thereof. A kidney model is a sample mold, the mold is made of silicon rubber and resin, and precious rubber with the same density as the kidney and surrounding tissues of a human body is formed in the mold and firstly snapped into a kidney area groove of a high-simulation human body model; a nephroscope can be implanted through percutaneous renal puncture under the guidance of ultrasound or X-rays, a renal pelvis, a kidney large calyx, a kidney small calyx and a renal papilla can be observed through the nephroscope, percutaneous renal puncture biopsy, micro-fistulization calculus removal, ultrasound-guided percutaneous nephroscope air pressure ballistic ultrasonic or holmium laser lithotripsy and the like are carried out, the simulation effect is highly simulated, just like operation is carried out on a real patient, and the teaching effect of skill training of skin-kidney puncture nephroscopy can be remarkably improved.

The present invention is directed to KIM-1 polypeptide as a plasma acute and chronic kidney injury and renal cell carcinoma biomarker, and methods and kits comprising the use of agents specific to KIM-1 for facilitating and enhancing the diagnosis of kidney injury or carcinoma. The present invention is based on the discovery that measuring KIM-1 levels in the blood is more accurate and reliable than measuring KIM-1 levels in the urine for the diagnosis of subjects with proximal kidney tubule injury or kidney cancer. The invention is directed to methods for diagnosis of acute kidney injury, chronic kidney disease (CKD), and renal cell cancer by determining and monitoring the levels of KIM-1 polypeptide in a blood sample, such as plasma or serum sample.

This document provides methods and materials involved in assessing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials involved in assessing outcomes. For example, methods and materials for using the level of urinary CNP (e.g., a urinary to plasma CNP ratio) to determine whether or not a mammal is developing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials for using the level of urinary CNP levels to identify patients having an increased likelihood of experiencing a poor outcome are provided.

The present invention relates to means and methods for modifying renal function in a subject, comprising selecting a patient requiring an increment in renal function; emitting a quantity of ultrasound radiation, enough to provide an increment in renal function, to at least one part of a kidney for a period of time from about 1 hours to about 30 days.

The invention discloses a method for automatically evaluating difficulty of kidney tumor enucleation based on CT (computed tomography) images, which comprises the following steps: based on artificial intelligence and image analysis technologies, segmenting an abdominal wall, a kidney and a kidney tumor at the same time by establishing a deep network model, automatically calculating an MAP score and an R.E.N.A.L score by utilizing relevance among the tumor, a renal pelvis, the kidney and the abdominal wall, and automatically evaluating the difficulty of the kidney tumor enucleation based on the CT images. Therefore, the difficulty of the kidney tumor enucleation is reasonably and effectively evaluated; the method has the advantages of time and labor saving and high evaluation accuracy and reliability.

The present invention relates to the context of renal denervation. In order to provide further improvement in relation to the outcome of renal denervation, an apparatus (10) for renal denervation preparation is provided that comprises an input unit (12), ha processing unit (14) and an output unit (16). The input unit is configured to receive first artery parameter data and second artery Ge parameter data. The first artery parameter data relates to artery stiffness of a renal artery part of a subject, and the second artery parameter In data relates to artery stiffness of a non-renal artery part of the subject. The processing unit is configured to calculate a respective vessel stiffness for the renal artery part based on the first artery parameter data, and to calculate a respective vessel stiffness for the non-renal artery part based on the second artery parameter data, and also to determine a response parameter for renal denervation based on the vessel stiffness for the renal artery part and the vessel stiffness for the non-renal artery part. The output unit is then configured to provide the response parameter.

The present teaching relates to interactive medical image processing for surgical procedure planning. In one example, a three dimensional (3D) image of a kidney is obtained. The three dimensional image is rendered on a display screen. An input is received from a user specifying a location with respect to a representation of the kidney in the rendered three dimensional image. A representation of an instrument is rendered on the display screen based on the location. The instrument is automatically aligned with an infundibulum pathway of calyx at the location with respect to the kidney. A graphical line extension is rendered on the display screen to visualize the alignment of the instrument. One or more measurements related to the kidney are determined based on the location and an anatomical structure of the kidney.

The invention discloses application of a medicine composition in preparing medicine capable of protecting heart, kidney and brain tissue target organ. The medicine composition comprises, by weight, 10-30 parts of rhizoma gastrodiae, 10-20 parts of uncaria, 5-15 parts of lotus plumule and 5-15 parts of radix scutellariae. The medicine composition can lower blood pressure, relieve damage caused to specific target organs like heart, brain and kidney, reduce myocardial and renal interstitial fibrosis area, activate astrocyte and improve structural dysfunction of the target organs like heart, kidney and brain in the process of high blood pressure, and an experimental basis is provided for clinical application.

The invention belongs to the field of diagnostic pharmacology, and relates to the use of nano-gold probes in the early diagnosis of kidney damage, especially the use of nano-gold probes in the early diagnosis of kidney damage in diabetic nephropathy. The experimental results of the present invention show that the kidney damage induced under the condition of unilateral ureteral obstruction and release can be detected by the nano gold probe, but cannot be detected by traditional blood biochemical indicators and tissue section methods. Indicating the role of nano-gold probes in the early diagnosis of kidney injury. The nano-gold probe of the present invention detects kidney damage through different particle sizes, and the nano-gold probe of the present invention provides meaningful reference data and support for a new method of diagnosing kidney damage.