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Use of astragalus root in preparing medicine for dilating blood vessel

A technology of dilating blood vessels and medicines, applied in the application field of astragalus in the preparation of vasodilating medicines, which can solve the problems of unclear astragalus and achieve the effect of expanding the scope of medicine

Inactive Publication Date: 2007-12-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, it is not clear whether Astragalus can be used alone as a vasomodulatory drug for the treatment of vascular complications and / or comorbidities such as heart, brain, kidney, and limbs.

Method used

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  • Use of astragalus root in preparing medicine for dilating blood vessel
  • Use of astragalus root in preparing medicine for dilating blood vessel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of Rat Isolated Aortic Ring

[0021] 1. Experimental drug

[0022] Astragalus injection is produced by Chengdu Di'ao Pharmaceutical Co., Ltd., containing 2g of Astragalus raw material per milliliter, and containing astragaloside ≥ 0.03mg.

[0023] 2. Experimental steps:

[0024] Clean grade male Sprague-Dawley (SD) rats, weighing 240-260g.

[0025] Rapidly dissociate the thoracic aorta of SD rats and place at 4°C containing 95% O 2 and 5% CO 2 In the K-H liquid pre-saturated with mixed gas, the surrounding connective tissue was removed and cut into vascular rings of 3-4 mm. During this period, care should be taken to protect the intima of the vascular rings from damage. According to the needs of the experiment, the method of rubbing the inner surface of the vascular ring with a cotton swab was used to prepare a part of the vascular ring as a model in which the endothelium was removed. Then the vascular ring was suspended in a bath pre-prepared...

Embodiment 2

[0026] Example 2 Effect of Radix Astragali on the Relaxation and Contraction Function of the Isolated Aortic Ring

[0027] (1) Observing the effect of Astragalus membranaceus on the tension of the vascular ring in the basic state

[0028] The source of Radix Astragali is the same as in Example 1. Using the cumulative dosing method, add Astragalus membranaceus once every 10 minutes, and observe the cumulative administration of Astragalus membranaceus 0.01-3.0g·L -1 Effects on endothelial integrity and endothelial removal of vascular rings; in the control group, K-H solution was added instead of astragalus.

[0029] (2) Effect of astragalus on tension of PE or KCl pre-contracted vascular ring

[0030] 60mmol·L -1 KCl or 0.3μmol·L -1 PE pre-shrinks the vascular ring with complete endothelium, and adds astragalus 0.01-3.0 g L every 10 min -1 , to observe its effect on pre-contracted endothelial integrity and endothelial removal of vascular ring tension; the control group was ...

Embodiment 3

[0033] Example 3 Effects of Radix Astragali on the diastolic function of different pretreatment aortic rings

[0034] According to the above experimental results, it was found that when the Astragalus concentration accumulated to 3.0g / L, its effect had reached the maximum degree of stability, so the concentration of 3.0g / L was selected for the next experiment, and the source of Astragalus was the same as in Example 1.

[0035] (1) The effect of astragalus on the intact vascular ring of endothelium

[0036] With nitric oxide synthase (NOS) inhibitor L-nitroarginine methyl ester (N(ω)-nitro-L-arginine-methyl-ester, L-NAME) (0.1mmol·L -1 ) or guanylate cyclase inhibitor methylene blue (10 μmol L -1 ) to pretreat the vascular ring with intact endothelium for 15 min, and then use 0.3 μmol·L -1 PE preconstricts blood vessels, observes Astragalus (3.0g·L -1 ) on the contraction of vascular ring tension; the control group was added with K-H solution instead of astragalus.

[0037...

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Abstract

An application of astragalus root in preparing the blood vessel dilating medicine for treating hypertension and angina pectoris is disclosed. Said medicine may be particles, tablet, capsule, softgel, dripping pills, oral liquid, or injection.

Description

technical field [0001] The invention relates to the application of the traditional Chinese medicine astragalus, and mainly relates to the application of the traditional Chinese medicine astragalus in the preparation of vasodilator drugs, which is suitable for the preparation of blood pressure lowering drugs and also for the preparation of antiangina pectoris drugs. Background technique [0002] In my country, high blood pressure is a common cardiovascular disease with a high prevalence rate, and its heart, brain, kidney, limbs and other vascular complications and / or complications lead to mortality and disability among various diseases First of all, it is extremely harmful to human health. According to the results of the national census in 1991, the prevalence rate of hypertension in my country was 11.88%. The third sampling survey in Zhejiang Province in 2003 showed that the prevalence rate of hypertension in Zhejiang Province increased by 275% within 13 years. At present, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481A61K9/16A61K9/20A61K9/48A61K9/08A61K9/10A61P9/12A61P9/10
Inventor 胡申江张必祺
Owner ZHEJIANG UNIV
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