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Medical application of beta-glucan in prevention and treatment of leptospirosis

A technology of leptospirosis and leptospirosis, applied in the field of medicine, to achieve the effect of reducing inflammation, expanding the scope of medicinal use, and reducing the use

Inactive Publication Date: 2020-02-14
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the application in the prevention and treatment of leptospirosis

Method used

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  • Medical application of beta-glucan in prevention and treatment of leptospirosis
  • Medical application of beta-glucan in prevention and treatment of leptospirosis
  • Medical application of beta-glucan in prevention and treatment of leptospirosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] β-glucan as a drug for the prevention and treatment of leptospirosis.

Embodiment 2

[0020] The β-glucan is suitable for any pharmaceutically acceptable carrier as a medicine for preventing and treating leptospirosis.

Embodiment 3

[0022] The pharmaceutical preparation used is a liquid preparation of a β-glucan standard product, and the β-glucan powder is dissolved and diluted with physiological saline according to the dosage.

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PUM

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Abstract

The invention provides a medical application of beta-glucan in preparation of a medicine for preventing and treating leptospirosis. In the invention, a beta-glucan standard substance is applied to administration of leptospira-sensitive golden hamster. Beta-glucan injection is conducted before infection, during infection and after infection, the injection dosage is 10 mg / kg, and the infection dosage is 1x10<7> / ml. The invention finds that the beta-glucan can effectively control leptospira infection, reduce inflammatory response of individual organs and increase the survival rate of the golden hamster to 100%. The invention provides a new method for treating leptospirosis, the medicinal range of the beta-glucan is expanded, and a basis is provided for new application of the beta-glucan.

Description

technical field [0001] The invention discloses a medical application of β-glucan in preventing and treating leptospirosis, provides a new medical application of β-glucan, and belongs to the technical field of medicine. Background technique [0002] Leptospirosis, referred to as leptospirosis, is a natural foci zoonotic disease that spreads worldwide. It is found in most parts of China, and the prevalence varies from region to region. It is the most serious and has great harm to people's health and livestock health. The mode of transmission of leptospirosis is mainly contact transmission. The initial clinical symptoms of infected people and livestock are fever, headache, conjunctival hyperemia, lymphadenopathy, vomiting, and diarrhea. It is easy to be confused with influenza and difficult to diagnose. And the pathogen persists in the host, spreads and spreads with the host, causing infection of other animals. Currently, the methods of preventing and treating Leptospira are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/716A61P31/04
CPCA61K31/716A61P31/04Y02A50/30
Inventor 曹永国丁越张文龙宋宁王佳琪谢旭峰张石磊吴殿军吕天宝
Owner JILIN UNIV
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