Batch preparation method for circular biological membrane

Abstract

The invention provides a method for batch production of circular biofilms, which includes the following steps: 1) making a model in advance with an elliptical cross-section and a "U"-shaped apex angle on the long side, and the apex angle coincides with the fracture line section; 2) making the model Immerse in the first solution layer and the second solution layer in turn, the first solution forms an elastic layer, which is a dense degradable or non-degradable biofilm, the second solution layer forms a drug layer, and the material of the drug layer is biocompatible with human bone Degradable or non-degradable, absorbent or non-absorbable or porous and loose substances, drugs that can promote bone healing are also encapsulated inside the drug layer; 3) After the biological microstructure membrane is air-dried and the shape is fixed, the required size The prepared biological microstructure membrane is cut along the circumference of the ellipse of the cross-section of the model, and the ring-shaped biofilm after cutting is peeled off from the top corner of the model.

Description

technical field [0001] The invention relates to a method for batch production of circular biofilms. Background technique [0002] At present, it is a frontier field of medical research to use a biocomposite film containing growth factors / stem cells to stick to the fracture line to enhance the speed and quality of fracture healing. There are blood vessels and bone cells distributed on the inner surface of the fracture line (anastomosis line), and whether the healing is good depends on the growth of blood vessels and bone cells in the fracture line. The reason why biofilm sticking to the surface of fracture anastomosis can increase the quality of fracture healing is that on the one hand, the drugs encapsulated in the biofilm can promote the growth of blood vessels and bone cells in the fracture anastomosis, and on the other hand, the biological The membrane isolates external muscles and other human tissues from the fracture anastomotic line, and prevents the reaction of human...

AI Technical Summary

Problems solved by technology

[0004] 1. The biocomposite membrane has a relatively large volume area and a small fracture area, and 2 cannot be effectively fitted and fixed together

[0005] 2. The limitations of the current biocomposite membrane materials and manufacturing process lead to performance indicators such as the degradation rate of the biocomposite membrane and the time for the carried growth factors to release the effective drug concentration (the duration of the effective concentration is the key to the healing quality of the fracture line) Unable to meet clinical needs

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