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Coenzyme Q10 capsule and preparation method thereof

A technology of coenzymes and capsules, which can be used in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., and can solve the problem of high cost

Inactive Publication Date: 2018-03-09
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of these auxiliary materials in China are imported, and their cost is relatively high.

Method used

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  • Coenzyme Q10 capsule and preparation method thereof
  • Coenzyme Q10 capsule and preparation method thereof
  • Coenzyme Q10 capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]

[0026] Preparation Process:

[0027] 1) Pass each ingredient in the formula through an 80-mesh sieve, and set aside.

[0028] (2) Combine coenzyme Q with 10 After the auxiliary materials are mixed evenly, add the soft material made of adhesive, and bake at about 45°C until dry.

[0029] (3) Whole grains, add lubricant, mix evenly, and fill

Embodiment 2

[0031]

[0032] Preparation Process:

[0033] (1) Pass each ingredient in the formula through an 80-mesh sieve, and set aside.

[0034] (2) Coenzyme Q 10 After mixing evenly with the auxiliary materials, add the soft material made of adhesive, and bake at about 45C until dry.

[0035] (3) Whole grains, add lubricant, mix evenly, and fill

Embodiment 3

[0037]

[0038] Preparation Process:

[0039] (1) Pass each ingredient in the formula through an 80-mesh sieve, and set aside.

[0040] (2) Coenzyme Q 10 After mixing evenly with the auxiliary materials, add the soft material made of adhesive, and bake at about 45C until dry.

[0041] (3) Whole grains, add lubricant, mix evenly, and fill

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Abstract

The invention discloses a coenzyme Q10 capsule and a preparation method thereof. The coenzyme Q10 capsule is characterized by being prepared from coenzyme Q10 crude drugs and pharmaceutically acceptable excipients; coenzyme Q10 is uniformly mixed with the excipients, and then wet granulation and whole grain filling are adopted to obtain the coenzyme Q10 capsule. According to the preparation methoddisclosed by the invention, proper excipients are selected, and sldium lauryl sulfate is added into an adhesive and is used as a lubricating agent, so that the stability of a medicine is improved, and the disintegration speed of the medicine is also increased. The prepared granules are uniform and good in mobility; the disintegration, content uniformity and related substances of the capsule all meet the requirements; in addition, the stability of the capsule is better than that of an imported preparation. The method disclosed by the invention has the advantages of simplicity, low cost of theexcipients, good sample stability and suitability for industrial mass production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a preparation method of coenzyme Q10 capsules and preparations thereof. Background technique [0002] Coenzyme Q10 was discovered in 1957. In 1958, the father of coenzyme Q10 research - Dr. Karu Fulukas of the University of Texas in the United States identified its chemical structure, and thus won the highest honor of the American Chemical Society - priestlymedal, but it was not until 1978 Dr. Mitchell of the University of Edinburgh discovered the exact efficacy of coenzyme Q10 in 2010, and made some new breakthroughs and progress in the research on enzymes and metabolism. For the first time, he put forward his viewpoints of "chemical osmosis theory" and "biofilm has transformation activity" to study the law of transformation of bioenergy. His theory is applicable not only to plants, but also to elucidating the energy metabolism of bacterial cells...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/122A61K47/36A61K47/26A61K47/20A61P9/10
CPCA61K9/1617A61K9/1623A61K9/1652A61K31/122
Inventor 曾培安胡良红吴健民张静
Owner KAMP PHARMA
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