A kind of liquid embolism composition loaded with sodium bicarbonate powder and application thereof

A technology of liquid embolic agents and sodium bicarbonate, applied in application, drug combination, suppository delivery, etc., to achieve good biocompatibility, safe application, and stable and reliable embolization effect

Active Publication Date: 2020-02-18
杭州华微医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to international comprehensive reports, the average objective effective rate of cTACE treatment is only 35%.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 5g of EVOH polymer was heated and stirred with 30mL of N-methylpyrrolidone to dissolve, the sulfonating agent used was 5g of concentrated sulfuric acid, and a small amount of about 0.01g of silver sulfate was added as a catalyst to accelerate the reaction. After heating and stirring at 70°C for 3 hours, the mixture was cooled at room temperature. Pour the cooled copolymer into 200mL-300mL methanol to make it precipitate, take the precipitate and add 25mL N-methylpyrrolidone to redissolve it, add 200mL-300mL methanol to make it precipitate again, repeat this several times, and finally remove the precipitate things dry. Or use vacuum drying. Mix the finally obtained sulfonated modified EVOH copolymer, N-methylpyrrolidone, Ta powder developer, and micron-sized baking soda powder in a certain proportion, stir and dissolve, and obtain the liquid embolism agent HW01 of the present invention.

Embodiment 2

[0029] Example 2 5g of EVOH polymer was heated and stirred with 30mL of N-methylpyrrolidone to dissolve, the sulfonating agent used was 2.5g of concentrated sulfuric acid, and a small amount of about 0.01g of silver sulfate was added as a catalyst to accelerate the reaction. After heating and stirring at 70°C for 3 hours, the mixture was cooled at room temperature. Pour the cooled copolymer into 200mL-300mL methanol to make it precipitate, take the precipitate and add 25mL N-methylpyrrolidone to dissolve it again, add 200mL-300mL methanol to make it precipitate again, repeat this several times, and finally remove the precipitate dry. Or use vacuum drying. Mix the finally obtained sulfonated modified EVOH copolymer, N-methylpyrrolidone, Ta powder developer, and micron-sized baking soda powder in a certain proportion, stir and dissolve, and obtain the liquid embolism HW02 of the present invention. (The amount of sulfonation is half that of HW01)

Embodiment 3

[0030] Example 3 5g of EVOH polymer was heated and stirred with 30mL of N-methylpyrrolidone to dissolve, the sulfonating agent used was 5g of chlorosulfonic acid, and a small amount of about 0.01g of silver sulfate was added as a catalyst to accelerate the reaction. After heating and stirring at 70°C for 2 hours, the mixture was cooled at room temperature. Pour the cooled copolymer into 200mL-300mL methanol to make it precipitate, take the precipitate and add 25mL N-methylpyrrolidone to redissolve it, add 200mL-300mL methanol to make it precipitate again, repeat this several times, and finally remove the precipitate things dry. Or use vacuum drying. Mix the finally obtained sulfonated modified EVOH copolymer, N-methylpyrrolidone, Ta powder developer, and micron-sized baking soda powder in a certain proportion, stir and dissolve, and obtain the liquid embolism agent HW03 of the present invention.

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Abstract

The invention discloses a sodium bicarbonate powder-loaded liquid embolizing agent composition and a purpose thereof. The liquid embolizing agent is composed of an anion-modified polyethylene polyvinyl alcohol copolymer (EVOH), a solvent, sodium bicarbonate powder, and a developer according to certain proportions. negative ions groups are introduced on a high molecular chain through chemical modification or grafting modification by EVOH, and the negative ions groups are capable of performing adsorption loading on a cationized chemotherapeutic anti-cancer medicine through interacting of positive and negative charges. A solvent can be dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidinone (NMP), ethanol or a mixture. A developer is micron metal tantalum powder or an iodine-containing contrast agent or a mixture of the micron metal tantalum powder and the iodine-containing contrast agent. The sodium bicarbonate is capable of sensitizing ischemic effect of tumor cells, and increases the embolism curative effect. The liquid embolizing agent can be widely used for interveneing the embolism treatment, and is especially suitable for liver cancer through artery chemotherapy embolism treatment(TACE).

Description

technical field [0001] The invention relates to a liquid embolism composition loaded with sodium bicarbonate powder and an application thereof. The liquid embolism composition is mainly used in the interventional preparation of medicines for treating tumor diseases. It is especially suitable for preparing medicines for TACE treatment of liver cancer. Background technique: [0002] TACE, Trans Arterial Chemo Embolization (Trans Arterial Chemo Embolization) was first proposed by Japanese scholar Yamada in 1997. It was first used in the treatment of liver cancer, and now it has become the mainstream treatment method that more than 90% of liver cancer patients in the middle and late stages will choose. It refers to the targeted perfusion of embolic agents to tumor lesions through the femoral artery, abdominal aorta, and hepatic aorta using microcatheters under X-rays. The embolization agent blocks the blood supply artery of the tumor. After the blood supply of the tumor tissu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/02A61L24/06A61L24/02A61L24/00A61K47/32A61K47/02A61K47/22A61K31/704A61P35/00
CPCA61K31/704A61K47/02A61K47/22A61K47/32A61L24/001A61L24/0015A61L24/02A61L24/06A61L2300/416A61L2300/602C08L29/04
Inventor 徐平
Owner 杭州华微医疗科技有限公司
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