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Luminal B type HER-2 negative breast cancer prognostic prediction model KLP-PI

A KLP-PI, HER-2 technology, applied in health index calculation, medical automatic diagnosis, medical informatics, etc., can solve the problem of limited identification ability of Chinese people, and achieve the effect of high accuracy and good identification ability

Inactive Publication Date: 2018-07-20
王莹豪
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Problems solved by technology

The existing breast cancer prognosis prediction model is calculated from the data of foreign populations, but its ability to distinguish Chinese populations is limited

Method used

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  • Luminal B type HER-2 negative breast cancer prognostic prediction model KLP-PI

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specific Embodiment approach

[0011] Such as figure 1 As shown, the luminal B type HER-2 negative breast cancer prognosis prediction model KLP-PI is calculated based on the Chinese population model KLP-PI:

[0012] KLP-PI=1.0*KI-67LI+1.5*LN+1*PR status, according to tumor KI-67 proliferation index, if it is greater than 30%, KI-67LI is assigned a value of 1, and if it is less than 30%, KI-67LI is assigned a value of 0, LN represents the status of lymph node metastasis. If there is metastasis, it is assigned a value of 1. If there is no transfer, it is assigned a value of 0. PR status represents the status of progesterone receptor. If it is positive, it is 0, and if it is negative, it is 1. The KLP-PI value is divided into three groups. 0-1.5 is divided into low-risk group, 2-2.5 is divided into medium-risk group, and 3.5 is divided into high-risk group.

[0013] The luminal B type HER-2 negative breast cancer prognosis prediction model KLP-PI compared to the NPI index, the luminal B type HER-2 negative br...

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Abstract

The invention discloses a luminal B type HER-2 negative breast cancer prognostic prediction model KLP-PI and relates to the field of COX algorithm prognostic prediction. The luminal B type HER-2 negative breast cancer prognostic prediction model KLP-PI is obtained based on the Chinese population. KLP-PI=1.0*KI-67LI+1.5*LN+1*PR status, according to a tumor KI-67 proliferation index, KI-67 LI is assigned with a value of 1 if the tumor KI-67 proliferation index is larger than 30%, the KI-67 LI is assigned with a value of 0 if the tumor KI-67 proliferation index is smaller than 30%, LN representslymph node metastasis, the LN is assigned with a value of 1 if the metastasis exists and is assigned with a value of 0 if the metastasis does exist, PR status represents the condition of a progesterone receptor, the PR status is 0 for a positive condition and is 1 for a negative condition, a results KLP-PI value is divided into three groups, scores 0 to 1.5 are in a low-risk group, scores 2 to 2.5are in a medium-risk group, and scores 3 to 5 is in a high-risk group.

Description

technical field [0001] The invention relates to the field of COX algorithm prognosis prediction, in particular to a luminal type B HER-2 negative breast cancer prognosis prediction model KLP-PI. Background technique [0002] Luminal B breast cancer is divided into two types, one is ER and (or) PR positive, HER-2 gene negative, Ki67 cell proliferation index is highly expressed (≥14%), and the other is ER and (or) PR positive, HER-2 gene negative -2 gene positive regardless of Ki67 proliferation index. This type of breast cancer accounts for 20%-30% of all breast cancers, lacks targeted drugs, and 10-30% relapses and metastasizes. Therefore, a model that can predict the prognosis of this type of breast cancer is needed. There is a Nottingham Prognostic Index (NPI), which is based on tumor size, lymph node metastasis, and tumor grade. NPI=(0.2*S)+N-G (S represents the tumor size, in centimeters; N represents the number of lymph node metastases, 0 lymph nodes, N is 1, 1-4 lymp...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16H50/20
Inventor 王瓯晨王莹豪潘传孟
Owner 王莹豪
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