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Application of andrographolide compound in preparation of medicine for radiation injury

An ester compound, radiation damage technology, applied in the field of drug application, can solve the problem of no literature report on the use of radiation damage drugs and so on

Pending Publication Date: 2018-08-14
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In summary, andrographolide compounds have a wide range of uses, mainly in antiviral, anti-inflammatory, antibacterial, antitussive and immune-enhancing aspects, but there is no literature report on the use of radiation-damaged drugs

Method used

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  • Application of andrographolide compound in preparation of medicine for radiation injury
  • Application of andrographolide compound in preparation of medicine for radiation injury
  • Application of andrographolide compound in preparation of medicine for radiation injury

Examples

Experimental program
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Embodiment 1

[0105] 1. Modeling method

[0106] Female (20g) C57 / BL6 mice were intraperitoneally injected with 1% sodium pentobarbital, fixed in self-made plexiglass mouse cages after anesthesia, arranged in turn on the treatment bed, and collectively irradiated 10 mice at a time. Use a 6MV-X-ray linear accelerator for a single whole-thorax irradiation (both lungs of mice) 18Gy, absorption metering rate 200cGy / min, SSD=100cm, irradiation field 30cm X1.8cm, 1.8cm is the distance from the neck to the chest of the mouse (Such as figure 1 ). After the irradiation, the mice were reared routinely.

[0107] The mice in the blank control group had no obvious abnormal symptoms during the experiment. In the 7th week after irradiation, the mice in the simple irradiation group began to appear listless, their diet and activities decreased, their weight did not increase, their feces were dry and hard, their fur in the chest irradiation field began to turn white, and some mice experienced hair loss in...

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PUM

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Abstract

The invention discloses an application of an andrographolide compound in preparation of a medicine for radiation injury. The andrographolide compound comprises the andrographolide compound, its isomer, a prodrug, a solvate or pharmaceutically acceptable salt; The andrographolide compound has good effect for treating radiation injury.

Description

technical field [0001] The invention relates to the field of pharmaceutical application, in particular to the application of an andrographolide compound and its isomer, prodrug, solvate or pharmaceutically acceptable salt in the preparation of radiation damage medicine. Background technique [0002] There is no doubt that radiotherapy plays a significant role in the treatment of malignant tumors, but the existence of radiation reactions and damage should also be seen. High-dose radiation kills cancer cells and damages normal cells at the same time, and patients will experience certain adverse reactions. Radiation therapy can only kill tumor cells to the maximum extent that normal tissues can tolerate. For radiation-sensitive tumors, the dose to kill cancer cells will not damage the normal tissues around the tumor. Radiation therapy can cure the tumor, but the lethal dose of radiation to some tumor cells is similar to the lethal or damaging dose to surrounding normal tissue ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/585A61K31/255A61P29/00A61P39/00A61P17/16
CPCA61K31/255A61K31/365A61K31/585
Inventor 陈晓蒋春红范海伟程玲曾君南王章伟张功俊
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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