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A Personalized Prognostic Assessment Method for Pancreatic Cancer Based on Multiple Gene Expression Profiles

A technique for expression signature, prognostic assessment with applications in biotechnology and medicine

Active Publication Date: 2022-04-15
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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Problems solved by technology

However, most reports only use single or several genes, can only classify a group, and can only qualitatively divide the individual survival period (such as two indicators of good prognosis and poor prognosis)

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  • A Personalized Prognostic Assessment Method for Pancreatic Cancer Based on Multiple Gene Expression Profiles
  • A Personalized Prognostic Assessment Method for Pancreatic Cancer Based on Multiple Gene Expression Profiles
  • A Personalized Prognostic Assessment Method for Pancreatic Cancer Based on Multiple Gene Expression Profiles

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Embodiment Construction

[0063] The embodiments of the present invention will be described in detail below, whereby the implementation process of how to apply technical problems to solve technical problems and achieve technical effects.

[0064] The present invention discloses a personalized prognostic method of pancreatic cancer based on a polymeric expression character spectrum, including the steps of:

[0065] Step 1, obtain the list of rispies and gene weights, specifically:

[0066] Step 1.1, from the Genomic Data Commons Data Portal database download pancreatic cancer tumor tissue and cancer tissue transcription group data and clinical data, obtaining tumor tissue gene expression spectrum FPKM in patients with pancreatic cancer ( F ragments P ER K Ilobase of Transcript Per M Illion fragments mapped) value for logarithmic conversion (log2).

[0067] Step 1.2, the total sample number is M, divide all samples into three groups according to the three-point number of its gene expression value, where the ...

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Abstract

The invention discloses a method for evaluating the individualized prognosis of pancreatic cancer based on a multi-gene expression profile, which comprises the following steps: obtaining a list of prognostic risk genes and gene weights for pancreatic cancer; constructing a prognosis evaluation using tumor tissue transcriptome and survival data of pancreatic cancer patients Model; calculate the patient's risk score based on the gene expression profile of the tumor tissue of pancreatic cancer patients; calculate the patient's annual survival probability based on the patient's risk score. The annual survival probability of patients with pancreatic cancer obtained by the method of the present invention is highly consistent with the actual annual survival ratio (linear correlation R 2 = 0.980, P-value = 9.76E‑17). It is confirmed that the method has high prediction accuracy, which is highly consistent with the actual survival status. At the same time, for each tumor patient, the present invention can provide the specific survival probability curve of the patient.

Description

Technical field [0001] The present invention belongs to the field of biotechnology and medicine, and in particular, the present invention relates to a personalized prognostic evaluation method of pancreatic cancer based on polymeric expression characteristics. Background technique [0002] Pancreatic cancer is a malignant tumor that is harmful in global. Patients with pancreatic cancer are usually only shorter average survival. Statistics show that the number of deaths in male patients with pancreatic cancer in global scope is small. Global Burden Of Disease (GBD) data shows that the number of people with pancreatic cancer in 2016 is 360,000, of which China's patient is 57,000. The number of deaths in patients with global pancreatic cancer in 2016 is 410,000, accounting for 0.74% of the total death. China's 2016 death patients exceeded 72,000, accounting for 0.74% of the total death. The statistical results show that the risk of global pancreatic cancer has continued to grow from...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H50/30G16B40/00G16B5/00G16B20/00
CPCG16B5/00G16B20/00G16B40/00G16H50/30
Inventor 李功华李文兴黄京飞赵旭东代绍兴
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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