DAI (diffuse axonal injury) causing device and experiment method

Abstract

The invention provides a DAI causing device and an experiment method, the DAI causing device comprises a striking platform, a linear striking injury part and a rotation angle acceleration and deceleration injury part, wherein the striking platform is used for placing an experiment animal; the linear striking injury part comprises a striking rod and a locking device, when the linear striking injurypart works, the locking device loosens a connection rope, and the striking rod falls freely and strikes the experiment animal on the striking platform; the rotation angle acceleration and deceleration injury part comprises a spindle, a rotating plate, a driving spring, a blocking ratchet rod and a push-and-pull part, the push-and-pull part can push or pull the blocking ratchet rod so that the blocking ratchet rod can break away from a tooth-shaped clamping groove of the rotating plate, the rotating plate rotates under the torsion action of the driving spring, the spindle is driven to rotate,and further the striking platform is driven to rotate. The DAI causing device and the experiment method have the advantages that linear acceleration injury and rotation acceleration injury can be combined, the parameters can be adjusted, and different levels of brain injuries are copied.

Description

technical field [0001] The invention relates to the field of medical diagnosis research, in particular to a diffuse axonal injury injury device and an experimental method. Background technique [0002] Diffuse axonal injury: (Diffuse axonal injury, DAI): refers to a primary brain parenchymal injury that occurs after trauma to the head, and is mainly diffusely distributed in the white matter of the brain, with axonal injury as the main change. Its characteristics are: (1) extensive white matter degeneration, small focal hemorrhage; (2) axonal retraction balls, microglial clusters appear; (3) often combined with other craniocerebral injuries, high mortality. With the improvement of pathological diagnosis technology, the establishment of various animal models and the improvement of high-resolution and high-definition imaging technology have provided powerful help for the diagnosis and treatment of this disease. At present, the understanding of the pathogenesis of DAI is basica...

AI Technical Summary

Problems solved by technology

However, the mechanical parameters of the existing animal model injury devices at home and abroad are mostly fixed (non-adjustable), which can only simulate one severity of DAI, and the same model cannot reproduce DAI with different damage levels by adjusting the parameters. Limits us to study DAI more comprehensively

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