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Application of chlamydia muridarum in preparation of anti-ulcerative colitis drugs

A murine chlamydia, anti-ulcer technology, applied in the field of biomedicine, can solve problems such as rare digestive system

Active Publication Date: 2018-11-16
NANHUA UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the research on chlamydia mainly focuses on its pathogenicity, especially the research on the urogenital tract and respiratory system, but the research on the digestive system is very rare, and the effect of chlamydia on the intestinal tract and related molecular mechanisms are rarely related Literature report

Method used

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  • Application of chlamydia muridarum in preparation of anti-ulcerative colitis drugs
  • Application of chlamydia muridarum in preparation of anti-ulcerative colitis drugs
  • Application of chlamydia muridarum in preparation of anti-ulcerative colitis drugs

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] 1. Chlamydia murine has anti-ulcerative colitis effect

[0016] (1) Growth of Chlamydia murine (CM) in the intestinal tract of C57BL / 6J wild-type mice (Table 1)

[0017] Table 1. Growth of CM in the intestine of wild-type mice (log10 )

[0018]

[0019] Note: ND means not detected

[0020] After Chlamydia murine infects C57BL / 6J wild-type mice by intragastric administration, the anus test was used to detect the growth of the intestinal lingloplasma. The results of IFA showed that the growth of Chlamydia in the intestines of wild-type mice was relatively stable. The role of anti-ulcerative colitis lays the groundwork.

[0021] (2) Chlamydia murine (CM) inhibited DSS-induced weight loss in C57BL / 6J wild-type mice ( figure 1 )

[0022] Wild-type murine Chlamydia (G13.32.1) was intragastrically infected (intragastric infection, i.g.) C57BL / 6J wild-type mice were given 3.5% DSS drinking water at 29 days after infection, and continued for 5 days. The results showed t...

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Abstract

Experiments indicate that chlamydia muridarum (CM) can antagonize wild mice ulcerative colitis induced by dextran sulfate sodium (DSS), suggest that the CM has anti-ulcerative colitis effect, and theCM can be used for preparing anti-ulcerative colitis drugs.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of murine chlamydia in the preparation of anti-ulcerative colitis medicine. Background technique [0002] Inflammatory bowel disease (Inflammatory Bowel Disease, IBD) is a common chronic inflammatory disease of the digestive system. Its clinical symptoms mainly include abdominal pain, diarrhea, and blood in the stool, and extraintestinal clinical manifestations such as skin, joints, eyes, bones, and liver and bile ducts often occur. The pathogenesis of IBD is complex, with multiple stages of pathogenesis, unclear etiology, easy recurrence, easy cancer and difficult to cure, so it is listed by the World Health Organization as one of the modern intractable diseases. Epidemiological surveys found that the incidence of the disease has been increasing year by year in recent years, which seriously endangers people's health and quality of life. Although ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61P1/04
CPCA61K35/74A61P1/04
Inventor 贺庆芝
Owner NANHUA UNIV
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