Microbiota and applications for oral cancer risk prediction

A microbiome and risk prediction technology, applied in the direction of microbial determination/inspection, biochemical equipment and methods, etc., can solve problems such as predicting oral cancer risk, and achieve the effect of predicting oral cancer risk, improving convenience, and non-invasive detection process.

Active Publication Date: 2022-06-28
GENETALKS BIO TECH CHANGSHA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing technology does not clarify how to predict oral cancer risk by microbiome profile

Method used

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  • Microbiota and applications for oral cancer risk prediction
  • Microbiota and applications for oral cancer risk prediction
  • Microbiota and applications for oral cancer risk prediction

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Embodiment Construction

[0033] Based on the analysis of the sequencing data of 127 healthy controls and 125 oral cancer saliva samples, the inventors identified the flora classification markers; the distribution of microbial bacteria in the population is as follows: figure 1shown. The details are as follows: healthy human enriched flora: g__Prevotella|s__melaninogenica, g__Rothia|s__mucilaginosa, g__Veillonella|s__parvula, p__TM7|c__TM7-3, f__Campylobacteraceae|g__Campylobacter, g__Rothia|s__aeria, c__TM7-3|o__CW040, f__Cardiobacteriaceae|g__Cardioobbacterium, g__Streptococus g__Propionibacterium|s__acnes、f__Moraxellaceae|g__Enhydrobacter、g__Vibrio|s__metschnikovii;口腔癌患者富集菌群:f__Carnobacteriaceae|g__Granulicatella、f__Prevotellaceae|g__Prevotella、g__Porphyromonas|s__endodontalis、g__Aggregatibacter|s__segnis、g__Selenomonas|s__noxia、f__Veillonellaceae|g__Dialister、f__Enterococcaceae|g__Vagococcus、p__GN02| c__BD1-5、o__Coriobacteriales|f__Coriobacteriaceae、c__Bacteroidia|o__Bacteroidales、f__Veillonellaceae...

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Abstract

The present invention discloses the microbiota for risk prediction of oral cancer and its application. Based on the analysis of sequencing data of a total of 127 healthy controls and 125 oral cancer saliva samples, the inventors identified the microbial group classification markers. Based on the microbiota of the present invention, the risk of oral cancer can be effectively predicted. The diagnostic reagent developed based on the microbiota of the present invention can effectively predict the risk of oral cancer, and the detection process is non-invasive and has high safety. At the same time, because the flora samples can be transported at room temperature, the convenience of detection is greatly improved.

Description

technical field [0001] The present invention relates to the application of markers and related reagents for predicting oral cancer risk prediction. Background technique [0002] Oral cancer is one of the most common cancers, of which more than 80% are oral squamous cell carcinoma. There are many factors that affect the incidence of oral cancer, including smoking, drinking, viral infection, etc. About 300,000 people suffer from oral cancer every year. The incidence of oral cancer is a gradual process, and it is often overlooked in the early stage, which delays the best time for treatment. At present, the gold standard for the diagnosis of oral cancer is still through pathological diagnosis. Therefore, it is necessary to develop new specific diagnostic molecular targets. of. [0003] Some studies have been conducted on the relationship between oral flora and oral cancer, such as: [0004] Xu Yunlong, Yu Jinhua. Changes of microorganisms in the oral cancer area[J]. Oral Biome...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886
Inventor 宋卓卢秦孙海鹏
Owner GENETALKS BIO TECH CHANGSHA CO LTD
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