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Kit for detecting obesity risk and application thereof

A kit and obesity technology, which is applied in the application field of microbial flora analysis, can solve problems such as the unsatisfactory accuracy of obesity risk, and achieve the effects of predicting obesity risk, improving convenience, and high safety

Inactive Publication Date: 2019-03-19
GENETALKS BIO TECH CHANGSHA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing technology is not very accurate in predicting the risk of obesity through the condition of the microbiome

Method used

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  • Kit for detecting obesity risk and application thereof
  • Kit for detecting obesity risk and application thereof
  • Kit for detecting obesity risk and application thereof

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Embodiment Construction

[0037] Based on the analysis of the sequencing data of a total of 156 healthy controls and 66 obese stool samples, the inventor identified the markers for the classification of flora, and the distribution of microbial bacteria in the population is as follows: figure 1 shown. 具体如下:健康人富集菌群:f__Prevotellaceae|g__Prevotella|s__stercorea、g__Bacteroides|s__plebeius;肥胖人群富集菌:f__Lachnospiraceae|g__Roseburia、o__Clostridiales|f__Mogibacteriaceae、g__Gemella|f__Gemellaceae、f__Lachnospiraceae|g__Blautia、f__Coriobacteriaceae|g__Eggerthella|s__lenta、o__Lactobacillales| f__Leuconostocaceae、f__Ruminococcaceae|g__Oscillospira、f__Clostridiaceae|g__Clostridium、f__Streptococcaceae|g__Streptococcus、o__Coriobacteriales|f__Coriobacteriaceae、f__Porphyromonadaceae|g__Parabacteroides、f__Tissierellaceae|g__Finegoldia、f__Campylobacteraceae|g__Campylobacter、f__Lachnospiraceae|g__Dorea、f__Eubacteriaceae|g__Pseudoramibacter_Eubacterium、f__Tissierellaceae|g__Peptoniphilus。

[0038] Table 1 shows the enrichment o...

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Abstract

The invention belongs to the application field of microbial flora analysis, and particularly relates to a kit for detecting the obesity risk and application thereof. The OUT sequence amplified by thekit is as shown in the SEQ ID NO:1-SEQ ID NO:15. The invention further provides non-medical purpose application of the kit in obesity risk detection, the obesity risk is obtained by calculating floraabundance with a calculation formula as shown in the specification, wherein Ij is a risk index, Aij is the relative abundance of culture I in a sample j, N is a subset of an enriched flora selected from a health human flora, M is a subset of enriched flora related to obesity, and absolute values of N and M are respectively the number of cultures of the first and second subsets. According to the kit, the obesity risk is analyzed through the OUT sequence and flora abundance by selecting a specific microbial flora, along with high accuracy, small amount of flora to be analyzed, convenience and rapidness.

Description

technical field [0001] The invention belongs to the application field of microbial flora analysis, and in particular relates to a kit and application for detecting obesity risk. Background technique [0002] With the gradual acceleration of modern life rhythm, increasing pressure and rich material conditions, obesity is becoming an important health problem that plagues modern people, and obesity is showing a trend of younger people. Obesity is one of the important risk factors for type 2 diabetes and cardiovascular disease. At the same time, obesity will seriously affect personal image and cause corresponding social and psychological problems. However, the mechanism of obesity is still not clear enough. In addition to genetic factors In addition to socioenvironmental factors, current research shows that there is a strong relationship between gut microbiota and obesity. [0003] Some studies have been carried out on the relationship between intestinal flora and obesity, such...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6888C12Q1/06
CPCC12Q1/06C12Q1/6888Y02A50/30
Inventor 卢秦宋卓
Owner GENETALKS BIO TECH CHANGSHA CO LTD
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