Microbial flora and its application for risk prediction of oral precancerous lesions

A microbiota and risk prediction technology, applied in the direction of microorganism-based methods, microorganisms, and microbial measurement/testing, can solve the problems of predicting the risk of oral precancerous lesions and not being clear, so as to predict the risk of oral precancerous lesions and improve Convenience and high safety effect

Active Publication Date: 2022-06-28
GENETALKS BIO TECH CHANGSHA CO LTD
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Existing technology does not clarify how to predict the risk of oral precancerous lesions through the status of the microbiome

Method used

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  • Microbial flora and its application for risk prediction of oral precancerous lesions
  • Microbial flora and its application for risk prediction of oral precancerous lesions
  • Microbial flora and its application for risk prediction of oral precancerous lesions

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Embodiment Construction

[0053] Based on the analysis of the sequencing data of 127 healthy controls and 124 oral precancerous lesions, the inventors identified the bacterial classification markers, and the distribution of microbial bacteria in the population is as follows: figure 1 shown. details as follows:

[0054] The enriched flora of healthy people contains: p__Firmicutes|c__Bacilli|o__Lactobacillales,

[0055] f__Prevotellaceae|g__Prevotella|s__nanceiensis, f__Veillonellaceae|g__Megasphaera,

[0056] c__TM7-3|o__CW040, o__Clostridiales|f__Peptostreptococcaceae,

[0057] o__Rickettsiales|f__mitochondria, f__Tissierellaceae|g__WAL_1855D,

[0058] f__Staphylococcaceae|g__Staphylococcus, f__Tissierellaceae|g__ph2,

[0059] o__Campylobacterales|f__Helicobacteraceae, g__Paenibacillus|s__lautus;

[0060] The enriched flora of patients with oral precancerous lesions contains: f__Micrococcaceae|g__Rothia|s__dentocariosa,

[0061] f__Enterococcaceae|g__Vagococcus, f__Porphyromonadaceae|g__Paludibac...

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Abstract

The present invention discloses the microbiota and its application for the risk prediction of oral precancerous lesions. Based on the analysis of the sequencing data of a total of 127 healthy controls and 124 fecal samples of oral precancerous lesions, the inventor identified the classification markers of the flora thing. Based on the microbiota of the present invention, the risk of oral precancerous lesions can be effectively predicted. The diagnostic reagent developed based on the microbiota of the present invention can effectively predict the risk of oral precancerous lesions, and the detection process is non-invasive and has high safety. At the same time, because the flora samples can be transported at room temperature, the convenience of detection is greatly improved.

Description

technical field [0001] The present invention relates to microbial flora and application for risk prediction of oral precancerous lesions. Background technique [0002] Oral cancer is the most common head and neck malignancy, and the incidence of oral cancer has been on the rise in many countries in recent years. Oral cancer can develop from oral precancerous lesions such as oral leukoplakia. Oral precancerous lesions are precancerous lesions characterized by oral submucosal fibrosis and oral lichen planus and other oral mucosal changes. Precancerous lesions have large cancerous changes. Because of the lack of tumor biomarkers for early screening and detection, more than 50% of oral cancer patients can be diagnosed at an advanced stage, and the discovery of tumor markers that can be used for early diagnosis of oral cancer is becoming a research hotspot. [0003] Jiang Jingang, Yan Zhenqiu. Research status of markers of oral precancerous lesions[J].Journal of Clinical Militar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/689C12Q1/10C12Q1/06G16H50/30C12R1/145C12R1/265C12R1/425C12R1/01
CPCG16H50/30C12Q1/689
Inventor 宋卓卢秦孙海鹏
Owner GENETALKS BIO TECH CHANGSHA CO LTD
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