A product for evaluating the effect of propranolol in the treatment of infantile hemangioma
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A technology of infantile hemangioma and propranolol, applied in the field of medicine, can solve problems such as no breakthrough progress, and achieve the effect of promoting inhibitory effect
Active Publication Date: 2021-06-18
SHANDONG UNIV QILU HOSPITAL
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In summary, the emergence of PRO provides a certain opportunity for the study of the pathogenesis of IH, but there is still no breakthrough at this stage
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[0043] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the present invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
[0044] It should be noted that the terminology used here is only for describing specific embodiments, and is not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations and / or combinations thereof.
[0045] Aiming at the problems raised in the background technology, the present invention provides a product for evaluating the prognosis of infantile heman...
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Abstract
The invention belongs to the field of medicine, and in particular relates to a product for evaluating the effect of propranolol in treating infantile hemangioma. The product is a test kit, equipment, operable operating system and / or their combination, and the product includes: (1) reagents, instruments and / or systems for measuring the expression abundance of ID1 and β-actin in the cells of the subject (2) a module and / or processor for calculating the relative expression of ID1; (3) a module and / or processor for evaluating the therapeutic effect of propranolol on the object's infantile hemangioma according to the relative expression of ID1 . The present invention provides an effective evaluation method for early detection of whether infantile hemangioma patients have drug resistance to propranolol, and effectively evaluates the therapeutic effect of propranolol on infantile hemangioma. The evaluation method of the present invention Whether the patient is resistant to propranolol can be detected as early as possible, and the treatment plan can be adjusted in time, which is of great significance to the recovery of the patient.
Description
technical field [0001] The invention belongs to the field of medicine, and in particular relates to a product for evaluating the effect of propranolol in treating infantile hemangioma. Background technique [0002] Infantile hemangioma (Infantile Hemangiomas, IH) is a common vascular tumor of infants, the incidence rate of which is as high as 5-10% in ordinary infants, and rises to 30% in premature infants. The onset process is that punctate erythema appears on the skin within a few weeks after delivery, enters a rapid proliferation period, and spontaneously enters a regression period that lasts for several years after about one year of age (Kilcline, C., Frieden, I.J. (2008) Infantile hemangiomas: how common are they? A systematic review of the medical literature. Pediatr Dermatol. 25(2):168-173; Chang, L.C., Haggstrom, A.N., Drolet, B.A., Baselga, E., Chamlin, S.L., Garzon, M.C., Horii, K.A. , Lucky, A.W., Mancini, A.J., Metry, D.W., Nopper, A.J., Frieden, I.J. (2008) Gro...
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