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Application of detection of lnc_ENST00000319426.3 in blood in diagnosing gastric cancer staging

A gastric cancer and blood technology, applied in the field of tumor molecular biology, can solve the problems of large trauma and unacceptable patients, and achieve the effect of alleviating the pain of patients, avoiding excessive medical treatment, and saving medical resources.

Inactive Publication Date: 2019-04-19
江苏万成生物医学研究院有限公司
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  • Abstract
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Problems solved by technology

Evaluate the patient's condition by detecting tumor indicators such as CEA / CA199 / CA153 in the patient's blood, but the trauma is large and the patient is not easy to accept

Method used

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  • Application of detection of lnc_ENST00000319426.3 in blood in diagnosing gastric cancer staging
  • Application of detection of lnc_ENST00000319426.3 in blood in diagnosing gastric cancer staging
  • Application of detection of lnc_ENST00000319426.3 in blood in diagnosing gastric cancer staging

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Embodiment Construction

[0022] The present invention will be further explained below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the following specific embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0023] Such as Figure 1 to Figure 4 As shown, the present invention discloses the application of detecting lnc_ENST00000319426.3 in blood in the diagnosis of gastric cancer staging, and the nucleotide sequence of lnc_ENST00000319426.3 molecular marker is SEQ ID NO.1.

[0024] 1. Research materials

[0025] 1.1 Subjects of the experiment.

[0026] This study is based on the Department of General Surgery, Nanjing Hospital Affiliated to Nanjing Medical University. The Department of General Surgery treats GC patients all year round and establishes a specimen bank, which can provide rich case data for this study. The tissues and blood of the study patients came from GC ...

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Abstract

The invention discloses application of detection of lnc_ENST00000319426.3 in blood in diagnosing gastric cancer staging, and relates to discovery, detection and application of lnc_ENST00000319426.3. The nucleotide sequence of an lnc_ENST00000319426.3 molecular marker is SEQ ID NO.1. A specific detection primer for real-time quantification PCR is designed and synthesized. Lnc_ENST00000319426.3 in the blood can serve as a plasma marker for patients with gastric cancers. Application of lnc_ENST00000319426.3 is put forward, difference exists between the expression quantities of lnc_ENST00000319426.3 in blood samples of GC patients and normal people, and is related to staging, and therefore, lnc_ENST00000319426.3 has an application potential of GC biomarkers.

Description

technical field [0001] The invention relates to the field of tumor molecular biology, in particular to an application of detecting lnc_ENST00000319426.3 in blood in the diagnosis of gastric cancer staging. Background technique [0002] At present, gastric cancer still ranks third in cancer-related deaths worldwide and is one of the major health burdens of society. Gastric cancer is the second most prevalent cancer and the second leading cause of cancer death in China, with an estimated 679,100 new cases and 498,000 deaths in 2015. Despite advances in surgical techniques and combined chemotherapy regimens, the 5-year overall survival of gastric cancer is still below 30% in most countries because of the lack of early diagnostic markers for gastric cancer. Therefore, it is an important means to improve the curative effect and prognosis of GC patients by continuously exploring the occurrence and development mechanism of GC and finding new molecular markers related to early diag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12Q1/6851C12N15/11
CPCC12Q1/6851C12Q1/6886C12Q2600/112C12Q2600/158C12Q2600/178C12Q2531/113C12Q2563/107
Inventor 康宁朱桂芳曹秀峰
Owner 江苏万成生物医学研究院有限公司
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