Duck adenovirus type-3 virus strain and yolk antibody preparation and application thereof

A technology of egg yolk antibody and adenovirus, applied in the direction of virus antigen components, virus/phage, antibody, etc., can solve the problems of inability to produce antibodies, low virus protection rate, and differences in clinical data, and achieve good specificity and immunogenicity , high immune protection rate and broad application prospects

Active Publication Date: 2019-08-13
GUANGDONG MAIKETE BIOLOGICAL TECH
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  • Abstract
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  • Claims
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Problems solved by technology

[0003] There is currently no effective prevention and control method for duck adenovirus type 3, but there are research reports on inactivated vaccines, but such vaccines are still in the scientific research stage and are still No successful reports and products produced
At the same time, the existing research has the following problems: First, the infection model design is unreasonable. Ducks infected with the virus did not show typical symptoms, the virus was not detected in various tissues, and the ducks did not show death symptoms, which was different from the clinical data; It is becaus

Method used

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  • Duck adenovirus type-3 virus strain and yolk antibody preparation and application thereof
  • Duck adenovirus type-3 virus strain and yolk antibody preparation and application thereof
  • Duck adenovirus type-3 virus strain and yolk antibody preparation and application thereof

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Embodiment Construction

[0022] A duck adenovirus type 3 GD06 virus strain, the duck adenovirus type 3 GD06 virus strain was deposited in the China Type Culture Collection on January 31, 2019, the deposit number is CCTCC NO: V201905, and the classification is named duck gland Virus type 3 GD06 strain.

[0023] Preferably, the nucleotide sequence of the Hexon gene of the virus strain is shown in SEQ ID NO.1.

[0024] The application of the duck adenovirus type 3 GD06 strain described above in the preparation of duck adenovirus type 3 vaccine.

[0025] Preferably, the duck adenovirus type 3 vaccine is a whole virus inactivated vaccine.

[0026] A method for constructing an animal model of adenovirus infection, comprising: injecting the duck adenovirus type 3 GD06 virus strain as described above into an animal to cause the animal to develop disease; preferably, the animal is a poultry; more preferably , The animal is a Muscovy duck.

[0027] A duck adenovirus type 3 inactivated vaccine, the inactivated vaccine i...

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Abstract

The invention discloses a duck adenovirus type-3 virus strain and yolk antibody preparation and application thereof. The duck adenovirus type-3 virus strain is produced by a duck adenovirus type-3 virus GD06 strain immune poultry with the preservation number being CCTCC NO:V201905. The virus strain has the good specificity and immunogenicity. The yolk antibody of the adenovirus type-3 is high in safety, infection of the duck adenovirus type-3 is effectively prevented, the immunity protecting rate is high, and the duck adenovirus type-3 is effectively treated; the virus strain can be used for detecting duck adenovirus type-3 virus and has the wide application prospect.

Description

Technical field [0001] The invention belongs to the field of animal antigen and antibody, in particular the preparation and application of a duck adenovirus type 3 virus strain and its egg yolk antibody. Background technique [0002] Fowl adenovirus is a common infectious disease of poultry and wild fowl. In recent years, duck adenovirus type 3 (DAdV-3) has spread widely in my country. After being infected with duck adenovirus type 3, muscovy ducks will have liver enlargement, paleness, splenomegaly, congestion and other symptoms. The mortality rate of this disease can reach more than 50%, causing huge losses to the duck industry. In recent years, the prevalence of duck adenovirus type 3 has shown an outbreak trend, seriously jeopardizing the development of the duck industry. [0003] Duck adenovirus type 3 currently has no effective prevention and control methods, but there are research reports on inactivated vaccines. However, such vaccines are still in the scientific research ...

Claims

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Application Information

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IPC IPC(8): C12N7/00A61K39/235A61P31/20A01K67/027C07K16/08C07K16/02A61K39/42C12R1/93
CPCC12N7/00A61K39/12A61P31/20A01K67/027C07K16/081C12N2710/10221C12N2710/10234A61K2039/5252A61K2039/552A01K2207/20A01K2227/30A01K2267/0337C07K2317/11A61K2039/505
Inventor 江县良黄立平丘军辉张秀平
Owner GUANGDONG MAIKETE BIOLOGICAL TECH
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