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Synthesis method of visual guided tumor combined immunotherapy nano-preparation for Gd:CuS mineralized influenza virus (Flu@Gd:CuS)

A technology for influenza virus and immunotherapy, which is applied in the field of synthesis of Gd:CuS mineralized influenza virus visualization-guided tumor combined immunotherapy nano-preparation, which can solve the problems of harsh environmental requirements, cumbersome process, pollution, etc., and achieve no side effects, Excellent biocompatibility and high photothermal conversion efficiency

Pending Publication Date: 2019-08-30
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This technology allows for better ability to image tissue with both thermal treatment (T1WO) and photothermal ablation techniques. It also improves upon existing methods by providing more efficient light energy transfer from visible or infared rays into heat that helps treat cancer cells effectively without causing damage during surgery. Additionally it provides good biological compatibility while minimizing any negative reactions caused by its use.

Problems solved by technology

Technological Problem addressed in this patents relates to improving the efficacy of chemoimmunity or photothermal therapies used alone against specific types of disease such as lung cancer through activation of their innate immunesystem activity without harmful side effects or environmental concerns associated with current technologies like chemical agents.

Method used

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  • Synthesis method of visual guided tumor combined immunotherapy nano-preparation for Gd:CuS mineralized influenza virus (Flu@Gd:CuS)
  • Synthesis method of visual guided tumor combined immunotherapy nano-preparation for Gd:CuS mineralized influenza virus (Flu@Gd:CuS)

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Experimental program
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Effect test

Embodiment 1

[0020] The synthesis method of Flu@Gd:CuS tumor combined immunotherapy nano-preparation, the specific steps are as follows:

[0021] (1) Weigh 4.25 mg of copper chloride dihydrate (CuCl 2 ·2H 2 O) powder, ultrasonically dissolved after adding 5mL of ultrapure water, to obtain CuCl with a concentration of 0.005M 2 ·2H 2 O aqueous solution.

[0022] (2) Weigh 9.3 mg of gadolinium chloride hexahydrate powder (GdCl 3 ·6H 2 O), ultrasonically dissolved after adding 1mL ultrapure water, the concentration of GdCl obtained was 0.025M 3 ·6H 2 O aqueous solution.

[0023] (3) The method of synthesizing Flu@Gd:CuS nanoparticles by one-pot method: put a one-mouth bottle containing 2.5ml of influenza virus solution with a concentration of 0.005mg / ml on a magnetic stirrer in a water bath at 37°C, and then stir Under the condition, use a disposable dropper to drop the CuCl in the above configuration 2 ·2H 2 O and GdCl 3 ·6H 2 O solution, after dropwise addition, continue to stir ...

Embodiment 2

[0028] The synthesis method of Flu@Gd:CuS tumor combined immunotherapy nano-preparation, the specific steps are as follows:

[0029] (1) Weigh 8.5 mg of copper chloride dihydrate (CuCl 2 ·2H 2 O) powder, ultrasonically dissolved after adding 5mL of ultrapure water, to obtain CuCl with a concentration of 0.01M 2 ·2H 2 O aqueous solution.

[0030] (2) Weigh 18.6 mg of gadolinium chloride hexahydrate powder (GdCl 3 ·6H 2 O), ultrasonically dissolved after adding 1mL of ultrapure water to obtain GdCl with a concentration of 0.05M 3 ·6H 2 O aqueous solution.

[0031] (3) The method of synthesizing Flu@Gd:CuS nanoparticles by one-pot method: put a one-mouth bottle containing 5ml of influenza virus solution with a concentration of 0.01mg / ml on a magnetic stirrer in a water bath at 37°C, and then Next, use a disposable dropper to drop the CuCl in the above configuration 2 ·2H 2 O and GdCl 3 ·6H 2 O solution, after dropwise addition, continue to stir for three minutes;

[...

Embodiment 3

[0036] The synthesis method of Flu@Gd:CuS nanometer therapeutic agent, the specific steps are as follows:

[0037] (1) Weigh 17mg of copper chloride dihydrate (CuCl 2 ·2H 2O) powder, ultrasonically dissolved after adding 5mL ultrapure water, to obtain CuCl with a concentration of 0.02M 2 2H 2 O aqueous solution.

[0038] (2) Weigh 37.2 mg of gadolinium chloride hexahydrate powder (GdCl 3 ·6H 2 O), ultrasonically dissolved after adding 1mL ultrapure water, to obtain GdCl with a concentration of 0.1M 3 ·6H 2 O aqueous solution.

[0039] (3) The method of synthesizing Flu@Gd:CuS nanoparticles by one-pot method: put a one-mouth bottle containing 10ml of influenza virus solution with a concentration of 0.02mg / ml on a magnetic stirrer in a water bath at 37°C, and then Next, use a disposable dropper to drop the CuCl in the above configuration 2 2H 2 O and GdCl 3 ·6H 2 O solution, after dropwise addition, continue to stir for three minutes;

[0040] (4) Configure a sodium...

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Abstract

The invention discloses a synthesis method of a visual guided tumor combined immunotherapy nano-preparation for Gd:CuS mineralized influenza virus (Flu@Gd:CuS) and discloses a method for successfullysynthesizing the tumor combined therapy nano-preparation by strategy bionic simulation of Flu@Gd:CuS. The method comprises the main steps as follows: 1) preparation of a CuC12.2H2O aqueous solution; 2) preparation of a GdC13.6H2o aqueous solution; 3) synthesis of Flu@Gd:CuS nanoparticles by a one-pot method. Influenza virus structure is complex, the organism immune function of the whole body can be activated, and all-around killing and clearing of tumor can be realized. The Flu@Gd:CuS nanoparticles have significant T1 weighed magnetic resonance/opto-acoustic dual-mode imaging capacity, have higher photo-thermal conversion efficiency when exposed to near infrared laser, can efficiently guide following tumor photo-thermal therapy, have excellent biocompatibility and have no side effects.

Description

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Claims

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Application Information

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Owner TIANJIN UNIV
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