Durian peel polysaccharide, its extraction method and its application in the preparation of drugs for regulating intestinal flora and/or treating functional constipation

A technology for regulating intestinal flora and functional constipation, applied in the directions of drug combination, pharmaceutical formula, organic active ingredients, etc., can solve the problems of poor curative effect, toxic and side effects, and achieve the effect of significant curative effect and no toxic and side effects

Active Publication Date: 2021-06-01
HENAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the drugs used to treat functional constipation on the market have defects such as poor curative effect and toxic side effects.

Method used

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  • Durian peel polysaccharide, its extraction method and its application in the preparation of drugs for regulating intestinal flora and/or treating functional constipation
  • Durian peel polysaccharide, its extraction method and its application in the preparation of drugs for regulating intestinal flora and/or treating functional constipation
  • Durian peel polysaccharide, its extraction method and its application in the preparation of drugs for regulating intestinal flora and/or treating functional constipation

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Embodiment 1

[0020] A method for extracting polysaccharides from durian skin, specifically: take 4.2 kg of dried durian skin, add water until the durian skin is submerged, and decoct three times with water (boiling water temperature is 80-85°C, decocting for 2 hours for the first time, decocting for the second time) Boil for 1 h, decoct for the third time for 0.5 h). Combine the filtrates, concentrate under reduced pressure, add 95% ethanol to the concentrated solution until the final concentration of ethanol is 75%, leave it in the refrigerator overnight (12 h), centrifuge, collect the precipitate, and use the Sevage method to remove the protein after the precipitate is dissolved in water (choose volume ratio It is 4:1 chloroform-n-butanol mixture, and conventional techniques in this field can be used). Add 95% ethanol to the supernatant to a final concentration of 70%, let it stand in the refrigerator overnight (12h), rinse the precipitate with acetone, petroleum ether, and absolute etha...

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Abstract

The invention discloses a method for extracting polysaccharides from durian skin that regulates intestinal flora. Specifically, the durian skin is decocted with water, filtered, and the filtrate is added with 95% ethanol to a final concentration of 70±5%, left to stand, and the precipitate is collected and dissolved in water. After the Sevage method to remove the protein, take the supernatant and add 95% ethanol to the final concentration of 70±5%, let it stand, the precipitate is washed and freeze-dried to obtain the durian skin polysaccharide. The invention also discloses the application of durian skin polysaccharide in the preparation of medicine for treating functional constipation. The present invention finds through experiments that durian skin polysaccharide can significantly increase the content of motilin (MTL), gastrin (GAS), and substance P in serum and significantly reduce the content of somatostatin (SS); after continuous administration, it can significantly increase Relative abundance of Lachnospiraceae‑NK4A136‑group in the gut, decreased relative abundance of Desulfovibrio, increased defecation volume and intestinal motility rate, and improved functional constipation. Description: Durian skin polysaccharide is an ideal drug for regulating intestinal flora and treating functional constipation.

Description

technical field [0001] The invention belongs to the technical field of polysaccharide medicines, and in particular relates to a method for extracting polysaccharides from durian skin and its application in the preparation of medicines for treating functional constipation. Background technique [0002] Functional constipation (functional constipation, FC) is a functional disease, which refers to a functional gastrointestinal disease whose symptoms originate in the middle and lower gastrointestinal tract. Constipation caused by factors such as bad living habits, social and psychological effects, drug effects, etc. Constipation is functional constipation. Its clinical manifestations are difficult defecation, decreased frequency, prolonged defecation time, etc. Constipation has a great impact on the quality of life of patients. [0003] Epidemiological studies have shown that the high prevalence of chronic constipation is related to age, and women are higher than men, followed...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61P1/00A61P1/10
CPCA61K31/715A61P1/00A61P1/10C08B37/00C08B37/0003
Inventor 康文艺王金梅马常阳刘振花魏金凤崔丽丽姜慧敏梁振华
Owner HENAN UNIVERSITY
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