Adhesive hydrogel and preparation method thereof

A technology of hydrogel and cationic monomer, applied in the field of adhesive hydrogel and its preparation, can solve the problems of complex process, unfavorable adhesion, hard gel texture, etc., achieve mild conditions, avoid gel toxicity, improve The effect of adhesion strength

Active Publication Date: 2021-03-16
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, the polyion complex gels in the prior art are often prepared by a "two-step method" (cationic monomers and anionic monomers are polymerized separately in sequence), and the process is relatively complicated; and the resulting gel texture is relatively hard, which is not conducive to It adheres firmly to irregular solid surfaces

Method used

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  • Adhesive hydrogel and preparation method thereof
  • Adhesive hydrogel and preparation method thereof
  • Adhesive hydrogel and preparation method thereof

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preparation example Construction

[0039] The embodiment of the present invention proposes a method for preparing an adhesive hydrogel, comprising the following steps:

[0040] (1) Mix cationic monomers, photoinitiators, anionic components, and water to obtain a precursor solution;

[0041] (2) Degassing the above-mentioned precursor solution;

[0042] (3) irradiating the precursor solution obtained in step (2) with ultraviolet light to initiate the polymerization of cationic monomers, and the produced cationic polymer interacts with anionic components to form an adhesive hydrogel;

[0043] Wherein, the anionic component includes glycosaminoglycan and its derivatives.

[0044] The embodiment of the present invention adopts "one-step method" (homopolymerization of cationic monomers and electrostatic combination with short-chain anionic components) to prepare polyion composite hydrogels, which is different from the high The precursor solution of the charge concentration often leads to the hard texture of the pr...

Embodiment 1

[0073] Example 1 Preparation of Adhesive Hydrogels

[0074] 1) Prepare precursor solution: add acryloyloxyethyltrimethylammonium chloride (cationic monomer), ketoglutaric acid (photoinitiator), deionized water and sodium chondroitin sulfate (anionic component) to In the beaker, stir for 0.5h to obtain a uniform precursor solution.

[0075] Wherein, the total volume of the solution is 10ml, the concentration of the precursor solution is 2.5mol / L, the charge molar concentration ratio of the anion component and the cation component is 0.1, and the concentration of ketoglutaric acid is 0.1% of the concentration of the cationic monomer.

[0076] 2) Degassing of the precursor solution: place the prepared precursor solution in an ultrasonic cleaner, ultrasonically treat it for 1 hour at room temperature, then place the solution in a vacuum oven, and vacuum defoam for 0.5 hours at room temperature and -0.1MPa pressure , to obtain a bubble-free precursor solution.

[0077] 3) UV-in...

Embodiment 2-4

[0078] Example 2-4 Preparation of Adhesive Hydrogels

[0079] Same as Example 1, the difference lies in that in Examples 2-4, the molar concentration ratios of charges carried by the anion component and the cation component are 0.25, 0.5, and 1, respectively.

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Abstract

The invention provides adhesive hydrogel and a preparation method thereof, and relates to the field of polymer materials. The method comprises the following steps: (1) mixing a cationic monomer, a photoinitiator, an anionic component and water to obtain a precursor solution; (2) defoaming the precursor solution; (3) irradiating the precursor solution obtained in the step (2) with ultraviolet lightto initiate cationic monomer polymerization, and reacting the generated cationic monomer polymer with the anionic component to form the adhesive hydrogel; wherein in the step (1), the anionic component comprises glycosaminoglycan and derivatives thereof. The adhesive hydrogel disclosed by the invention is soft in texture, can be used for bonding various surfaces, is high in adhesion strength andhas self-healing performance, and the practicability of the gel is improved.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to an adhesive hydrogel and a preparation method thereof. Background technique [0002] In recent years, with the development of tissue engineering, biomedicine, wearable flexible devices and other fields, hydrogels have been shown in tissue adhesives and human-machine interfaces due to their advantages of softness and wetness, strong deformation ability and good biocompatibility. It has a good application prospect. [0003] The surface of traditional hydrogel is smooth, and there is no adhesion force between the surface of inorganic and organic substances. To apply hydrogel to the surface of human tissue or electronic devices, adhesives are needed to bond the hydrogel to the substrate. However, most of the traditional adhesives are toxic and not suitable for use in contact with the skin, and they are not elastic and cannot deform with the movement of the adherend, thus limiting th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L33/14C08L5/08C08F120/34
CPCC08F120/34C08J3/075C08J2305/08C08J2333/14
Inventor 陈莉邓泽鹏何洋江鹏王彦杰
Owner TIANJIN POLYTECHNIC UNIV
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