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A kind of cytarabine injection preparation and its preparation process

A technology of cytarabine and injection preparations, which is applied in the field of medicine and can solve problems such as the shortage of cytarabine injections

Active Publication Date: 2020-12-11
KINDOS PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problem of shortage of cytarabine injection, the present invention provides a cytarabine injection preparation, which can effectively prevent the safety risks in the injection process by adding an osmotic regulator and optimizing the preparation and development process of the preparation , and produce products whose product stability is better than that of the original research product

Method used

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  • A kind of cytarabine injection preparation and its preparation process

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Embodiment 1

[0027]A cytarabine injection preparation, by mass, comprises 10 parts of cytarabine, 5 parts of benzyl alcohol, 1 part of sodium chloride, 1 part of sodium bicarbonate and water for injection in a constant volume to 1000 parts.

Embodiment 2

[0029]A cytarabine injection preparation, by mass, comprises 30 parts of cytarabine, 10 parts of benzyl alcohol, 5 parts of sodium chloride, 5 parts of sodium bicarbonate, and water for injection in a constant volume to 1000 parts.

Embodiment 3

[0031]A cytarabine injection preparation, by mass, comprises 20 parts of cytarabine, 9 parts of benzyl alcohol, 2 parts of sodium chloride, 2 parts of sodium bicarbonate and water for injection in a constant volume to 1000 parts.

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Abstract

The invention discloses a cytarabine injection which comprises, by mass, 10 to 30 parts of cytarabine, 5 to 10 parts of benzyl alcohol, 1 to 5 parts of sodium chloride, 1 to 5 parts of sodium bicarbonate and water for injection, wherein the volume of the water for injection is metered to 1000 parts. By adding an osmotic adjusting agent and optimizing the preparation and development process of thepreparation, the safety risk existing in the injection process can be effectively prevented, and the stability of the produced product is superior to the stability of the product of the original research product.

Description

Technical field[0001]The invention relates to the technical field of medicine, in particular to a cytarabine injection preparation.Background technique[0002]Cytarabine is an ancient anti-cancer drug, and its earliest application began in 1969. It is also a versatile cancer treatment drug. For example, cytarabine combined with anthracycline antibiotics can treat acute myeloid leukemia and lymphoma. It is also very common in alternative treatments for other cancers. In particular, for certain specific chemotherapy regimens, the combination of chemotherapy drugs and cytarabine can achieve a cure rate of 40% to 50% for leukemia, but if no cytarabine is involved in the treatment, the cure rate is 0% . For these patients, the difference between using cytarabine is life and death.[0003]Leukemia currently ranks first in the incidence and mortality of childhood malignant tumors in my country. Cytarabine is mainly used for leukemia chemotherapy and transplantation pretreatment, especially in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/7068A61K47/02A61P35/00A61P35/02
CPCA61K9/0019A61K9/08A61K31/7068A61K47/02A61P35/00A61P35/02
Inventor 谢谦史宣宇田欣欣
Owner KINDOS PHARM CO LTD