Use of red semblance extract for improving the gene expression of hyaluronic acid synthase
A technology of gene expression and red sorghum, applied in the direction of drug combination, function of food ingredients, food ingredients containing natural extracts, etc. Reduces wrinkles and improves skin barrier function
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Embodiment 1
[0018] Embodiment 1 The preparation method of the red saffron extract of the present invention
[0019] Trifolium pratense (Trifolium pratense) is a perennial herbaceous plant of the genus Trifolium in the Fabaceae family. It is native to Europe and northern Asia. It was introduced into Taiwan in the early days as a forage grass and soil and water conservation plant, and it is also occasionally planted for ornamental purposes. The stem of the red samosa is an upright or oblique ascending stem, about 15-65 cm long, with branches and scattered hairs; the leaves are three compound leaves, ovate, obovate or oblong, about 1.5-3 cm long , 0.5-2 cm wide; the flowers are pink and densely grown, arranged in a flower head. Red Shucao has the effect of clearing away heat, relieving cough and reducing swelling.
[0020] In one embodiment of the present invention, the whole plant of Red Shucao is cleaned, and the washed whole plant of Red Shucao is mixed with an extraction solvent of wate...
Embodiment 2
[0021] Example 2 Efficacy of the red saffron extract of the present invention in regulating gene expression in keratinocytes
[0022] The present invention uses human primary epidermal keratinocytes (HPEK) to regulate TGM1 gene, KRT1 gene, KRT10 gene, KRT14 gene, APQ3 gene, FLG gene, SMAD1 gene, GBA gene, Analysis of HAS2 gene and HAS3 gene expression. The human primary skin keratinocytes were purchased from CELLnTEC (Switzerland) No. HPEK-50, and the cells were cultured in serum-free keratinocyte medium (keratinocyte-SFM) (Gibco, No. #17005042, U.S.), and contained 5%CO 2 cultured in a 37°C cell culture incubator.
[0023] Human primary keratinocytes were divided into two groups: (1) the experimental group adding 0.0039 mg / mL of the red sage extract of the present invention and (2) the control group containing only the cell culture medium for 24 hours, and then the keratinocytes were After the cells were recovered with cell lysate (RBbuffer, purchased from Geanaid Company,...
Embodiment 3
[0028] Example 3 The effect of the red saffron extract of the present invention on increasing the water content of human skin and reducing wrinkles
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